Respiratory tract infectious disorder

This study looks at health records of over 800,000 adults to see if the PCV20 vaccine reduces pneumonia cases. Researchers will compare pneumonia rates in people who got the vaccine versus those who did not. The goal is to measure how effective PCV20 is in adults aged 18 and olde…

This early-stage trial is testing a new mRNA vaccine called IN006 that targets respiratory syncytial virus (RSV). About 240 healthy adults aged 18 and older will receive either the vaccine or a placebo. The main goal is to check if the vaccine is safe and triggers an immune respo…

This study tests a new mRNA vaccine called IN006 against respiratory syncytial virus (RSV) in 500 healthy adults aged 60 and older. The vaccine is given as two different doses, with a booster after 12 or 24 months. Researchers will monitor safety and measure immune responses like…

This phase II trial tests whether bevacizumab, a drug that blocks blood vessel growth, can lengthen the time between surgeries for adults with recurrent respiratory papillomatosis (RRP), a rare condition causing wart-like growths in the airways. Participants receive 11 doses of t…

This study tests a fast point-of-care PCR test (Spotfire) that quickly identifies whether a respiratory infection is caused by a virus. The goal is to give ER doctors results faster so they can avoid prescribing antibiotics when they won't help. The trial enrolls 200 adults with …

This trial asks whether wearing a surgical mask every day can prevent acute respiratory infections like influenza and COVID-19. About 2,000 adults who normally don't wear masks will be randomly assigned to either wear a mask when outdoors or continue without one for 3–4 months du…

This study tests whether OM-85 (Broncho-Vaxom), a bacterial extract taken by mouth for 10 days each month, can reduce the number of respiratory infections in children aged 6 months to 5 years who have a history of wheezing. About 525 children will receive either OM-85 or a placeb…

This study tests whether placing HEPA air purifiers in primary school classrooms can reduce student absences caused by respiratory infections like colds and flu. About 72 schools in Norway will be randomly assigned to receive either working purifiers or sham devices. Researchers …

This study tests whether a pill made from dead bacteria (OM 85) can prevent lower respiratory tract infections in people aged 75+ living in nursing homes. Participants take the pill or a placebo for 10 days each month over 3 months. The goal is to see if the treatment reduces inf…

This study tests whether a virtual reality (VR) game can teach primary schoolchildren aged 6-12 better hygiene habits to prevent the spread of COVID-19 and other respiratory viruses. Over 2,000 children will either play the VR game for two weeks or receive standard education. Res…

This study tests whether a mix of two probiotics (Lactobacillus rhamnosus and Bifidobacterium breve) can reduce the severity and duration of cold symptoms in children aged 3 months to 6 years. 120 children with mild to moderate upper respiratory infections will receive either the…

This study tracks 80 adults with different smell disorders (like total loss, partial loss, or distorted smell) plus healthy volunteers over one year. Researchers use brain scans, smell tests, and questionnaires to see how the brain changes and how smell loss impacts mood and dail…

This study aims to understand how the immune system responds to a second infection with a mild bird flu virus (H10N7). Healthy adults who were infected with H10N7 in a previous study will be infected again and monitored closely in the hospital for 9 days. The goal is to learn mor…

This study tests two simple interventions for community pharmacies in Ghana: giving them personalized feedback on their antibiotic dispensing habits, and sending a legal reminder that dispensing antibiotics without a prescription is against the law. Researchers will measure wheth…

This study looks at whether air samplers placed in homes can detect viruses that cause colds and flu, and how that compares to standard nasal swabs. About 422 students and their families will participate. The goal is to better understand how respiratory viruses spread through hou…

This study is testing two new types of pulse oximeters—simple devices that measure oxygen levels—for babies and toddlers with pneumonia in Cape Town, South Africa. Researchers want to see if these devices help healthcare workers correctly identify children with low oxygen and ref…

This study compares new, less invasive ways to collect samples for respiratory virus testing—like a nasal wash or saliva—against the standard deep nose swab. Researchers want to see if these gentler methods work just as well and cause less pain. About 1,000 adults in the emergenc…

This project works to make sure children with common respiratory infections get the right antibiotics for the right amount of time. It involves over 259,000 kids across many clinics. The goal is to learn the best ways to help doctors follow antibiotic guidelines and reduce unnece…

This study places a rapid testing device in primary care clinics to help doctors quickly identify whether a cold-like illness is caused by a virus or bacteria. About 8,000 adults with symptoms like cough or runny nose will get a nasal swab, with results in 15 minutes. The goal is…

This study follows over 2,000 people and their pets in the Canton of Bern to learn how infections like COVID-19 spread and what social and environmental factors influence transmission. Participants provide samples and answer questionnaires over time. The goal is to improve pandem…

This study follows 2,500 people who visit freshwater beaches in Ontario, Manitoba, and Nova Scotia to see if contact with water containing blue-green algae (cyanobacteria) leads to stomach bugs, respiratory issues, or skin/eye infections. Researchers will also track illness in pe…