Primary ovarian failure

Researchers are testing whether injecting a woman's own bone marrow cells into her ovaries can restore ovarian function in premature ovarian insufficiency, a condition where the ovaries stop working before age 40. Ten women with the diagnosis will receive the treatment, which inv…

This pilot trial tests whether a drug called G-CSF, given as a short course of injections, can improve markers of ovarian reserve in women aged 25-40 with premature ovarian insufficiency (POI). The main question is whether treatment can lower FSH levels, raise AMH, and increase a…

This early-phase trial tests whether injecting tiny particles called extracellular vesicles, derived from bone marrow stem cells, directly into the ovary is safe for women with premature ovarian failure. The study includes 10 women aged 20–38 who have had no menstrual period for …

This study tested a new technique to help women with primary ovarian insufficiency (early ovarian failure) become pregnant. Doctors removed one ovary, treated small pieces of it with drugs to wake up dormant eggs, and then transplanted the tissue back into the patient. After moni…

This Phase 3 trial tested a treatment called EryDex for people with ataxia telangiectasia (A-T), a rare genetic disease that affects movement and coordination. EryDex is a steroid (dexamethasone) packaged inside the patient's own red blood cells and given as an IV infusion every …

This study followed 86 women under 40 with premature ovarian failure (early menopause) who had received a one-time gene therapy using their own stem cells. The goal was to check long-term safety and see if hormone levels and fertility improved over 2.5 years. No new treatment was…

This early-stage study tested whether a single injection of stem cells from donated umbilical cords is safe for women with premature ovarian insufficiency (early menopause). Only 6 women took part, and the main goal was to check for side effects, not to prove it works. Researcher…

This study tested an experimental drug called AT-007 in 47 children aged 2 to 18 with Classic Galactosemia, a rare genetic disorder that makes it hard to break down a sugar called galactose. The goal was to see if the drug could improve behavior, daily living skills, and language…

This study tested whether platelet-rich plasma from umbilical cord blood can thicken the endometrium (uterine lining) in women with Asherman's syndrome or endometrial atrophy. Fifteen women received an injection of the plasma into the uterine wall during a hysteroscopy, along wit…

This study tested a program called Babble Boot Camp for babies with classic galactosemia, a rare condition that often causes speech and language problems. The program started when babies were 2 to 24 months old and involved weekly online coaching for parents from a speech therapi…

Ataxia-telangiectasia is a rare, inherited disease that damages the nervous system, skin, and immune system, and it has no cure. Researchers are testing sirolimus, an immune-suppressing drug, in children under 17 with the condition. The six participants take sirolimus by mouth fo…

This study tested an online nurse-led program to help young women who had breast cancer improve their sexual health, body image, and menopausal symptoms. 43 women who finished treatment within the last five years took part in eight weekly sessions. The program aimed to see if it …

This study tested whether paroxetine, a common antidepressant, can reduce hot flashes and night sweats in women who entered menopause after surgery. 90 women took either paroxetine or a placebo daily for 6 months. The goal was to see if paroxetine could be a safer alternative to …

This study investigates why some girls with Turner syndrome find it hard to make friends, read emotions, and control their feelings. Researchers will compare 35 girls with Turner syndrome to 35 girls with isolated growth hormone deficiency, all aged 7 to 16. Through puzzles, memo…

This study follows 135 women with premature ovarian failure (early menopause) to see if hormone replacement therapy improves their sexual quality of life. Participants fill out questionnaires about sexual function and well-being before starting treatment and again 6 months later.…

This study looked at gut and vaginal bacteria in 20 women with premature ovarian insufficiency (POI) and 20 healthy women of similar age. POI causes ovaries to stop working normally before age 40, affecting hormones and fertility. Researchers collected stool, vaginal swabs, blood…

This study looked at 51 women who had a stem cell transplant for acute leukemia as adults. Researchers wanted to find out how many had gynecological problems like early menopause, vaginal graft-versus-host disease, or cervical issues two years after transplant. They also checked …

This study looked at 112 people with known differences in their sex chromosomes (X and Y) to better understand how these variations affect health, especially infertility. Participants underwent physical exams, blood and urine tests, imaging, and sensory checks over about 5 days. …

This study looked at how a genetic test that checks 25 genes linked to hereditary cancers is used in clinics. Over 1,500 people with a personal or family history of cancer took part. Researchers collected blood samples and had participants fill out questionnaires over five years …

This study looked at 136 women to see if the age they entered menopause is linked to anxiety and depression. Researchers compared women with early menopause (before age 40) to those with natural menopause after 40. Participants filled out standard anxiety questionnaires during a …

This completed study looked back at the medical records of 74 adolescent girls aged 12 to 21 who had bone density scans. Researchers wanted to find out which girls are most at risk for low bone density (osteopenia or osteoporosis), especially those with missed periods or other gy…