Overgrowth syndrome
MONDO:0019716A group of syndromes caused by genetic birth defects that may lead to the development of malignancies. It is characterized by a large body size or large body parts at birth, or excessive body growth early in childhood. Representative examples include neurofibromatosis, Beckwith-Wiedemann syndrome, and Sturge-Weber syndrome.
49 clinical trials for this condition and its sub-types, 1 tagged with Overgrowth syndrome itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Sub-types of Overgrowth syndrome
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PIK3CA-related overgrowth spectrum 15 trials · 19 incl. sub-types
5 sub-types
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Simpson-Golabi-Behmel syndrome 11 trials
2 sub-types
- Simpson-Golabi-Behmel syndrome type 1 0 trials
- Simpson-Golabi-Behmel syndrome type 2 0 trials
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Beckwith-Wiedemann syndrome 6 trials
8 sub-types
- Beckwith-Wiedemann syndrome due to 11p15 microdeletion 0 trials
- Beckwith-Wiedemann syndrome due to 11p15 microduplication 0 trials
- Beckwith-Wiedemann syndrome due to 11p15 translocation/inversion 0 trials
- Beckwith-Wiedemann syndrome due to CDKN1C mutation 0 trials
- Beckwith-Wiedemann syndrome due to NSD1 mutation 0 trials
- Beckwith-Wiedemann syndrome due to imprinting defect of 11p15 0 trials
- Beckwith-Wiedemann syndrome due to paternal uniparental disomy of chromosome 11 0 trials
- Franceschini Vardeu Guala syndrome 0 trials
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Angioosteohypertrophic syndrome 6 trials
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Hemifacial hypertrophy 5 trials
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Maffucci syndrome 2 trials
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Proteus syndrome 2 trials
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Congenital isolated hyperinsulinism 0 trials · 2 incl. sub-types
4 sub-types
- Diazoxide-sensitive diffuse hyperinsulinism 0 trials · 2 incl. sub-types Sub-types →
- Hyperinsulinemic hypoglycemia, familial, 2 1 trial Sub-types →
- Diazoxide-resistant hyperinsulinism 0 trials Sub-types →
- Hyperinsulinemic hypoglycemia, familial, 3 0 trials
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11p15.4 microduplication syndrome 0 trials
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15q overgrowth syndrome 0 trials
2 sub-types
- Distal tetrasomy 15q 0 trials
- Distal trisomy 15q 0 trials
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4p16.3 microduplication syndrome 0 trials
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AKT3-related overgrowth spectrum 0 trials
1 sub-type
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CLAPO syndrome 0 trials
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MTOR-related overgrowth spectrum 0 trials
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Malan overgrowth syndrome 0 trials
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Marshall-Smith syndrome 0 trials
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PIK3R2-related overgrowth spectrum 0 trials
1 sub-type
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Perlman syndrome 0 trials
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Weaver syndrome 0 trials
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Hemifacial myohyperplasia 0 trials
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Isolated hemihyperplasia 0 trials
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Tetrasomy 12p 0 trials
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Trisomy 5p 0 trials
Most studied deeper sub-types
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New hope for kids with rare kidney cancer: chemo first, then surgery to save kidneys
Disease control CompletedThis study tested giving chemotherapy before surgery to children with Wilms tumor, a rare kidney cancer. The goal was to shrink tumors so surgeons could remove less kidney tissue, helping preserve kidney function. 249 children took part, and the approach aimed to reduce the need …
Phase 3 • Sponsor: Children's Oncology Group • Aim: Disease control
Last updated Jun 27, 2026 13:01 UTC
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Could a drug stop uncontrolled body growth? small study tests sirolimus
Disease control CompletedThis pilot study tested the drug sirolimus in 16 people aged 3 to 65 who have excessive growth in parts of their body due to a change in the PIK3CA gene. The goal was to see if sirolimus can stop or slow that overgrowth. Researchers used MRI scans and other measures to track chan…
Phase 2 • Sponsor: Centre Hospitalier Universitaire Dijon • Aim: Disease control
Last updated Jun 27, 2026 07:58 UTC
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Can 3D photos reveal who needs surgery for facial asymmetry?
Diagnosis CompletedResearchers are testing whether 3D photographs can accurately measure facial asymmetry in adults aged 18 to 40 who have no craniofacial deformities. The study uses stereophotogrammetry to create a 3D image and then calculates an asymmetry index to classify faces as symmetric, sli…
Sponsor: Fondazione Policlinico Universitario Agostino Gemelli IRCCS • Aim: Diagnosis
Last updated Sep 10, 2026 00:00 UTC
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New drug may ease severe skin rashes in cancer patients
Symptom relief CompletedThis study tested whether the drug benralizumab can safely reduce skin rashes caused by cancer treatments like checkpoint inhibitors. The goal was to lower the number of high-grade rashes to milder ones, which could improve quality of life and help patients stay on their cancer t…
Phase 2 • Sponsor: Memorial Sloan Kettering Cancer Center • Aim: Symptom relief
Last updated Jun 27, 2026 13:01 UTC
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New registry sheds light on rare overgrowth diseases
Knowledge-focused CompletedThis completed study created a French national registry for people with rare overgrowth syndromes caused by PIK3CA gene mutations. Researchers collected medical and genetic information from 28 patients to better understand these conditions and estimate how many people are affecte…
Sponsor: Institut National de la Santé Et de la Recherche Médicale, France • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:07 UTC
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French study tracks port wine stains in kids to uncover hidden risks
Knowledge-focused CompletedThis study followed 150 children aged 2 to 12 who have a port wine stain on a leg. Researchers tracked how the stain changes as the child grows, and whether it leads to problems like blood vessel issues or bone growth differences. The goal was to learn more about the condition an…
Sponsor: University Hospital, Tours • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:06 UTC
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Could a brief nerve squeeze improve lung surgery recovery?
Knowledge-focused CompletedThis study looked at whether briefly pressing on the phrenic nerve during lung surgery could help reduce complications like air leaks. Researchers compared 55 patients who had this temporary nerve compression with those who did not. They measured diaphragm activity, lung function…
Sponsor: Ferdane Melike Duran • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:00 UTC
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French hospital data reveals hidden burden of rare PROS disorders
Knowledge-focused CompletedThis study looked at hospital records from 2015 to 2022 to find out how many people in France have a group of rare genetic conditions called PROS. Researchers counted new cases each year, described patient ages and other health problems, and estimated costs. No treatments were te…
Sponsor: Novartis Pharmaceuticals • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:56 UTC