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Asthma attack study seeks best steroid dose for kids

NCT ID NCT07402707

Symptom relief Sponsor: Sheffield Children's NHS Foundation Trust Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study compares two different doses of the steroid dexamethasone (0.3 mg/kg vs. 0.6 mg/kg) given by mouth to children aged 4-15 who come to the emergency department with an asthma attack. The goal is to see which dose works better at reducing the need for another steroid prescription within two weeks. The study will also track how often children need to return to the ER or see a doctor, and how well parents and kids tolerate the treatment. It is a small pilot study designed to gather information for a larger, more definitive trial.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
dexamethasone
What this could lead to
If successful, this could help determine the most effective dose of dexamethasone for children with asthma attacks, potentially reducing repeat steroid prescriptions and ER visits.
What could go wrong
This is a small pilot study (104 children) focused on feasibility, not definitive results. The two doses may show no clear difference, and a larger trial is needed to confirm any findings.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

About 104 people

The number the study aims to enrol. It can still change while the study runs.

Started

Feb 2026

Expected to finish

Aug 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

4 to 15 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Children aged 4-15 years (inclusive) presenting to the ED with an asthma exacerbation, where oral steroids are recommended by Trust/National guidelines. * Children whose parents/carers do not speak English will also be eligible provided they speak one of the common languages where an interpreter and Information Sheets are available (Slovakian, Arabic and Urdu). Exclusion Criteria: * Children who have been treated with oral or IV steroids in the last 2 weeks. * Hypersensitivity to the study drug. * Children who have concomitant stridor. * First episode of wheezing (not previously diagnosed as asthma). * Children with known difficult asthma who receive longer courses of steroids as standard. * Life threatening episode of asthma. * Children with other conditions that require them to have steroids when unwell. * Children who are involved in current research or have recently been involved in research prior to recruitment

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Conditions

The condition(s) this trial relates to.

acute asthma status asthmaticus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Acute asthma Dexamethasone

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Sheffield Children's NHS Foundation Trust

    RECRUITING

    Sheffield, S10 2TH, United Kingdom

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