Status asthmaticus

This study tests whether arranging a telehealth appointment with an asthma specialist before patients leave the emergency room increases follow-up care. Forty adults who come to the ER for an asthma attack will either get a scheduled telehealth visit or usual care. The goal is to…

This study tests a nasal spray called RIG-101 in healthy people and those with asthma. First, it checks safety and tolerability. Then, asthma participants receive the spray daily and are exposed to a cold virus to see if it prevents asthma worsening. The trial is recruiting 82 ad…

This study compares three ways to give inhaled asthma medication to adults having a moderate-to-severe asthma attack in the emergency department. One group receives the standard nebulizer treatment, another uses a vibrating mesh nebulizer, and a third uses the vibrating mesh nebu…

This study tests whether giving adults with acute asthma a specific rescue inhaler (Airsupra) right in the emergency department can reduce the chance of another asthma attack within 3 months. About 1,860 participants will either receive Airsupra or continue usual care. The goal i…

This study tests whether using a blood test that measures eosinophil levels can help doctors tailor asthma treatments more effectively than standard care. About 240 adults with mild to moderate asthma will be followed for one year. The goal is to see if this approach reduces asth…

This study tests a procedure called bronchial thermoplasty (BT) for adults with severe asthma that remains uncontrolled even with biologic drugs. BT uses a thin tube to deliver heat to the airway walls, aiming to reduce muscle overreactivity. Researchers will compare asthma attac…

This study tests two ways to prevent asthma attacks: using inhaled steroids as a rescue inhaler (R-ICS) or taking azithromycin regularly. Researchers want to see which works better, alone or together, for people with poorly controlled asthma. About 3,200 people aged 13-75 with as…

This study tests a new device that uses artificial intelligence to help diagnose ear infections, strep throat, and asthma flare-ups in children. About 84 kids aged 3 to 17 will either use the device at home with a doctor's video visit or receive standard in-person care. The goal …

This study tests whether giving children aged 5-17 with severe asthma attacks early breathing support (called BPAP) in the emergency room is practical and safe. About 36 children will either get standard asthma care alone or standard care plus BPAP. The goal is to see if this app…

This study compares two common steroids (dexamethasone and methylprednisolone) in children aged 3-17 hospitalized for severe asthma. The goal is to see which treatment reduces the need for more steroids after leaving the hospital and improves quality of life. The trial will help …

This study tests whether adding hand acupuncture to standard medicine can quickly improve breathing during an asthma flare-up. Researchers will measure lung function and symptom scores in 72 adults over 5 days. The goal is to see if acupuncture offers a new, drug-free option for …

This study compares two different doses of the steroid dexamethasone (0.3 mg/kg vs. 0.6 mg/kg) given by mouth to children aged 4-15 who come to the emergency department with an asthma attack. The goal is to see which dose works better at reducing the need for another steroid pres…

This study tests whether giving children with asthma and their families Air Quality Index (AQI) information helps improve asthma control. 351 children will receive either EPA or commercial AQI education plus an asthma action plan, or standard care. Over 48 weeks, researchers will…

This study looks at whether a new way of organizing hospital care, called an Acute Medical Unit, can help older adults with sudden illnesses like infections or COPD get better faster and spend fewer days in the hospital. Researchers will compare 220 patients who receive this new …

This observational study enrolls 500 children aged 6-17 who come to the emergency department with an acute asthma attack. Researchers will check if doctors follow the latest GINA 2025 guidelines for diagnosis, treatment, and follow-up. The goal is to see if standardizing care imp…