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Could an antidepressant tame hot flashes without hormones?

NCT ID NCT06763484

Symptom relief Sponsor: Universidad Nacional Autonoma de Honduras Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 26, 2026 · Updated 1 time

Summary

This study tested whether paroxetine, a common antidepressant, can reduce hot flashes and night sweats in women who entered menopause after surgery. 90 women took either paroxetine or a placebo daily for 6 months. The goal was to see if paroxetine could be a safer alternative to hormone therapy, which carries risks like blood clots.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Paroxetine
What this could lead to
If it works, this could offer a non-hormonal option to ease hot flashes and night sweats for women who cannot take hormone therapy.
What could go wrong
This is a small, Phase 2 trial with only 90 participants. Paroxetine may cause side effects and might not work better than a placebo.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

90 people

The number who actually took part.

Started

Jan 2025

Finished

Sep 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 80 years

Sex

Female participants only

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients with surgical menopause attending IHSS outpatient clinic. * Patients with surgical menopause with presence of hot flashes and night sweats. * Surgical menopausal patients with episodes of anxiety and palpitations. * Patients with surgical menopause who receive treatment for 6 months with Paroxetine. * Patients who after reading and explanation of the Informed Consent agree to participate voluntarily. Exclusion Criteria: * Patients medicated with psychotropic drugs, including all sedatives and hypnotics. * Patients under treatment with Menopausal Hormone Therapy. * Patients with impaired hepatic or renal function. * Patients with unstable heart disease. * Patients with a history of self-destructive behaviors. * Patients with a history of clinical diagnosis or treatment for depression or any other psychiatric disorder (including substance abuse or alcohol disorders) and any other ongoing medical condition.

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Conditions

The condition(s) this trial relates to.

Hot Flashes premature menopause

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Hot flashes Menopause surgical Menopause syndrome

Contacts and locations

Locations

  • Instituto Hondureño de Seguridad Social

    Tegucigalpa, Francisco Morazán Department, 11101, Honduras

More trials for these conditions

Other studies related to the condition(s) this trial covers.