Peripheral neuropathy
MONDO:0005244A disorder affecting the peripheral nervous system. It manifests with pain, tingling, numbness, and muscle weakness. It may be the result of physical injury, toxic substances, viral diseases, diabetes, renal failure, cancer, and drugs.
Also known as: neuropathy, peripheral nerve disorder, peripheral neuropathy
1469 clinical trials for this condition and its sub-types, 93 tagged with Peripheral neuropathy itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Sub-types of Peripheral neuropathy
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Hereditary peripheral neuropathy 6 trials · 478 incl. sub-types
65 sub-types
- Carpal tunnel syndrome 165 trials Sub-types →
- Charcot-Marie-Tooth disease 51 trials · 77 incl. sub-types Sub-types →
- Familial amyloid neuropathy 52 trials · 54 incl. sub-types Sub-types →
- Hereditary sensory and autonomic neuropathy 52 trials · 54 incl. sub-types Sub-types →
- Proximal spinal muscular atrophy 14 trials · 42 incl. sub-types Sub-types →
- Metachromatic leukodystrophy 20 trials Sub-types →
- Krabbe disease 15 trials Sub-types →
- Sandhoff disease 13 trials Sub-types →
- Tay-Sachs disease 13 trials Sub-types →
- Chediak-Higashi syndrome 9 trials
- Leigh syndrome 9 trials Sub-types →
- Peroxisome biogenesis disorder 4 trials · 8 incl. sub-types Sub-types →
- Adrenomyeloneuropathy 7 trials
- Cerebrotendinous xanthomatosis 6 trials
- Kearns-Sayre syndrome 5 trials
- Distal hereditary motor neuropathy 0 trials · 4 incl. sub-types Sub-types →
- Hereditary neuropathy with liability to pressure palsies 4 trials
- Mitochondrial neurogastrointestinal encephalomyopathy 4 trials Sub-types →
- Ornithine aminotransferase deficiency 4 trials
- Pyruvate dehydrogenase deficiency 2 trials · 4 incl. sub-types Sub-types →
- NARP syndrome 3 trials
- Biotinidase deficiency 3 trials
- Coenzyme Q10 deficiency 3 trials Sub-types →
- Giant axonal neuropathy 2 trials · 3 incl. sub-types Sub-types →
- Hereditary motor and sensory neuropathy 3 trials Sub-types →
- Methylmalonic aciduria and homocystinuria type cblC 3 trials
- Mitochondrial DNA depletion syndrome 4a 3 trials
- Abetalipoproteinemia 2 trials
- Fumaric aciduria 2 trials
- Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy 2 2 trials
- Niemann-Pick disease type B 1 trial
- PRPS1 deficiency disorder 1 trial
- Adult polyglucosan body disease 1 trial
- Familial isolated deficiency of vitamin E 1 trial
- Homocystinuria due to methylene tetrahydrofolate reductase deficiency 1 trial
- Long chain 3-hydroxyacyl-CoA dehydrogenase deficiency 1 trial
- Neuropathy, congenital hypomelinating 0 trials · 1 incl. sub-types Sub-types →
- Sensory ataxic neuropathy, dysarthria, and ophthalmoparesis 1 trial Sub-types →
- Charcot-Marie-Tooth disease type 5 0 trials
- EMILIN-1-related connective tissue disease 0 trials
- Finnish type amyloidosis 0 trials
- PHARC syndrome 0 trials
- VPS13A-related neurodegenerative disease 0 trials
- Amyotrophic neuralgia 0 trials
- Ataxia - oculomotor apraxia type 4 0 trials
- Attenuated Chédiak-Higashi syndrome 0 trials
- Beta-mannosidosis 0 trials
- Cataract-growth hormone deficiency-sensory neuropathy-sensorineural hearing loss-skeletal dysplasia syndrome 0 trials
- Congenital trigeminal anesthesia 0 trials
- Familial episodic pain syndrome 0 trials Sub-types →
- Familial recurrent peripheral facial palsy 0 trials
- Hereditary motor and sensory neuropathy, Okinawa type 0 trials Sub-types →
- Hereditary sensory and autonomic neuropathy with spastic paraplegia 0 trials
- Infantile axonal neuropathy 0 trials
- Meralgia paraesthetica, familial 0 trials
- Neurodegeneration with brain iron accumulation 2A 0 trials
- Neuropathy with hearing impairment 0 trials
- Neuropathy, hereditary sensory and autonomic, type IId 0 trials
- Non-progressive predominantly posterior cavitating leukoencephalopathy with peripheral neuropathy 0 trials
- Optic atrophy-ataxia-peripheral neuropathy-global developmental delay syndrome 0 trials
- Oxoglutaricaciduria 0 trials
- Peripheral motor neuropathy, childhood-onset, biotin-responsive 0 trials
- Primary CD59 deficiency 0 trials
- Progressive demyelinating neuropathy with bilateral striatal necrosis 0 trials
- Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy 1 0 trials
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Neuralgia 238 trials · 383 incl. sub-types
5 sub-types
- Sciatica 46 trials · 68 incl. sub-types Sub-types →
- Cranial neuralgia 0 trials · 53 incl. sub-types Sub-types →
- Post-infectious neuralgia 0 trials · 33 incl. sub-types Sub-types →
- Pudendal neuralgia 9 trials
- Familial episodic pain syndrome 0 trials Sub-types →
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Nerve compression syndrome 24 trials · 207 incl. sub-types
3 sub-types
- Carpal tunnel syndrome 165 trials Sub-types →
- Piriformis syndrome 25 trials
- Meralgia paresthetica 5 trials Sub-types →
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Diabetic neuropathy 181 trials · 192 incl. sub-types
2 sub-types
- Diabetic polyneuropathy 50 trials
- Diabetic autonomic neuropathy 7 trials
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Chemotherapy-induced neuropathy 171 trials
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Polyneuropathy 32 trials · 132 incl. sub-types
10 sub-types
- Polyradiculoneuropathy 1 trial · 64 incl. sub-types Sub-types →
- Chronic polyneuropathy 0 trials · 62 incl. sub-types Sub-types →
- Demyelinating polyneuropathy 2 trials · 62 incl. sub-types Sub-types →
- Critical illness polyneuropathy 39 trials
- Polyneuritis 3 trials
- Toxic polyneuropathy 1 trial · 3 incl. sub-types Sub-types →
- Idiopathic progressive polyneuropathy 0 trials
- Organophosphate-induced delayed polyneuropathy 0 trials
- Paraneoplastic polyneuropathy 0 trials
- Polyneuropathy in collagen vascular disease 0 trials
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Mononeuropathy 4 trials · 111 incl. sub-types
7 sub-types
- Sciatic neuropathy 9 trials · 72 incl. sub-types Sub-types →
- Ulnar neuropathy 7 trials · 21 incl. sub-types Sub-types →
- Peroneal neuropathy 9 trials
- Femoral neuropathy 7 trials
- Radial neuropathy 1 trial Sub-types →
- Tibial neuropathy 0 trials · 1 incl. sub-types Sub-types →
- Mononeuritis simplex 0 trials Sub-types →
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Acquired peripheral neuropathy 0 trials · 95 incl. sub-types
12 sub-types
- Cranial neuralgia 0 trials · 53 incl. sub-types Sub-types →
- Multifocal motor neuropathy 9 trials
- Pudendal neuralgia 9 trials
- POEMS syndrome 8 trials
- Polyneuropathy associated with IgM monoclonal gammapathy with anti-MAG 8 trials
- Non-recovering obstetric brachial plexus lesion 6 trials
- Anterior cutaneous nerve entrapment syndrome 2 trials
- Radiation-induced plexopathy 1 trial
- CANOMAD syndrome 0 trials
- Axonal polyneuropathy associated with IgG/IgM/IgA monoclonal gammopathy 0 trials
- Neuralgic amyotrophy 0 trials
- Simple cryoglobulinemia 0 trials
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Nerve plexus disorder 0 trials · 75 incl. sub-types
4 sub-types
- Brachial plexus neuropathy 13 trials · 72 incl. sub-types Sub-types →
- Lumbosacral plexus lesion 0 trials · 2 incl. sub-types Sub-types →
- Radiation-induced plexopathy 1 trial
- Nerve plexus neoplasm 0 trials Sub-types →
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Sensory peripheral neuropathy 4 trials · 58 incl. sub-types
1 sub-type
- Hereditary sensory and autonomic neuropathy 52 trials · 54 incl. sub-types Sub-types →
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Traumatic neuropathy 55 trials
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Neuritis 18 trials · 29 incl. sub-types
7 sub-types
- Vestibular neuronitis 9 trials
- Polyneuritis 3 trials
- Brachial plexus neuritis 0 trials Sub-types →
- Mononeuritis simplex 0 trials Sub-types →
- Motor nerve neuritis 0 trials Sub-types →
- Neuritis of upper limb 0 trials Sub-types →
- Neuroretinitis 0 trials
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Peripheral nerve lesion 1 trial · 12 incl. sub-types
4 sub-types
- Femoral neuropathy 7 trials
- Lesion of sciatic nerve 2 trials Sub-types →
- Ulnar nerve lesion 2 trials
- Radial nerve lesion 0 trials
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Autonomic neuropathy 7 trials · 10 incl. sub-types
2 sub-types
- Diabetic autonomic neuropathy 7 trials
- Horner syndrome 0 trials Sub-types →
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Chronic idiopathic neuropathy 5 trials
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Neuropathy, small fiber 4 trials
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Axonal neuropathy 1 trial · 4 incl. sub-types
3 sub-types
- Giant axonal neuropathy 2 trials · 3 incl. sub-types Sub-types →
- Congenital axonal neuropathy with encephalopathy 0 trials
- Infantile axonal neuropathy 0 trials
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Infectious neuropathy 2 trials
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Vasculitic neuropathy 2 trials
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Autoimmune neuropathy 1 trial
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Ischemic neuropathy 1 trial
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Sarcoid neuropathy 1 trial
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Motor peripheral neuropathy 0 trials · 1 incl. sub-types
9 sub-types
- Charcot-Marie-Tooth disease axonal type 2C 1 trial
- Charcot-Marie-Tooth disease type 4G 0 trials
- Charcot-Marie-Tooth disease type 5 0 trials
- Glossopharyngeal motor neuropathy 0 trials
- Hereditary motor and sensory neuropathy, Okinawa type 0 trials Sub-types →
- Motor nerve neuritis 0 trials Sub-types →
- Neuropathy, hereditary motor and sensory, type 6A 0 trials
- Neuropathy, hereditary motor and sensory, type 6B 0 trials
- Peripheral motor neuropathy, childhood-onset, biotin-responsive 0 trials
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Radiation-induced neuropathy 0 trials · 1 incl. sub-types
1 sub-type
- Radiation-induced plexopathy 1 trial
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Idiopathic small fibers neuropathy 0 trials
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Neuropathy in cryoglobulinemia 0 trials
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Neuropathy in endocrine disorder 0 trials
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Uremic neuropathy 0 trials
Most studied deeper sub-types
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Promising nerve pain drug trial for MGUS patients withdrawn before start
Disease control CancelledThis study aimed to test if daratumumab could improve nerve damage (peripheral neuropathy) in people with a blood condition called MGUS. Participants would have received weekly injections for two months, then biweekly for four more months. However, the trial was withdrawn before …
Phase 2 • Sponsor: Georgetown University • Aim: Disease control
Last updated Jun 27, 2026 07:52 UTC
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New screening tool aims to catch diabetic nerve damage early
Diagnosis OngoingThis study tests a short questionnaire called ACT to see if it can accurately detect nerve damage in the feet and legs of people with diabetes. Researchers will compare it to standard screening tools and an eye test that looks at tiny nerve fibers. The goal is to find a simple, n…
Sponsor: Weill Cornell Medical College in Qatar • Aim: Diagnosis
Last updated Jun 26, 2026 14:24 UTC
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Wearable insoles warn of foot pressure to stop diabetic ulcers
Prevention OngoingThis trial tests a wearable insole system that monitors foot pressure, temperature, and movement, giving real-time alerts to help users shift weight and avoid injury. The study includes people with type 1 or 2 diabetes who have nerve damage and a recent history of healed foot ulc…
Sponsor: Johns Hopkins University • Aim: Prevention
Last updated Jul 16, 2026 00:00 UTC
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New pill aims to stop chemo from stealing hearing
Prevention CancelledThis study was designed to test whether an oral drug called SPI-1005 could prevent hearing loss and ringing in the ears caused by platinum-based chemotherapy. It was planned for adults with advanced lung or head and neck cancer. The study was withdrawn before enrolling any partic…
Phase 2 • Sponsor: Sound Pharmaceuticals, Incorporated • Aim: Prevention
Last updated Jun 27, 2026 13:01 UTC
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Cold hands, healthy nerves? study tests cryotherapy to block chemo side effect
Prevention PausedThis study tests whether wearing cold gloves during chemotherapy can prevent peripheral neuropathy (nerve damage causing numbness, tingling, or pain) in colon cancer patients. Forty adults with stage III colon cancer who are about to start a common chemo regimen (CAPOX) will be r…
Sponsor: NYU Langone Health • Aim: Prevention
Last updated Jun 27, 2026 09:10 UTC
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Elastic band exercises may stop diabetic foot ulcers before they start
Prevention OngoingThis study looks at whether foot and ankle exercises using elastic bands can help prevent diabetic foot ulcers in people with diabetic neuropathy. About 80 participants with type 2 diabetes and nerve damage in their feet will do these exercises. Researchers will track how many ul…
Sponsor: St Elisabeth School Health Science • Aim: Prevention
Last updated Jun 27, 2026 07:58 UTC
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Massage may ease chemo nerve damage
Symptom relief OngoingThis study looks at whether massage therapy can reduce nerve problems like pain, numbness, and tingling caused by chemotherapy in people with breast or digestive system cancers. About 90 participants will receive massage sessions to see if it improves symptoms and quality of life…
Sponsor: M.D. Anderson Cancer Center • Aim: Symptom relief
Last updated Sep 20, 2026 00:00 UTC
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Brain training offers new hope for chemo nerve pain
Symptom relief OngoingThis study tests whether a non-invasive therapy called neurofeedback can help people with chemotherapy-induced nerve pain learn to change their own brain waves to feel less pain. About 80 participants will be assigned to either receive neurofeedback training or a control conditio…
Sponsor: M.D. Anderson Cancer Center • Aim: Symptom relief
Last updated Aug 13, 2026 00:00 UTC
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Acupuncture needles take on chemo nerve pain in major trial
Symptom relief OngoingThis study tests if acupuncture can reduce nerve pain caused by chemotherapy in cancer survivors. About 255 people who finished chemo at least three months ago will receive either real or sham acupuncture. The goal is to see if this drug-free approach can ease pain and improve da…
Sponsor: Dana-Farber Cancer Institute • Aim: Symptom relief
Last updated Jul 24, 2026 00:00 UTC
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Scrambler therapy offers hope for young cancer survivors with nerve pain
Symptom relief OngoingThis study looks at whether Scrambler therapy can safely reduce painful nerve damage caused by chemotherapy in adolescents and young adults (ages 15-39) who have finished active cancer treatment. Participants are randomly assigned to receive the therapy right away or after a wait…
Sponsor: M.D. Anderson Cancer Center • Aim: Symptom relief
Last updated Jul 10, 2026 00:00 UTC
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New nerve patch could ease pain after biopsy
Symptom relief OngoingThis study tests a biodegradable tube that is placed over a cut nerve during a leg biopsy. The goal is to see if it is safe and reduces common side effects like pain, redness, and swelling. Twenty adults with various nerve conditions are taking part, and half will get the tube wh…
Sponsor: Mayo Clinic • Aim: Symptom relief
Last updated Jun 27, 2026 12:28 UTC
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Micro-Implant zaps nerve pain: new hope for chronic sufferers?
Symptom relief OngoingThis study tests a small, implantable device that stimulates nerves to relieve chronic pain after injury or surgery. About 185 adults with peripheral neuralgia will either receive the stimulator plus standard medical care or standard care alone. The goal is to see if the device p…
Sponsor: Nalu Medical, Inc. • Aim: Symptom relief
Last updated Jun 27, 2026 09:11 UTC
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Yoga vs. nerve pain: could stretching replace pills for chemo side effects?
Symptom relief OngoingThis study tests whether yoga can reduce nerve pain caused by chemotherapy in cancer survivors. About 227 participants will either take yoga classes twice a week for 8 weeks, attend educational sessions, or receive standard care. Researchers will measure pain, balance, fall risk,…
Sponsor: Dana-Farber Cancer Institute • Aim: Symptom relief
Last updated Jun 27, 2026 09:02 UTC
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Magnetic pulses to the brain may soothe chemo nerve damage
Symptom relief OngoingThis study tests if a non-invasive treatment called repetitive transcranial magnetic stimulation (rTMS) can reduce nerve pain caused by oxaliplatin chemotherapy in people with stage I-IV cancer. rTMS uses magnetic pulses on the scalp to change brain activity. The trial includes 5…
Sponsor: M.D. Anderson Cancer Center • Aim: Symptom relief
Last updated Jun 27, 2026 07:54 UTC
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Can simple nerve stretches ease diabetic burning pain?
Symptom relief By invitation onlyThis study tests two types of nerve stretches—active (patient-controlled) and passive (therapist-applied)—to see which better reduces burning pain, improves muscle strength, and increases joint movement in people with diabetic neuropathy. Sixty adults aged 40 to 65 with diabetes …
Sponsor: Dow University of Health Sciences • Aim: Symptom relief
Last updated Jun 26, 2026 12:43 UTC
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Researchers track rare nerve disease to unlock future treatments
Knowledge-focused OngoingThis study follows 20 people with a rare nerve disease called CMT4J for up to 2 years. Researchers will track symptoms and health changes to better understand how the disease progresses. The goal is to find better ways to measure the disease, which could help design future treatm…
Sponsor: Elpida Therapeutics SPC • Aim: Knowledge-focused
Last updated Jul 10, 2026 00:00 UTC
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Pandemic's toll on cancer patients with neuropathy under the microscope
Knowledge-focused OngoingThis study looks at how the COVID-19 pandemic impacted the quality of life of 274 cancer patients who also have neuropathy (nerve pain). All participants had taken part in earlier clinical trials. Researchers want to see if there are differences between those who received a brain…
Sponsor: M.D. Anderson Cancer Center • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:25 UTC
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New eye test could unlock secrets of ocular pain
Knowledge-focused PausedThis study looks at how well a new test called quantitative sensory testing (QST) can measure nerve function in the eye. Researchers will use heat, cold, and vibration to see how people with dry eye disease or corneal nerve damage respond. The goal is to better understand eye pai…
Sponsor: Tufts Medical Center • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:09 UTC