Stenosis or atrophy of the coronary ostium

Researchers are studying how heart arteries change after a blocked vessel is opened with a paclitaxel drug-coated balloon instead of a metal stent. The balloon delivers a drug to the artery wall and then is removed, leaving no permanent implant. About 150 adults who had this proc…

This pilot study tests whether putting back a child's own thymus tissue during heart surgery is safe and helps support the immune system. In some congenital heart disease surgeries, the thymus is removed to reach the heart, which may weaken immunity. Researchers will compare chil…

This trial tests whether adding a blood-filtering device, called hemoadsorption, to the heart-lung machine can reduce harmful inflammation in children undergoing complex open-heart surgery. The device is designed to remove inflammatory proteins, known as cytokines, from the blood…

This trial tests a new device called the Angimis Atherectomy System, which uses laser energy to break up plaque in coronary arteries that are too narrow or hardened for standard balloon or stent procedures. The study enrolls adults with coronary artery disease who have at least o…

This trial tests whether a personalized exercise program before heart surgery can improve physical fitness in adults with congenital heart disease. Participants are randomly assigned to either usual care or a 6-week prehabilitation plan with aerobic, breathing, and strength exerc…

This study looks at whether older adults (65+) who get a heart stent can safely stop one of their blood thinners (aspirin) after just 7 days instead of the usual 3 to 12 months. The goal is to see if this shorter treatment reduces bleeding risks without increasing heart attacks, …

Researchers at Assiut University Hospitals are studying how well fetal heart scans before birth match the heart diagnoses babies receive after delivery. The study includes pregnant women referred for fetal echocardiography and newborns with confirmed critical congenital heart dis…

This study enrolls children and young adults scheduled for heart surgery or catheterization under general anesthesia. Researchers place a forehead sensor that measures tissue oxygen levels and use an algorithm to estimate blood hemoglobin. The goal is to see if this noninvasive m…

This study explores whether a newer type of SPECT/CT scan can accurately measure blood flow in the heart, similar to the more expensive and less available PET scan. Researchers will compare the two imaging methods in 30 adults with coronary artery disease who are already schedule…

This study tests whether an artificial intelligence system called AngioAI+ can accurately diagnose two types of coronary artery disease using standard angiogram images. The research involves 620 adults with suspected coronary artery disease who are already scheduled for an angiog…

This study will check how accurate chest X-rays are at finding congenital heart disease in newborns. Researchers will study 60 babies in the NICU who show signs of heart problems. Each baby gets a chest X-ray within 24 hours and an echocardiogram within 72 hours. By comparing the…

This trial tests whether cutting out a small fibrous structure called the Ligament of Marshall during minimally invasive heart bypass surgery can prevent new-onset atrial fibrillation (an irregular heartbeat) that often occurs after the operation. The study will include 628 adult…

This study will test two different surgical techniques used during heart bypass surgery to see which one better prevents a common complication called atrial fibrillation (irregular heartbeat). The trial will involve 122 adults having their first planned bypass surgery. Researcher…

Researchers are testing whether squeezing a stress ball during femoral arterial sheath removal after coronary angiography can reduce pain and anxiety and improve patient satisfaction. The trial enrolls 34 adults who had a stent or balloon angioplasty through the femoral artery. H…

This trial asks whether discharge education personalized by artificial intelligence can improve recovery after coronary artery bypass grafting. About 80 adults who have had elective bypass surgery will be randomly assigned to receive either standard discharge education or standar…

This trial tests whether a targeted nerve block, called an adductor canal block, can reduce leg pain after coronary artery bypass grafting (CABG) when a leg vein is used as a graft. About 120 adults scheduled for CABG will receive either the block with a numbing medication or a s…

This study tests whether injecting a long-acting numbing medicine (bupivacaine) through chest tubes can safely reduce pain and lower the need for strong painkillers after heart bypass surgery. Sixty adults will receive either the numbing medicine or a saltwater placebo whenever t…

This observational study tests whether a new device, the SpectroCor Tissue Oxygenation Monitor, can accurately track oxygen levels in the heart muscle of children undergoing open-heart surgery. The device uses a sensor placed on the heart to measure oxygen availability during key…

This study is a large, real-world registry that will include over 10,000 people with coronary artery disease from more than 50 hospitals across China. The goal is to see how often a software tool called QFR, which analyzes angiogram images to guide treatment decisions, is used in…

This study tests a personalized, digitally supported prehabilitation program for adults waiting for elective cardiac surgery. Participants receive education, psychosocial support, nutritional advice, and home-based exercise guidance during the routine 6-10 week preoperative perio…

This study will follow 600 adults having off-pump heart bypass surgery to see how often memory and thinking problems occur afterward. Participants take a simple thinking test before and after surgery. The goal is to understand what factors might increase the risk of these problem…

This study tests two different computer alerts designed to encourage doctors to refer heart patients to cardiac rehab. About 7,000 adults who had heart surgery or a stent in the past year will take part. The goal is to see if these simple reminders increase the number of people w…

This study will follow 1000 adults in China with severe coronary artery disease who are too high-risk for bypass surgery and need complex angioplasty. Researchers will collect data on their health, procedures, and outcomes for one year to see what factors affect survival and comp…

This study will follow 1,800 people who had a stent placed in their heart arteries using a special camera (OCT). Researchers want to see if new measurements from routine angiograms can better predict future heart problems like heart attacks or chest pain. The goal is to improve h…

This study will follow 600 people who need either bypass surgery (CABG) or a stent (PCI) to open blocked heart arteries. Researchers will test memory and thinking skills before the procedure and again at 1 month, 1 year, and 2 years after. The goal is to see if one approach leads…

This study looks at whether a special MRI scan can predict if patients will develop an irregular heartbeat (atrial fibrillation) after heart bypass surgery. About 100 adults scheduled for bypass will get an MRI before surgery and wear a heart monitor for a year. The goal is to fi…

This study looks at ways to help surgeons use more artery grafts instead of vein grafts during heart bypass surgery, since artery grafts last longer. It will involve about 8,700 patients across many hospitals. The study does not test a new drug or device, but rather tests trainin…

This study will test a handheld device called IntraOx that uses light to measure oxygen levels in heart and liver tissue during complex heart surgery in children. The goal is to see if it can give surgeons useful information about blood flow without interfering with the operation…

This study will compare three different fluids used to protect the heart during coronary artery bypass surgery. Researchers will measure tiny particles and immune system markers in the blood to see which fluid causes the least heart muscle injury. The goal is to find the safest a…

This study looks at how the antibiotic cefazolin spreads in the chest tissue of 10 children after heart surgery for congenital heart disease. A small probe placed during surgery will measure drug levels over 36 hours. The goal is to create a computer model to help doctors give th…

This study will create a national registry to collect data on 3,000 adults undergoing coronary artery bypass graft (CABG) surgery in Saudi Arabia. The goal is to track complications, recovery, and quality of life for one year after surgery. This information will help hospitals im…

This study will test a new, non-invasive ultrasound technique that captures brain blood flow in real time for infants with congenital heart disease. Researchers aim to understand how medical treatments and surgeries affect the brain, potentially explaining why some children later…