Pneumocystosis
MONDO:0019121Human pneumocystosis is caused by an infectious agent, which (after recent nomenclature and taxonomy revisions) is now classed as the fungus Pneumocystis jiroveci. The prevalence is unknown. Pneumocystis jiroveci is an opportunistic infectious agent, developing in immunosuppressed patients. It is an air-borne infection, localized to the lungs. However, extrapulmonary involvement is seen in AIDS patients. The disease manifests progressively with coughing, respiratory problems (dyspnea) and fever, followed by acute respiratory insufficiency and death within a few weeks in untreated cases. The most reliable diagnostic method is bronchoalveolar lavage. The treatment of choice is cotrimoxazole.
Also known as: PCP, PJP, Pneumocystis, Pneumocystis Pneumonia, Pneumocystis carinii pneumonia, Pneumocystis jirovecii pneumonia, Pneumocystis pneumonia, pneumocystosis
69 clinical trials for this condition and its sub-types, 19 tagged with Pneumocystosis itself.
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Could a lower dose of antibiotics be safer and just as effective for this lung infection?
Disease control Recruiting nowThis study is for people with a weakened immune system who have a serious lung infection called PCP. The standard treatment often causes bad side effects. Researchers want to see if a lower dose of the antibiotic TMP-SMX works just as well but with fewer side effects. About 416 a…
Phase 3 • Sponsor: Todd C. Lee MD MPH FIDSA • Aim: Disease control
Last updated Jun 27, 2026 09:07 UTC
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Kidney transplant patients sought for study to prevent deadly lung infection
Disease control Recruiting nowThis study looks at how long kidney transplant patients should take a common antibiotic (TMP-SMX) to prevent a serious lung infection called PJP. About 450 participants will be randomly assigned to different treatment durations. The goal is to find the safest and most effective l…
Sponsor: Anhui Provincial Hospital • Aim: Disease control
Last updated Jun 27, 2026 08:04 UTC
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New score could help doctors spot fungal pneumonia faster
Diagnosis Recruiting nowThis study aims to create and test a clinical prediction score called FUNGAL-P to help doctors identify fungal pneumonia early in adults who come to the hospital with pneumonia. Researchers will analyze medical records from past patients and then test the score on new patients to…
Sponsor: Azienda Ospedaliero-Universitaria Careggi • Aim: Diagnosis
Last updated Jul 04, 2026 00:00 UTC
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Could a simple swab replace a lung scope for pneumocystis diagnosis?
Diagnosis Recruiting nowThis study is testing whether a mouthwash or a nasal swab can accurately detect pneumocystis pneumonia (PcP) in immunocompromised patients. Currently, diagnosis often requires a bronchoscopy, which is invasive and uncomfortable. Researchers will compare the new non-invasive metho…
Sponsor: Assistance Publique - Hôpitaux de Paris • Aim: Diagnosis
Last updated Jun 27, 2026 12:23 UTC
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New DNA test could speed up diagnosis of three major parasitic infections
Diagnosis Recruiting nowThis study aims to see if a new PCR-based test can diagnose malaria, leishmania, and pneumocystis infections faster and more accurately than current methods. Researchers will analyze about 200 stored samples from patients. The goal is to improve diagnosis and species identificati…
Sponsor: Fondazione IRCCS Policlinico San Matteo di Pavia • Aim: Diagnosis
Last updated Jun 27, 2026 08:02 UTC