REM sleep behavior disorder

This study tests whether playing gentle sounds during deep sleep can slow the progression of Parkinson's disease in people at high risk. Participants with REM sleep behavior disorder or early Parkinson's will wear a headband and headphones for 18 months. Researchers will track ch…

This study looks at whether a protein linked to Parkinson's disease can be found in colon tissue samples taken during a routine colonoscopy. Researchers will compare samples from people with Parkinson's, those with REM sleep behavior disorder, and healthy individuals. The goal is…

This trial tests whether a smartphone app can help people with REM sleep behavior disorder, a condition that often precedes Parkinson's, become more physically active over two years. Participants receive personalized activity goals through the app and track their steps and exerci…

This study tests whether adalimumab, an anti-inflammatory drug, can prevent brain changes linked to Parkinson's disease in 108 people with REM sleep behavior disorder (RBD). RBD often precedes Parkinson's. Participants will receive adalimumab or a placebo every two weeks for two …

This study tests whether increasing physical activity through a motivational smartphone app can slow cognitive decline in people with isolated REM sleep behavior disorder (iRBD), an early sign of Parkinson's disease and related disorders. Researchers will enroll 130 participants …

This study tests whether L-theanine, a natural amino acid found in green tea, can improve REM sleep behavior disorder, gut function, and inflammation in people with early-stage Parkinson's disease. Participants take L-theanine or a placebo alongside a Mediterranean diet for four …

This study tests a behavioral (non-drug) treatment to reduce nightmares in adults with REM sleep behavior disorder (RBD). Participants attend 7 video sessions, with a family member joining 2 of them. The goal is to see if the therapy lowers nightmare frequency and severity.

This study tests a 4-week online course designed to help adults who experience parasomnias—unwanted sleep events like sleep terrors, sleepwalking, and nightmares. The course teaches safety planning, relaxation, and therapy techniques. Researchers will measure whether it reduces h…

This study looks at how the brain changes over time in people with REM sleep behavior disorder, a condition that often leads to Parkinson's disease or similar disorders. Researchers will use brain scans and thinking tests to track these changes in about 86 adults. The goal is to …

This study looks at people with REM sleep behavior disorder (RBD), a condition where people act out their dreams and which often leads to Parkinson's disease. Researchers will use advanced brain imaging, sleep tests, and physical exams to compare 50 people with RBD to 50 healthy …

This study explores whether methane gas produced by gut microbes is linked to the progression of Parkinson's disease and related conditions like dementia. Researchers will measure breath methane levels in 200 adults—including those with Parkinson's, those at high risk (REM sleep …

This study will use PET-MRI brain scans to compare the reward system in 44 Parkinson's patients, some of whom have a sleep disorder called RBD. The goal is to understand why some patients develop impulse control problems, like gambling or compulsive behaviors, as a side effect of…

This study follows 800 adults with synucleinopathies—diseases like Parkinson's, Lewy body dementia, and multiple system atrophy—to learn how they develop and change over time. Researchers will track symptoms, biological markers, and early signs like dizziness on standing or dream…

This observational study is recruiting 140 people to see if a history of concussions or playing contact sports is more common in those with REM sleep behavior disorder (RBD) compared to those without. RBD causes people to physically act out their dreams. Participants will answer …

This study looks at immune cells in the gut to understand how they might be linked to multiple sclerosis, Parkinson's disease, and REM sleep behavior disorder. Researchers will collect colon tissue samples from 100 adults during colonoscopy. The goal is to map these cells and the…

This study looks at pain in people with idiopathic REM sleep behavior disorder (iRBD), a condition that strongly increases the risk of developing Parkinson's disease. Researchers will compare pain levels and patterns between 24 participants with iRBD and a control group with narc…

This study follows 640 participants—including people with Parkinsonism, those with REM sleep behavior disorder, and healthy volunteers—for 5 years. Researchers will use brain scans, movement tests, voice analysis, and other tools to track how the disease progresses and improve di…

This study follows 650 people with early Parkinson's disease or a sleep condition called idiopathic REM sleep behavior disorder (iRBD). Researchers use brain scans, heart tests, and fluid samples to track changes over time. The goal is to better understand how these conditions de…

This study uses a new ultra-high-resolution PET scanner to take detailed pictures of the brain and spinal cord in 300 healthy volunteers and people with conditions like Alzheimer's, Parkinson's, ALS, and psychotic disorders. The goal is to understand how small brain regions chang…

This study is creating a national biobank of blood samples and health data from 230 people with Parkinson's disease or a related sleep disorder (REM sleep behavior disorder). Researchers will analyze the complete DNA of each participant to find rare genetic changes that may cause…

This observational study surveys 150 people with isolated REM sleep behavior disorder (iRBD) and their caregivers. iRBD causes people to act out dreams during sleep and is linked to future brain diseases. The study asks about their emotional well-being, access to information, and…

This study looks at sleep problems in people with Parkinson's disease and those with a sleep disorder called REM sleep behavior disorder (iRBD). Researchers will compare sleep quality among these groups and healthy volunteers using overnight sleep tests. The goal is to better und…

This study aims to understand how inflammation in the brain works in Parkinson's disease. Researchers will give a mild inflammatory compound (LPS) to 30 volunteers—some with Parkinson's, some with a sleep disorder linked to Parkinson's, and some healthy—and use special PET-MR bra…