Sweat gland disorder

This phase 2 trial tests whether injecting botulinum toxin (Botox) into skin affected by hidradenitis suppurativa (HS) can reduce the number of painful abscesses, nodules, and draining tunnels, and ease pain. About 40 people with HS will receive either Botox or a saline placebo i…

Researchers are testing different doses of duvakitug, an injected drug, against placebo in adults with moderate to severe hidradenitis suppurativa. The trial enrolls about 156 people who have painful lumps and tunnels in at least two skin areas. Participants receive either duvaki…

This phase 2 trial tests whether an investigational medicine called SPY072 can improve hidradenitis suppurativa (HS), a chronic skin condition causing painful lumps and tunnels. About 150 adults with moderate-to-severe HS who are already receiving standard care will be randomly a…

This study tests a medicated foam called roflumilast applied daily to hidradenitis suppurativa (HS) lesions for 16 weeks. It includes adolescents and adults with mild to moderate HS (Hurley stage I or II) who have 4 to 10 painful lumps or abscesses but no draining tunnels. The ma…

This study looks at whether starting secukinumab early in people with moderate-to-severe hidradenitis suppurativa (a chronic skin condition causing painful lumps) can slow disease progression. Researchers will analyze data from existing medical records and registries across Europ…

This pilot study tests whether fecal microbiota transplantation (FMT) can improve moderate to severe hidradenitis suppurativa (HS), a painful skin condition. Researchers will give 24 adults a single FMT and track changes in their skin lesions over 12 weeks. The goal is to see if …

This study tests whether combining an anti-IL-17A/F antibody (bimekizumab) with a non-ablative fractional laser can safely reduce symptoms of mild to moderate hidradenitis suppurativa, a chronic skin condition causing painful lumps. Fifty adults will receive the combination every…

This study will test whether applying a special heat-reflecting coating to roofs can improve the health and well-being of 800 households in Colima, Mexico. The coating is designed to keep homes cooler indoors, which may help lower heart rate, improve blood sugar control, reduce d…

This Phase II trial tests QLS12010, an oral capsule, in 102 adults with moderate-to-severe hidradenitis suppurativa (HS), a painful skin condition. The study has two parts: an open-label proof-of-concept phase and a placebo-controlled dose-ranging phase. Participants must have tr…

This study compares injecting secukinumab directly into skin lesions versus standard under-the-skin injections for people with localized hidradenitis suppurativa (HS). The goal is to see if local delivery works better and causes fewer side effects. Thirty adults with HS lesions i…

Researchers are testing a new way to measure how much sweat the body produces during controlled heat exposure. About 20 healthy volunteers and up to 10 people with ROSAH syndrome, a rare genetic condition that can cause reduced sweating, will sit in a temperature-controlled sauna…

Researchers are testing an experimental oral drug called soquelitinib in adults with moderate-to-severe hidradenitis suppurativa, a chronic skin condition that causes painful lumps and tunnels. The trial aims to see if the drug is safe and can reduce the number of inflammatory le…

This pilot study tests whether a 16-week Mediterranean-style diet program is practical and acceptable for adults with hidradenitis suppurativa, a chronic skin condition. All 30 participants receive the same program, which includes video counseling, cooking education, and food sup…

This study tests whether alexandrite laser works as well as Nd:YAG laser for treating hidradenitis suppurativa (HS), a painful skin condition. Twenty-one people will receive both lasers on different sides of their body to compare results. The goal is to see if alexandrite can red…

This observational study aims to collect and analyze data from up to two million patients with dermatologic conditions like vitiligo, atopic dermatitis, alopecia areata, and hidradenitis suppurativa, as well as their healthcare providers. By reviewing treatment patterns, outcomes…

This study builds a long-term research cohort for people with psoriasis, eczema, or hidradenitis suppurativa. Participants use a certified app to answer symptom questions and take standardized photos of their skin once a month, with longer questionnaires twice a year. Trained ass…

This registry study collects real-world data from about 300 adults treated with urinary bladder matrix (UBM) products for various wounds, including pressure ulcers, surgical incisions, and infections like Fournier's gangrene. Researchers track patient characteristics, treatment p…

This study follows 34 adults with moderate-to-severe hidradenitis suppurativa (HS) who are taking secukinumab as part of their routine care. Researchers will use a special CT scan to check if the drug affects the buildup of plaque in the heart arteries over 12 months. The goal is…

This study follows 5,000 people with common inflammatory skin conditions—like eczema, psoriasis, and hidradenitis suppurativa—over up to 17 years to see how their disease severity changes. Researchers will collect medical history, treatments, and symptom scores to identify factor…

This study aims to create a reliable, long-lasting itch model by combining heat with substances that cause itching, like histamine and cowhage. Researchers will measure how 28 healthy adults rate their itch and pain sensations, along with skin blood flow. The goal is to better un…

This study looks at how certain immune cells, called MAIT cells, behave in people with hidradenitis suppurativa (HS), a painful skin condition. Researchers will take skin and blood samples from 45 adults with HS and compare them to samples from people with other skin diseases. Th…

This study will collect existing medical records from about 20,000 people aged 12 and older in Italy who have one of five inflammatory skin conditions: psoriasis, atopic dermatitis, vitiligo, alopecia areata, or hidradenitis suppurativa. Researchers want to describe who gets thes…

This study looks at how sex hormones, especially during pregnancy, change the immune cells in the skin. Researchers will compare pregnant women, non-pregnant women, and men, both with and without a skin condition called hidradenitis suppurativa. The goal is to understand how horm…

This study will follow 100 Canadian adults with hidradenitis suppurativa (HS), a painful skin condition, to measure how it affects their work and daily life. Participants will fill out questionnaires about work productivity and quality of life. No treatment is given—the goal is t…