Retinal degeneration
MONDO:0004580Degeneration of the retina.
Also known as: retina degeneration, retina, Degeneration Of
582 clinical trials for this condition and its sub-types, 41 tagged with Retinal degeneration itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
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Sub-types of Retinal degeneration
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Inherited retinal dystrophy 41 trials · 510 incl. sub-types
105 sub-types
- Age-related macular degeneration 190 trials · 334 incl. sub-types Sub-types →
- Retinitis pigmentosa 84 trials · 89 incl. sub-types Sub-types →
- Hereditary macular dystrophy 3 trials · 70 incl. sub-types Sub-types →
- Cone-rod dystrophy 17 trials · 21 incl. sub-types Sub-types →
- Leber congenital amaurosis 10 trials · 12 incl. sub-types Sub-types →
- ABCA4-related retinopathy 7 trials · 11 incl. sub-types Sub-types →
- BEST1-related dominant retinopathy 1 trial · 7 incl. sub-types Sub-types →
- RHO-related retinopathy 0 trials · 7 incl. sub-types Sub-types →
- RPE65-related recessive retinopathy 5 trials · 7 incl. sub-types Sub-types →
- RPGR-related retinopathy 0 trials · 7 incl. sub-types Sub-types →
- Choroideremia 6 trials Sub-types →
- PRPF31-related retinopathy 1 trial · 4 incl. sub-types Sub-types →
- X-linked retinoschisis 4 trials
- Ornithine aminotransferase deficiency 4 trials
- ELOVL4-related maculopathy 0 trials · 3 incl. sub-types Sub-types →
- RLBP1-related retinopathy 2 trials · 3 incl. sub-types Sub-types →
- Retinal vasculopathy with cerebral leukoencephalopathy and systemic manifestations 3 trials
- BEST1-related recessive retinopathy 0 trials · 2 incl. sub-types Sub-types →
- EYS-related retinopathy 1 trial · 2 incl. sub-types Sub-types →
- LCA5-related retinopathy 1 trial · 2 incl. sub-types Sub-types →
- PRPH2-related retinopathy 1 trial · 2 incl. sub-types Sub-types →
- Revesz syndrome 2 trials
- Late-onset retinal degeneration 2 trials
- AIPL1-related retinopathy 1 trial Sub-types →
- ATF6-related retinopathy 0 trials · 1 incl. sub-types Sub-types →
- CNGB1-related retinopathy 0 trials · 1 incl. sub-types Sub-types →
- FLVCR1-related retinopathy with or without ataxia 0 trials · 1 incl. sub-types Sub-types →
- GUCY2D retinopathy 0 trials · 1 incl. sub-types Sub-types →
- RDH5-related retinopathy 0 trials · 1 incl. sub-types Sub-types →
- Retinoschisis of fovea 1 trial
- ADAM9-related retinopathy 0 trials Sub-types →
- CACNA1F-related retinopathy 0 trials Sub-types →
- CACNA2D4-related retinopathy 0 trials Sub-types →
- CDHR1-related retinopathy 0 trials Sub-types →
- CERKL-related retinopathy 0 trials Sub-types →
- CNGA1-related retinopathy 0 trials Sub-types →
- CNGA3-related retinopathy 0 trials Sub-types →
- CRX-related retinopathy 0 trials Sub-types →
- GNAT2-related retinopathy 0 trials Sub-types →
- GPR179-related retinopathy 0 trials Sub-types →
- GRM6-related retinopathy 0 trials Sub-types →
- GUCA1A-related retinopathy 0 trials Sub-types →
- HGSNAT-related retinopathy 0 trials Sub-types →
- IDH3B-related retinopathy 0 trials Sub-types →
- IMPDH1-related retinopathy 0 trials Sub-types →
- IMPG1-related dominant retinopathy 0 trials Sub-types →
- IMPG1-related recessive retinopathy 0 trials Sub-types →
- IMPG2-related dominant retinopathy 0 trials Sub-types →
- IMPG2-related recessive retinopathy 0 trials Sub-types →
- KCNV2-related retinopathy 0 trials Sub-types →
- KIZ-related retinopathy 0 trials Sub-types →
- LRIT3-related retinopathy 0 trials Sub-types →
- MAK-related retinopathy 0 trials Sub-types →
- MERTK-related retinopathy 0 trials Sub-types →
- MRCS syndrome 0 trials
- NMNAT1-related retinopathy 0 trials Sub-types →
- NYX-related retinopathy 0 trials Sub-types →
- Oguchi disease 0 trials Sub-types →
- PCARE-related retinopathy 0 trials Sub-types →
- PDE6A-related retinopathy 0 trials Sub-types →
- PDE6C-related retinopathy 0 trials Sub-types →
- PDE6G-related retinopathy 0 trials Sub-types →
- PROM1-related retinopathy 0 trials Sub-types →
- PRPF8-related retinopathy 0 trials Sub-types →
- RAB28-related retinopathy 0 trials Sub-types →
- RD3-related retinopathy 0 trials Sub-types →
- RDH12-related dominant retinopathy 0 trials
- RDH12-related recessive retinopathy 0 trials Sub-types →
- REEP6-related retinopathy 0 trials Sub-types →
- RP1-related dominant retinopathy 0 trials
- RP1-related recessive retinopathy 0 trials
- RP2-related retinopathy 0 trials Sub-types →
- RPE65-related dominant retinopathy 0 trials Sub-types →
- SNRNP200-related dominant retinopathy 0 trials Sub-types →
- SPATA7-related retinopathy 0 trials Sub-types →
- Sorsby fundus dystrophy 0 trials Sub-types →
- TOPORS-related retinopathy 0 trials Sub-types →
- TRPM1-related retinopathy 0 trials Sub-types →
- TTLL5-related retinopathy 0 trials Sub-types →
- X-linked intellectual disability-limb spasticity-retinal dystrophy-diabetes insipidus syndrome 0 trials
- X-linked retinal dysplasia 0 trials
- Aceruloplasminemia 0 trials
- Amaurosis-hypertrichosis syndrome 0 trials
- Choroideremia-deafness-obesity syndrome 0 trials
- Dystrophies primarily involving the retinal pigment epithelium 0 trials
- Ectopia lentis-chorioretinal dystrophy-myopia syndrome 0 trials
- Familial benign flecked retina 0 trials
- Foveal hypoplasia-presenile cataract syndrome 0 trials
- Helicoid peripapillary chorioretinal degeneration 0 trials
- Infantile cerebellar-retinal degeneration 0 trials
- Macular degeneration, early-onset 0 trials
- Microcephaly and chorioretinopathy 1 0 trials
- Microcephaly with or without chorioretinopathy, lymphedema, or intellectual disability 0 trials
- Microcornea-myopic chorioretinal atrophy 0 trials
- Oligocone trichromacy 0 trials
- Pigmented paravenous retinochoroidal atrophy 0 trials
- Progressive bifocal chorioretinal atrophy 0 trials
- Progressive retinal dystrophy due to retinol transport defect 0 trials
- Retinal degeneration-nanophthalmos-glaucoma syndrome 0 trials
- Retinal dystrophies primarily involving Bruch's membrane 0 trials Sub-types →
- Retinal dystrophy in systemic or cerebroretinal lipidoses 0 trials
- Retinal dystrophy with inner retinal dysfunction and ganglion cell anomalies 0 trials
- Retinal dystrophy, X-linked, Gardner-Hardcastle type 0 trials
- Retinoschisis, autosomal dominant 0 trials
- Vitreoretinal dystrophy 0 trials
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Macular degeneration 212 trials · 426 incl. sub-types
9 sub-types
- Degeneration of macula and posterior pole 0 trials · 354 incl. sub-types Sub-types →
- Stargardt disease 33 trials · 34 incl. sub-types Sub-types →
- Macular retinal edema 19 trials · 27 incl. sub-types Sub-types →
- Vitelliform macular dystrophy 6 trials · 10 incl. sub-types Sub-types →
- Autosomal recessive bestrophinopathy 2 trials
- Isolated macular dystrophy 0 trials
- Macular degeneration, early-onset 0 trials
- Occult macular dystrophy 0 trials
- Patterned macular dystrophy 0 trials Sub-types →
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Retinoschisis 5 trials · 6 incl. sub-types
5 sub-types
- X-linked retinoschisis 4 trials
- Retinoschisis of fovea 1 trial
- Bullous retinoschisis 0 trials
- Flat retinoschisis 0 trials
- Retinoschisis, autosomal dominant 0 trials
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Peripheral retinal degeneration 1 trial · 2 incl. sub-types
6 sub-types
- Retinal lattice degeneration 1 trial
- Blessig's cysts 0 trials
- Cobblestone retinal degeneration 0 trials
- Pseudoretinitis pigmentosa 0 trials
- Secondary vitreoretinal degeneration 0 trials
- Senile reticular retinal degeneration 0 trials
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Cone dystrophy 1, X-linked 0 trials
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Cone dystrophy 5, X-linked 0 trials
Most studied deeper sub-types
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New eye injection shows promise for rare Blindness-Causing gene mutation
Disease control CompletedThis early-stage study tested the safety of a new drug called VP-001, given as an injection into the eye, for people with a rare genetic eye disease (PRPF31 mutation) that causes vision loss. Six participants aged 12 and older received multiple doses. The main goal was to check f…
Phase 1 • Sponsor: PYC Therapeutics • Aim: Disease control
Last updated Jun 27, 2026 13:00 UTC
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New eye drug could save sight for millions with diabetes
Disease control CompletedThis study tested an eye injection called tarcocimab in 255 people with diabetic retinopathy, a diabetes complication that can damage vision. Participants received either the drug or a sham (fake) injection. The goal was to see if the drug improves the severity of the disease and…
Phase 3 • Sponsor: Kodiak Sciences Inc • Aim: Disease control
Last updated Jun 27, 2026 12:33 UTC
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Eye drug dosing showdown: can fewer injections still control wet AMD?
Disease control CompletedThis study compared two different dosing schedules of brolucizumab (Beovu) in 52 people with wet age-related macular degeneration (AMD) who had not responded well to previous treatment. Participants received the drug as an eye injection either on a fixed schedule or with adjustme…
Phase 4 • Sponsor: Novartis Pharmaceuticals • Aim: Disease control
Last updated Jun 27, 2026 07:51 UTC
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New eye injection shows promise for diabetic vision loss
Disease control CompletedThis phase 2 trial tested a new way to deliver dexamethasone directly to the back of the eye using tiny microspheres (OXU-001) compared to the standard Ozurdex implant. The study enrolled only 3 adults with diabetic macular edema to check safety and how well the treatment is tole…
Phase 2 • Sponsor: Oxular Limited • Aim: Disease control
Last updated Jun 26, 2026 13:03 UTC
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Eye scans may reveal hidden heart risks
Diagnosis CompletedThis study looked at whether a special eye scan (SS-OCTA) can detect signs of cardiovascular disease. Researchers compared retinal blood vessel changes to results from a standard carotid ultrasound in 42 adults. The goal was to see if the eye scan could predict the presence or se…
Sponsor: Northwestern University • Aim: Diagnosis
Last updated Jun 27, 2026 12:37 UTC