Peripheral neuropathy
MONDO:0005244A disorder affecting the peripheral nervous system. It manifests with pain, tingling, numbness, and muscle weakness. It may be the result of physical injury, toxic substances, viral diseases, diabetes, renal failure, cancer, and drugs.
Also known as: neuropathy, peripheral nerve disorder, peripheral neuropathy
1469 clinical trials for this condition and its sub-types, 93 tagged with Peripheral neuropathy itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Sub-types of Peripheral neuropathy
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Hereditary peripheral neuropathy 6 trials · 478 incl. sub-types
65 sub-types
- Carpal tunnel syndrome 165 trials Sub-types →
- Charcot-Marie-Tooth disease 51 trials · 77 incl. sub-types Sub-types →
- Familial amyloid neuropathy 52 trials · 54 incl. sub-types Sub-types →
- Hereditary sensory and autonomic neuropathy 52 trials · 54 incl. sub-types Sub-types →
- Proximal spinal muscular atrophy 14 trials · 42 incl. sub-types Sub-types →
- Metachromatic leukodystrophy 20 trials Sub-types →
- Krabbe disease 15 trials Sub-types →
- Sandhoff disease 13 trials Sub-types →
- Tay-Sachs disease 13 trials Sub-types →
- Chediak-Higashi syndrome 9 trials
- Leigh syndrome 9 trials Sub-types →
- Peroxisome biogenesis disorder 4 trials · 8 incl. sub-types Sub-types →
- Adrenomyeloneuropathy 7 trials
- Cerebrotendinous xanthomatosis 6 trials
- Kearns-Sayre syndrome 5 trials
- Distal hereditary motor neuropathy 0 trials · 4 incl. sub-types Sub-types →
- Hereditary neuropathy with liability to pressure palsies 4 trials
- Mitochondrial neurogastrointestinal encephalomyopathy 4 trials Sub-types →
- Ornithine aminotransferase deficiency 4 trials
- Pyruvate dehydrogenase deficiency 2 trials · 4 incl. sub-types Sub-types →
- NARP syndrome 3 trials
- Biotinidase deficiency 3 trials
- Coenzyme Q10 deficiency 3 trials Sub-types →
- Giant axonal neuropathy 2 trials · 3 incl. sub-types Sub-types →
- Hereditary motor and sensory neuropathy 3 trials Sub-types →
- Methylmalonic aciduria and homocystinuria type cblC 3 trials
- Mitochondrial DNA depletion syndrome 4a 3 trials
- Abetalipoproteinemia 2 trials
- Fumaric aciduria 2 trials
- Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy 2 2 trials
- Niemann-Pick disease type B 1 trial
- PRPS1 deficiency disorder 1 trial
- Adult polyglucosan body disease 1 trial
- Familial isolated deficiency of vitamin E 1 trial
- Homocystinuria due to methylene tetrahydrofolate reductase deficiency 1 trial
- Long chain 3-hydroxyacyl-CoA dehydrogenase deficiency 1 trial
- Neuropathy, congenital hypomelinating 0 trials · 1 incl. sub-types Sub-types →
- Sensory ataxic neuropathy, dysarthria, and ophthalmoparesis 1 trial Sub-types →
- Charcot-Marie-Tooth disease type 5 0 trials
- EMILIN-1-related connective tissue disease 0 trials
- Finnish type amyloidosis 0 trials
- PHARC syndrome 0 trials
- VPS13A-related neurodegenerative disease 0 trials
- Amyotrophic neuralgia 0 trials
- Ataxia - oculomotor apraxia type 4 0 trials
- Attenuated Chédiak-Higashi syndrome 0 trials
- Beta-mannosidosis 0 trials
- Cataract-growth hormone deficiency-sensory neuropathy-sensorineural hearing loss-skeletal dysplasia syndrome 0 trials
- Congenital trigeminal anesthesia 0 trials
- Familial episodic pain syndrome 0 trials Sub-types →
- Familial recurrent peripheral facial palsy 0 trials
- Hereditary motor and sensory neuropathy, Okinawa type 0 trials Sub-types →
- Hereditary sensory and autonomic neuropathy with spastic paraplegia 0 trials
- Infantile axonal neuropathy 0 trials
- Meralgia paraesthetica, familial 0 trials
- Neurodegeneration with brain iron accumulation 2A 0 trials
- Neuropathy with hearing impairment 0 trials
- Neuropathy, hereditary sensory and autonomic, type IId 0 trials
- Non-progressive predominantly posterior cavitating leukoencephalopathy with peripheral neuropathy 0 trials
- Optic atrophy-ataxia-peripheral neuropathy-global developmental delay syndrome 0 trials
- Oxoglutaricaciduria 0 trials
- Peripheral motor neuropathy, childhood-onset, biotin-responsive 0 trials
- Primary CD59 deficiency 0 trials
- Progressive demyelinating neuropathy with bilateral striatal necrosis 0 trials
- Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy 1 0 trials
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Neuralgia 238 trials · 383 incl. sub-types
5 sub-types
- Sciatica 46 trials · 68 incl. sub-types Sub-types →
- Cranial neuralgia 0 trials · 53 incl. sub-types Sub-types →
- Post-infectious neuralgia 0 trials · 33 incl. sub-types Sub-types →
- Pudendal neuralgia 9 trials
- Familial episodic pain syndrome 0 trials Sub-types →
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Nerve compression syndrome 24 trials · 207 incl. sub-types
3 sub-types
- Carpal tunnel syndrome 165 trials Sub-types →
- Piriformis syndrome 25 trials
- Meralgia paresthetica 5 trials Sub-types →
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Diabetic neuropathy 181 trials · 192 incl. sub-types
2 sub-types
- Diabetic polyneuropathy 50 trials
- Diabetic autonomic neuropathy 7 trials
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Chemotherapy-induced neuropathy 171 trials
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Polyneuropathy 32 trials · 132 incl. sub-types
10 sub-types
- Polyradiculoneuropathy 1 trial · 64 incl. sub-types Sub-types →
- Chronic polyneuropathy 0 trials · 62 incl. sub-types Sub-types →
- Demyelinating polyneuropathy 2 trials · 62 incl. sub-types Sub-types →
- Critical illness polyneuropathy 39 trials
- Polyneuritis 3 trials
- Toxic polyneuropathy 1 trial · 3 incl. sub-types Sub-types →
- Idiopathic progressive polyneuropathy 0 trials
- Organophosphate-induced delayed polyneuropathy 0 trials
- Paraneoplastic polyneuropathy 0 trials
- Polyneuropathy in collagen vascular disease 0 trials
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Mononeuropathy 4 trials · 111 incl. sub-types
7 sub-types
- Sciatic neuropathy 9 trials · 72 incl. sub-types Sub-types →
- Ulnar neuropathy 7 trials · 21 incl. sub-types Sub-types →
- Peroneal neuropathy 9 trials
- Femoral neuropathy 7 trials
- Radial neuropathy 1 trial Sub-types →
- Tibial neuropathy 0 trials · 1 incl. sub-types Sub-types →
- Mononeuritis simplex 0 trials Sub-types →
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Acquired peripheral neuropathy 0 trials · 95 incl. sub-types
12 sub-types
- Cranial neuralgia 0 trials · 53 incl. sub-types Sub-types →
- Multifocal motor neuropathy 9 trials
- Pudendal neuralgia 9 trials
- POEMS syndrome 8 trials
- Polyneuropathy associated with IgM monoclonal gammapathy with anti-MAG 8 trials
- Non-recovering obstetric brachial plexus lesion 6 trials
- Anterior cutaneous nerve entrapment syndrome 2 trials
- Radiation-induced plexopathy 1 trial
- CANOMAD syndrome 0 trials
- Axonal polyneuropathy associated with IgG/IgM/IgA monoclonal gammopathy 0 trials
- Neuralgic amyotrophy 0 trials
- Simple cryoglobulinemia 0 trials
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Nerve plexus disorder 0 trials · 75 incl. sub-types
4 sub-types
- Brachial plexus neuropathy 13 trials · 72 incl. sub-types Sub-types →
- Lumbosacral plexus lesion 0 trials · 2 incl. sub-types Sub-types →
- Radiation-induced plexopathy 1 trial
- Nerve plexus neoplasm 0 trials Sub-types →
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Sensory peripheral neuropathy 4 trials · 58 incl. sub-types
1 sub-type
- Hereditary sensory and autonomic neuropathy 52 trials · 54 incl. sub-types Sub-types →
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Traumatic neuropathy 55 trials
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Neuritis 18 trials · 29 incl. sub-types
7 sub-types
- Vestibular neuronitis 9 trials
- Polyneuritis 3 trials
- Brachial plexus neuritis 0 trials Sub-types →
- Mononeuritis simplex 0 trials Sub-types →
- Motor nerve neuritis 0 trials Sub-types →
- Neuritis of upper limb 0 trials Sub-types →
- Neuroretinitis 0 trials
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Peripheral nerve lesion 1 trial · 12 incl. sub-types
4 sub-types
- Femoral neuropathy 7 trials
- Lesion of sciatic nerve 2 trials Sub-types →
- Ulnar nerve lesion 2 trials
- Radial nerve lesion 0 trials
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Autonomic neuropathy 7 trials · 10 incl. sub-types
2 sub-types
- Diabetic autonomic neuropathy 7 trials
- Horner syndrome 0 trials Sub-types →
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Chronic idiopathic neuropathy 5 trials
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Neuropathy, small fiber 4 trials
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Axonal neuropathy 1 trial · 4 incl. sub-types
3 sub-types
- Giant axonal neuropathy 2 trials · 3 incl. sub-types Sub-types →
- Congenital axonal neuropathy with encephalopathy 0 trials
- Infantile axonal neuropathy 0 trials
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Infectious neuropathy 2 trials
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Vasculitic neuropathy 2 trials
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Autoimmune neuropathy 1 trial
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Ischemic neuropathy 1 trial
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Sarcoid neuropathy 1 trial
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Motor peripheral neuropathy 0 trials · 1 incl. sub-types
9 sub-types
- Charcot-Marie-Tooth disease axonal type 2C 1 trial
- Charcot-Marie-Tooth disease type 4G 0 trials
- Charcot-Marie-Tooth disease type 5 0 trials
- Glossopharyngeal motor neuropathy 0 trials
- Hereditary motor and sensory neuropathy, Okinawa type 0 trials Sub-types →
- Motor nerve neuritis 0 trials Sub-types →
- Neuropathy, hereditary motor and sensory, type 6A 0 trials
- Neuropathy, hereditary motor and sensory, type 6B 0 trials
- Peripheral motor neuropathy, childhood-onset, biotin-responsive 0 trials
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Radiation-induced neuropathy 0 trials · 1 incl. sub-types
1 sub-type
- Radiation-induced plexopathy 1 trial
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Idiopathic small fibers neuropathy 0 trials
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Neuropathy in cryoglobulinemia 0 trials
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Neuropathy in endocrine disorder 0 trials
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Uremic neuropathy 0 trials
Most studied deeper sub-types
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New bladder cancer drug aims to fight tumors without harming nerves
Disease control Not yet recruitingThis phase II trial compares a new targeted drug, sacituzumab tirumotecan (Sac-TMT), to other antibody-drug conjugates (ADCs) in people with advanced urothelial carcinoma (bladder cancer) that has worsened after prior treatment. The main goal is to see if Sac-TMT causes less seve…
Phase 2 • Sponsor: Fudan University • Aim: Disease control
Last updated Jun 27, 2026 14:02 UTC
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New stimulation device hopes to restore limb function after brain and spinal injuries
Disease control Not yet recruitingThis study tests a new device called SSMD, which uses non-invasive stimulation to help people with movement problems after stroke, traumatic brain injury, spinal cord injury, or peripheral nerve damage. 120 adults aged 18-80 with moderate to severe arm impairment will receive eit…
Sponsor: Motion Informatics LTD • Aim: Disease control
Last updated Jun 27, 2026 09:05 UTC
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Could siliconepads replace foam to protect diabetic feet?
Disease control Not yet recruitingThis study compares two types of foot pads—siliconepads and felted foam—to see which one better reduces pressure under the ball of the foot in people with diabetes who are at high risk for foot ulcers. Researchers will measure pressure relief and ask participants about comfort an…
Sponsor: University Hospital, Ghent • Aim: Disease control
Last updated Jun 27, 2026 07:51 UTC
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Psilocybin trial aims to shield cancer patients from chemo nerve pain
Prevention Not yet recruitingThis Phase 2 trial tests whether psilocybin, a psychedelic compound, can prevent or lessen chemotherapy-induced peripheral neuropathy (nerve damage) in people with breast, colorectal, or head and neck cancer. About 83 participants will receive either psilocybin, a low-dose placeb…
Phase 2 • Sponsor: M.D. Anderson Cancer Center • Aim: Prevention
Last updated Sep 02, 2026 00:00 UTC
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Acupuncture needles aim to stop Chemo's nerve pain
Prevention Not yet recruitingThis study tests whether electroacupuncture (using mild electric pulses on needles) plus tiny thumbtack needles can prevent nerve damage caused by chemotherapy in people with early-stage cancer. About 278 patients with breast, stomach, bowel, lung, or ovarian cancer will receive …
Sponsor: Affiliated Hospital of Qinghai University • Aim: Prevention
Last updated Jun 27, 2026 14:01 UTC
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Acupuncture with a jolt: could needles shield nerves from chemo?
Prevention Not yet recruitingThis study tests whether electroacupuncture (acupuncture with mild electrical pulses) combined with tiny thumbtack needles can prevent peripheral neuropathy—numbness, tingling, or pain—caused by chemotherapy in people with advanced cancer. The trial enrolls adults with stage IV b…
Sponsor: Affiliated Hospital of Qinghai University • Aim: Prevention
Last updated Jun 27, 2026 13:06 UTC
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Glutamine supplement may shield kids from chemo nerve pain
Prevention Not yet recruitingThis study tests whether the supplement glutamine can prevent nerve damage caused by the chemotherapy drug vincristine in children and teens with cancer. About 70 participants, aged 6 to 18, will take glutamine twice daily for 14 days during their treatment. Researchers will trac…
Phase 3 • Sponsor: Ain Shams University • Aim: Prevention
Last updated Jun 27, 2026 08:04 UTC
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New device hopes to boost leg blood flow in veterans with PAD and nerve damage
Symptom relief Not yet recruitingThis study tests whether using the Replexa+ device twice daily for 3 months can improve blood flow in the lower legs and feet of veterans with peripheral artery disease (PAD) and peripheral neuropathy. Ten participants will have their blood flow measured before and after treatmen…
Sponsor: Indiana University • Aim: Symptom relief
Last updated Jun 27, 2026 13:00 UTC
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Shockwaves may soothe heel pain in neuropathy patients
Symptom relief Not yet recruitingThis study tests whether extracorporeal shockwave therapy (ESWT) can reduce pain and improve daily function in people with peripheral neuropathy who also have plantar fasciitis (heel pain). About 114 adults will receive either real or sham shockwave treatment. The goal is to see …
Phase 2 • Sponsor: National Taiwan University Hospital • Aim: Symptom relief
Last updated Jun 27, 2026 12:33 UTC
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Simple exercises may soothe chemo nerve damage
Symptom relief Not yet recruitingThis study tests whether a 15-minute hand and foot exercise routine can reduce nerve pain caused by Taxane chemotherapy in cancer patients. Fifty-eight adults with mild nerve symptoms will either do the exercises plus standard care or receive standard care alone. Researchers will…
Sponsor: University of Health Sciences Lahore • Aim: Symptom relief
Last updated Jun 27, 2026 12:29 UTC
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Could a worm enzyme soothe diabetic nerve damage?
Symptom relief Not yet recruitingThis study tests whether an oral supplement called DLBS1033 (made from earthworm proteins) can reduce nerve damage symptoms in adults with diabetic polyneuropathy. Thirty-four people with type 2 diabetes will receive either the supplement or a placebo for 28 days, alongside stand…
Phase 2/3 • Sponsor: Universitas Sebelas Maret • Aim: Symptom relief
Last updated Jun 27, 2026 11:01 UTC
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Can pressurized oxygen soothe chemo nerve pain?
Symptom relief Not yet recruitingThis study tests whether hyperbaric oxygen therapy—breathing pure oxygen in a pressurized chamber—can reduce nerve pain and numbness caused by the chemotherapy drug nab-paclitaxel in breast cancer patients. About 160 women who have finished chemo and developed nerve symptoms will…
Phase 2/3 • Sponsor: Guangdong Provincial People's Hospital • Aim: Symptom relief
Last updated Jun 27, 2026 09:04 UTC
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Simple hand and foot moves may ease chemo nerve pain in older cancer patients
Symptom relief Not yet recruitingThis study looks at whether hand and foot exercises can reduce nerve pain (numbness, tingling) and improve quality of life in adults aged 65+ with gynecological cancer who are on chemotherapy. About 74 participants will do these exercises to see if they help with chemotherapy sid…
Sponsor: Taipei Veterans General Hospital, Taiwan • Aim: Symptom relief
Last updated Jun 27, 2026 08:13 UTC
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New study tests diet and massage combo for diabetic nerve pain
Symptom relief Not yet recruitingThis study will test three approaches to reduce painful nerve damage in people with type 2 diabetes. Sixty adults aged 35-85 with moderate to severe neuropathy will receive either a special massage-like therapy (INF), a diet guided by a food sensitivity test (NVIf), or both toget…
Sponsor: Loma Linda University • Aim: Symptom relief
Last updated Jun 27, 2026 07:54 UTC
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Exercise program aims to ease breast cancer side effects
Symptom relief Not yet recruitingThis study tests a 3-month exercise program for women with breast cancer who have arm swelling (lymphedema) and nerve pain (neuropathy) from treatment. Thirty women will do general and arm-specific exercises twice a week. Researchers will measure changes in arm size and pain leve…
Sponsor: Universitat Internacional de Catalunya • Aim: Symptom relief
Last updated Jun 26, 2026 18:29 UTC
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Wrist artery procedure: is nerve damage a hidden risk?
Knowledge-focused Not yet recruitingThis study will check if doing a heart procedure through the wrist artery can hurt nearby nerves. About 100 adults will get nerve tests before and after the procedure. The goal is to find out how often nerve injury happens and how serious it is.
Sponsor: Bursa City Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:01 UTC