Primary ovarian failure
MONDO:0005387Absent or premature cessation of ovarian function due to a pathologic process originating within the ovaries.
Also known as: primary ovarian failure, female hypergonadotropic hypogonadism, hypergonadotrophic ovarian failure, hypergonadotropic hypogonadism, hypergonadotropic hypogonadism (female), premature menopause, premature ovarian failure, premature ovarian insufficiency
104 clinical trials for this condition and its sub-types, 53 tagged with Primary ovarian failure itself.
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Sub-types of Primary ovarian failure
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Inherited primary ovarian failure 2 trials · 48 incl. sub-types
41 sub-types
- Turner syndrome 29 trials Sub-types →
- Ataxia telangiectasia 11 trials Sub-types →
- Classic galactosemia 3 trials
- Trisomy X 3 trials
- 46 XX gonadal dysgenesis 1 trial Sub-types →
- Congenital lipoid adrenal hyperplasia due to STAR deficency 1 trial Sub-types →
- Premature ovarian failure 1 1 trial Sub-types →
- 46,XX ovarian dysgenesis-short stature syndrome 0 trials
- Perrault syndrome 0 trials Sub-types →
- Satoyoshi syndrome 0 trials
- X small rings 0 trials
- Aromatase deficiency 0 trials
- Blepharophimosis, ptosis, and epicanthus inversus syndrome 0 trials Sub-types →
- Osteosclerosis-ichthyosis-premature ovarian failure syndrome 0 trials
- Premature ovarian failure 10 0 trials
- Premature ovarian failure 11 0 trials
- Premature ovarian failure 12 0 trials
- Premature ovarian failure 13 0 trials
- Premature ovarian failure 14 0 trials
- Premature ovarian failure 15 0 trials
- Premature ovarian failure 16 0 trials
- Premature ovarian failure 17 0 trials
- Premature ovarian failure 18 0 trials
- Premature ovarian failure 19 0 trials
- Premature ovarian failure 20 0 trials
- Premature ovarian failure 21 0 trials
- Premature ovarian failure 22 0 trials
- Premature ovarian failure 23 0 trials
- Premature ovarian failure 24 0 trials
- Premature ovarian failure 25 0 trials
- Premature ovarian failure 26 0 trials
- Premature ovarian failure 2A 0 trials
- Premature ovarian failure 2B 0 trials
- Premature ovarian failure 3 0 trials
- Premature ovarian failure 4 0 trials
- Premature ovarian failure 5 0 trials
- Premature ovarian failure 6 0 trials
- Premature ovarian failure 7 0 trials
- Premature ovarian failure 8 0 trials
- Premature ovarian failure 9 0 trials
- Tetrasomy X 0 trials
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Premature menopause 22 trials
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Acquired primary ovarian failure 1 trial
Most studied deeper sub-types
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Continued EryDex treatment studied in rare neurological disorder
Disease control Stopped earlyThis study offered continued treatment with EryDex to 101 people with ataxia telangiectasia (A-T) who had finished a previous trial. The main goal was to monitor safety, including side effects and serious events. The study was terminated early, and it did not aim to cure the dise…
Phase 3 • Sponsor: Quince Therapeutics S.p.A. • Aim: Disease control
Last updated Jun 27, 2026 12:29 UTC
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Experimental drug shows promise for rare genetic disorder
Disease control Stopped earlyThis Phase II trial tested a drug called N-Acetyl-L-Leucine (IB1001) in 17 people with Ataxia-Telangiectasia, a rare genetic disease that affects movement and immunity. The study aimed to see if the drug could improve symptoms and slow the disease over time. The trial was termina…
Phase 2 • Sponsor: IntraBio Inc • Aim: Disease control
Last updated Jun 27, 2026 12:00 UTC
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Ultrasound could uncover hidden vascular risks in turner syndrome
Knowledge-focused Stopped earlyThis study is looking at whether yearly ultrasound scans can detect blood vessel abnormalities throughout the body in women with Turner syndrome, not just in the heart area. Turner syndrome is a genetic condition that increases the risk of serious vascular problems, which can sho…
Sponsor: University Hospital, Strasbourg, France • Aim: Knowledge-focused
Last updated Aug 23, 2026 00:00 UTC