Sleep-wake disorder

This study tests whether a 12-week program of supervised exercise, Mediterranean diet education, and stress management workshops can improve health in 120 overweight or obese adults. Participants will wear a smart bracelet to track activity and sleep. Researchers will measure cha…

This study compares a new software, C. Santé, to the standard sleep test (polysomnography) to see if it can accurately measure sleep quality. The software uses sensors on a bed to track breathing and heart rate without disturbing sleep. If successful, it could allow people to mon…

This study will develop and test artificial intelligence (AI) to automatically classify sleep stages from overnight sleep recordings (polysomnography). The goal is to see if the AI can match or beat expert manual scoring, with the aim of supporting diagnosis of chronic insomnia a…

Researchers are testing whether a monthly injection of berobenatide can reduce the severity of obstructive sleep apnea and lower body weight in adults who have overweight or obesity and use a PAP breathing machine. The trial enrolls about 258 adults with moderate to severe sleep …

Researchers are testing whether a structured breathing program called Active Cycle of Breathing Techniques, combined with a handheld positive expiratory pressure device, can improve breathing, sleep, and mood in people with COPD. The trial enrolls 60 adults aged 40 to 90 with dia…

This study looks at two ways to improve sleep after breast cancer surgery: a nerve block injection or a mild ear stimulation device. About 136 women will be randomly assigned to one of the two treatments. Their sleep will be tracked with a wrist monitor and questionnaires for the…

This study looks at whether racism-related stress affects how well a digital cognitive behavioral therapy program (Sleepio) works for insomnia in Black adults. One hundred participants will use the app for 6-10 weeks while researchers track their sleep and stress levels. The goal…

This trial tests whether low-frequency repetitive transcranial magnetic stimulation (rTMS) can improve sleep quality in adults undergoing surgery for lung cancer. Participants with poor sleep before surgery will receive either active rTMS or a sham (inactive) treatment over five …

This trial tests whether low-frequency repetitive transcranial magnetic stimulation (rTMS) can improve sleep quality in adults recovering from a lung transplant. Participants with sleep problems during their hospital stay will receive either active rTMS or a sham (inactive) treat…

This trial tests whether low-frequency repetitive transcranial magnetic stimulation (rTMS) can improve sleep quality in adults with advanced non-small cell lung cancer who have trouble sleeping during hospital stays. Researchers will randomly assign 160 participants to receive ei…

This trial tests whether coloring mandalas—intricate circular patterns—can help reduce anxiety and improve sleep quality in female students who experience premenstrual syndrome (PMS). Participants will be asked to color mandalas, and researchers will measure changes in their anxi…

This trial tests whether connective tissue massage, given three times a week for four weeks, can reduce insomnia severity in adults with chronic insomnia. Participants also receive sleep hygiene education, and the control group gets education alone. The study measures sleep quali…

This study tests whether AI-based cognitive training, using the Lumosity app, combined with a tailored physical-therapy program can improve sleep and quality of life in people with multiple sclerosis. Participants aged 25-40 with mild to moderate disability will undergo the train…

This study tests a program to help adult patients sleep better in the intensive care unit (ICU) after surgery. The program includes sleep education, earplugs and eye masks, reducing noise and light at night, and grouping nursing tasks to avoid waking patients. Researchers will co…

This study tests a special device that monitors sleep without any physical contact, designed for people with Alzheimer's or related dementias living in long-term care facilities. About 100 residents will use the device for four weeks. Researchers want to see if sharing sleep data…

This study tests whether learning progressive muscle relaxation and deep breathing exercises can improve sleep for cancer patients receiving chemotherapy. About 40 adults aged 40-60 with poor sleep will be split into two groups: one gets relaxation training plus usual care, the o…

This study tests whether a nasal spray containing two medicines, dexmedetomidine and esketamine, can improve sleep quality and thinking abilities in older adults with mild-to-moderate Alzheimer's-related cognitive impairment and sleep problems. Sixty participants will receive eit…

This study tests whether a drug called gamma-hydroxybutyrate (GHB) can help intensive care patients get better deep sleep. Sleep problems are very common in the ICU and can lead to serious issues like confusion and longer recovery. The trial will give GHB or a placebo to 24 adult…

This study tests whether taking steroids (dexamethasone) for a few days after sleep surgery helps reduce pain, allows patients to eat solid food sooner, and lowers the need for strong painkillers. About 120 adults with obstructive sleep apnea will receive either the steroid or a …

This study tests whether a special smartwatch can improve sleep in warfighters who have trouble sleeping due to PTSD, traumatic brain injury, or stress. The watch detects signs of stress during sleep, like a fast heart rate, and gives gentle vibrations to calm the body without wa…

This study tests whether a single session of sleep hygiene education can improve sleep quality and reduce pain in 100 adults with migraine or chronic lower back pain. Participants will learn healthy sleep habits and follow them for four weeks, tracking changes through questionnai…

This study tests whether an 8-week Mindfulness-Based Stress Reduction (MBSR) program can reduce hot flashes and improve sleep in menopausal women. 90 women aged 45-60 with hot flashes and poor sleep will be randomly assigned to either the MBSR program or no intervention. The prog…

This study tests a noninvasive device that stimulates a nerve in the leg to help people with restless legs syndrome who have developed complications from their usual medication. About 50 adults will use the device at home for 8 weeks. Researchers will measure changes in symptom s…

This study tests whether using a virtual reality headset for guided relaxation after night shifts can improve sleep quality in nurses and nursing assistants. Forty participants will either use the VR device for one month or receive standard care, then switch. Sleep quality, insom…

This study looks at whether teaching people with rotator cuff syndrome the best sleeping positions can improve their sleep quality while they undergo physical therapy. Researchers will compare two groups: one getting standard physical therapy, and another getting physical therapy…

This early study tests a neck device that uses gentle suction to keep the airway open during sleep, which might help people with obstructive sleep apnea. Ten healthy volunteers will wear the device during one night of sleep and compare their breathing to a night without it. The g…

This study tests whether increasing ward rounds from twice to four times a day, with structured conversations and simple breathing exercises, can lower anxiety in hospitalized patients waiting for therapeutic gastrointestinal endoscopy. About 1,000 adults with mild anxiety will t…

This study tests whether a mobile app called SleepQ can reduce insomnia symptoms in adults. The app provides a 12-week digital cognitive behavioral therapy program, including sleep scheduling and relaxation techniques. Eighty participants will be randomly assigned to use the app …

This study looks at whether eating special healthy cookies high in linoleic acid (a type of fat) for 8 weeks can improve sleep quality in overweight adults who have trouble sleeping. Researchers will measure sleep changes, blood fat levels, and how well people stick to eating the…

This study evaluates whether several sleepiness questionnaires are reliable for children and adolescents aged 6 to 17. It includes three groups: children from the general population, those with sleep disorders or conditions like narcolepsy or ADHD, and healthy volunteers. The goa…

This study looks at whether taking melatonin earlier in the evening (3 hours before bed) or at a higher dose (4 mg) helps healthy adults fall asleep faster and sleep better. Fourteen participants will try different combinations of melatonin and placebo while their sleep is measur…

This study looks at how physical activity levels are linked to posture, sleep quality, depression, and muscle or joint pain in health science professors and researchers at Istanbul Aydin University. About 73 academics aged 23 to 65 will fill out questionnaires. The goal is to und…

This study follows 160 adults in Hong Kong over time to see if disruptions in daily activity and sleep (rest-activity rhythms) can predict who develops major depressive disorder. Participants will wear activity monitors and complete questionnaires about mood and sleep. The goal i…

This study will check for stress, anxiety, depression, sleep problems, and bad breath in 110 adults with obesity who are getting ready for weight-loss surgery. Participants will fill out questionnaires and use a portable breath tester. The goal is to learn more about these issues…