Syncope, familial vasovagal

This study compares a new technique called total underwater colonoscopy (using water instead of gas) to the standard method in over 1,000 people undergoing screening after a positive stool test. The goal is to see if water helps doctors find more flat, hard-to-spot polyps that ca…

This study is testing a pacemaker lead placed in a specific area of the heart called the left bundle branch area. The goal is to see if this placement is safe and helps the heart beat more naturally in people with slow heart rates. About 140 participants will get the lead and be …

This study tests two ways to treat a slow heart rate caused by overactive nerves, without using a permanent pacemaker. One method uses freezing (cryoablation) and the other uses burning (radiofrequency) to calm the nerves. Sixty adults aged 18 to 60 with symptoms like fainting or…

This study tests whether using a portable heart monitor for 15 days after a fainting episode can detect dangerous heart rhythms that standard short-term monitoring might miss. About 580 adults who fainted and are at medium or high risk will be randomly assigned to either usual ca…

This study looks at how a procedure called cardioneuroablation (CNA) affects exercise performance in people who faint due to a sudden slow heart rate. CNA stops certain nerves from slowing the heart too much, but it might also make the heart beat faster during exercise. Researche…

This study is tracking 300 people under age 60 who faint frequently due to a condition called vasovagal syncope. Participants will receive either a nerve ablation procedure (which targets heart nerves) or a permanent pacemaker. The goal is to see which treatment better prevents f…

This study tests an artificial intelligence program that analyzes heart rhythm data from a small, wearable patch to estimate how well the heart pumps blood. Researchers will compare the AI's results to standard ultrasound in 2,000 adults. If accurate, this could offer a simpler, …

This study looks at whether a tilt table test, which provokes fainting in a controlled setting, can help people with vasovagal syncope (common fainting) reduce future episodes. About 238 adults will be randomly assigned to receive biofeedback training either with or without the t…

This study looks at whether carbonated water can help people stay steady on their feet and avoid fainting. Drinking water is known to raise blood pressure, but researchers want to see if the bubbles in carbonated water add an extra benefit by stretching the stomach. 25 healthy ad…

This study tests whether simple physical maneuvers like leg crossing, bending, or arm tensing can prevent fainting in children aged 6 to 18. Participants who visit the emergency department after a fainting episode will either receive standard care or learn these counterpressure m…

This study tests whether a wearable Holter monitor can detect early signs of fainting in people with orthostatic hypotension or reflex syncope. Forty adults who have already had a tilt-table test will wear the monitor for up to 21 days. The goal is to see if the device can pick u…

This study looks at how different heart rates and body positions change the amount of blood the heart pumps. Researchers will safely adjust the heart rates of 25 people with permanent pacemakers while they lie down or stand up. The goal is to better understand fainting spells (va…

This study looks at whether simple leg movements, like crossing legs or tensing buttock muscles, can raise blood pressure in children aged 6-18 who faint often. Researchers will measure heart and blood flow responses during these movements in 30 children. The goal is to understan…

This study looks at whether keeping low- and intermediate-risk fainting patients in the hospital for 24 hours with a heart monitor is better than sending them home right away. About 640 adults will be randomly assigned to either stay or go home. The goal is to see if the longer m…

This study looks at whether certain medications known to affect the heart's electrical activity (QT-prolonging drugs) actually cause major heart problems in hospitalized adults. Researchers will analyze data from over 990,000 patients across Ontario hospitals, comparing those who…

This study watches how well a small heart monitor (BIOMONITOR III) works in routine medical care for 1400 people. It tracks how quickly the device finds hidden heart rhythm problems like atrial fibrillation or fainting spells. The goal is to learn about the device's real-life per…

This study is a registry that collects information from 1,000 adults who have conditions like fainting, rapid heartbeat, or low blood pressure and have received a procedure that adjusts nerve signals to the heart. Researchers will track whether symptoms return within a year. The …

This study looks at a new procedure called cardioneuroablation for people with severe fainting spells. The procedure uses radio waves to target specific nerve clusters in the heart. The study will compare three methods to find these nerve clusters: electrical signals, CT scans, a…

This study from Mayo Clinic looks for genetic heart conditions in people with epilepsy that might raise the risk of sudden unexpected death (SUDEP). Researchers will analyze DNA from 600 adults aged 18-50 with epilepsy or related symptoms, plus their blood relatives. The goal is …