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Scientists launch 5-Year study to unravel Parkinson's mysteries

NCT ID NCT07553845

Knowledge-focused Sponsor: Ruijin Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study follows 640 participants—including people with Parkinsonism, those with REM sleep behavior disorder, and healthy volunteers—for 5 years. Researchers will use brain scans, movement tests, voice analysis, and other tools to track how the disease progresses and improve diagnosis. The goal is to better understand the condition and find early signs of Parkinsonism.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this study could improve early diagnosis and understanding of Parkinsonism progression, potentially guiding future treatments.
What could go wrong
This is an observational study, not a treatment trial. It may not lead to direct benefits for participants, and results may take years to impact clinical practice.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 640 people

The number the study aims to enrol. It can still change while the study runs.

Started

May 2024

Expected to finish

May 2029

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Participants will include patients with Parkinsonism, patients with rapid eye movement sleep behavior disorder, and healthy controls. Patients will be mainly recruited from the inpatient wards of the Department of Neurology at Ruijin Hospital after diagnostic and eligibility screening. Healthy controls will be recruited mainly from patients' family members or the community.

Ages

31 to 79 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: For participants with rapid eye movement sleep behavior disorder: * Meets the diagnostic criteria for rapid eye movement sleep behavior disorder established by the American Academy of Sleep Medicine * Chinese citizen * Age \>30 years and \<80 years * Able to understand the study, show good compliance, and provide written informed consent personally or through a legal representative For participants with Parkinsonism: * Meets the diagnostic criteria for Parkinsonism established by the International Parkinson and Movement Disorder Society * Chinese citizen * Age \>30 years and \<80 years * Able to understand the study, show good compliance, and provide written informed consent personally or through a legal representative For healthy controls: * No neurodegenerative disease, no history of head trauma or head surgery, no history of stroke, epilepsy, tumor, or psychiatric disease * No metal implants or cardiac pacemaker * No severe chronic disease or severe hepatic or renal insufficiency * Chinese citizen * Age \>30 years and \<80 years * Education level of primary school or above * Able to understand the study, show good compliance, and provide written informed consent personally or through a legal representative Exclusion Criteria: * Significant cognitive impairment (MMSE ≤23) * Unable to sign the informed consent form or unable to complete study procedures for other reasons * Any other condition that, in the opinion of the investigator, makes the participant unsuitable for this study

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Conditions

The condition(s) this trial relates to.

parkinsonian disorder REM sleep behavior disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Parkinsonism Rem sleep behavior disorder

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Department of neurology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine

    RECRUITING

    Shanghai, 200025, China

More trials for these conditions

Other studies related to the condition(s) this trial covers.