Resistant hypertension
MONDO:0100078A severe medical condition which is estimated to appear in 9-18% of hypertensive patients, in which treatment with 3 or more antihypertensive drugs including diuretics are ineffective.
Also known as: drug resistant hypertension
46 clinical trials for this condition and its sub-types, 42 tagged with Resistant hypertension itself.
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Implanted neck device aims to tame stubborn high blood pressure
Disease control OngoingResearchers are following people with high blood pressure who already received the Barostim Neo, a small implanted device that stimulates the body's own blood pressure sensors. The study tracks long-term safety and how well the device keeps blood pressure under control. Participa…
Sponsor: CVRx, Inc. • Aim: Disease control
Last updated Sep 12, 2026 00:00 UTC
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New surgical approach aims to tame resistant hypertension
Disease control OngoingThis early study is testing a new device called HyperQure that uses radiofrequency energy to disrupt nerves around the kidney arteries, which may help lower blood pressure. It involves 10 adults with resistant hypertension who are already taking 3 or more blood pressure medicatio…
Sponsor: DeepQure Inc. • Aim: Disease control
Last updated Aug 12, 2026 00:00 UTC
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New pill aims to tame stubborn high blood pressure
Disease control By invitation onlyThis study tests a new daily pill called QLS1410 in 260 adults whose high blood pressure remains high despite taking two or more medications. Participants will receive either QLS1410 or a placebo for 12 weeks. The main goal is to see if QLS1410 can lower systolic blood pressure m…
Phase 2 • Sponsor: Qilu Pharmaceutical Co., Ltd. • Aim: Disease control
Last updated Jun 27, 2026 12:37 UTC
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New device zaps kidney nerves to tame stubborn high blood pressure
Disease control By invitation onlyThis study is testing a device that uses radiofrequency energy to calm overactive kidney nerves, which can drive high blood pressure. It includes 1,000 people whose blood pressure stays high despite taking three or more medications, or who can't tolerate those drugs. Researchers …
Sponsor: Shanghai Golden Leaf MedTec Co. Ltd • Aim: Disease control
Last updated Jun 27, 2026 12:09 UTC
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Exercise showdown: interval vs. continuous training for stubborn high blood pressure
Disease control OngoingThis study compares two types of aerobic exercise—interval training and continuous training—over 4 months in 72 adults with resistant hypertension. The goal is to see which type better lowers 24-hour blood pressure and improves related health markers. Participants are randomly as…
Sponsor: Universidad Europea de Madrid • Aim: Disease control
Last updated Jun 26, 2026 18:44 UTC
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Stiff arteries may reveal Who's skipping blood pressure pills
Knowledge-focused OngoingThis study looks at 60 adults with resistant hypertension—high blood pressure that doesn't improve even with multiple medications. Researchers measure artery stiffness using a simple, non-invasive test to see if it can help identify patients who aren't taking their drugs as presc…
Sponsor: Institut National de la Santé Et de la Recherche Médicale, France • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:25 UTC