Severe cutaneous adverse reaction

This trial is testing a lab-grown skin substitute called denovoSkin in children with deep burns. The engineered skin is made from the child's own cells and is compared to the standard treatment of using a split-thickness skin graft. The goal is to see if denovoSkin can cover burn…

This study compares two treatments—nanofat injections and fractional CO2 laser—used alone or together for post-traumatic atrophic scars (depressed scars from injury). Sixty participants receive one of the three approaches. The goal is to see if combining both treatments improves …

This study tests whether adding a special gauze dressing (called a tie-over bolster) on top of regular stitches can reduce scarring after surgery on the head or neck. Sixty adults will have their wound closed normally, then half the wound gets the extra bolster. Doctors and patie…

This study tests whether combining two types of laser treatments—pulsed dye laser (PDL) and fractional photothermolysis—can improve how surgical scars look. Adults who had a dermatologic surgery on their trunk or limbs can join. Some participants receive the laser combination at …

This study compares two devices—ePrime (radiofrequency) and Fraxel (laser)—to see which improves acne scars more. Each participant gets both treatments on different sides of their face, and a blinded dermatologist rates the results. The goal is to find a more effective way to red…

This study looks at whether applying a silicone ointment to the skin before head and neck surgery helps wounds heal with less scarring. About 60 adults having non-emergency surgery will take part. Researchers will compare scars using standard rating scales and also track hospital…

This study looks at a way to possibly reduce scarring after surgery on the neck, trunk, arms, or legs. The technique, called "undermining," involves loosening the skin near the wound tips to reduce tension. Half of each wound will get this extra step, and the other half will not,…

This study tests whether injecting botulinum toxin (Botox) into biopsy wounds can reduce scarring compared to a placebo. Twelve healthy adults will each receive both treatments on different spots on their back, and scars will be compared over six months. The goal is to see if Bot…

This study planned to test a fractional ablative erbium laser on scarring caused by hidradenitis suppurativa (HS) in the armpit area. It was designed for adults with mild HS activity and visible scars. However, the trial was withdrawn before enrolling any participants, so no resu…

This study looks at whether using sunscreen on a healing surgical scar improves how it looks. Fifty adults who had skin cancer surgery will have half of their scar treated with sunscreen and the other half left alone. After three months, doctors will compare the two sides to see …

This study looks at how skin elasticity differs by age and skin type, both on normal facial skin and on surgical scars. Researchers will compare people who have had a skin resurfacing or tightening procedure with those who have not. The goal is to create baseline elasticity score…

This study aimed to compare a less invasive procedure called vacuum-assisted excision (VAPE) to standard surgery for removing non-cancerous but high-risk breast lesions. The goal was to see if VAPE worked as well, was safer, and left better cosmetic results. However, the study wa…