Opportunistic mycosis

This study tests two new ways to treat talaromycosis, a serious fungal infection in people with HIV. It compares a single high dose of a newer antifungal drug (liposomal amphotericin B) against two weeks of the standard drug, and also checks if adding another medicine (flucytosin…

Researchers are studying depemokimab, an injected biologic drug, in adults aged 18 to 75 who have allergic bronchopulmonary aspergillosis (ABPA) along with severe eosinophilic asthma. The study tracks how many asthma attacks need systemic steroids and whether participants' qualit…

Researchers compare two oral antifungal medicines, itraconazole and posaconazole, in people with chronic pulmonary aspergillosis, a fungal infection that damages the lungs over time. The trial enrolls 220 adults who have not yet received antifungal treatment and assigns them to o…

This trial is testing whether a 10-week course of fluconazole works as well as the standard 24-week course for people with HIV who have a cryptococcal infection in their blood (antigenemia) but no symptoms. It also compares starting HIV medications right away versus waiting 14 da…

This trial investigates whether a shorter course of the antifungal drug caspofungin is as effective as the standard 14-day treatment for uncomplicated candidemia, a bloodstream infection caused by Candida yeast. Adults with this infection will be randomly assigned to receive eith…

This study tests whether a light-activated treatment called Rose Bengal photodynamic therapy can help people with a severe fungal eye infection called Fusarium keratitis. The infection can cause vision loss, and standard treatments may not always work. Participants receive either…

This study is testing whether tezepelumab, an injectable medication, can help people with severe asthma caused by allergic bronchopulmonary aspergillosis (ABPA), a condition where the immune system overreacts to certain fungi. The trial will enroll 10 adults aged 18 to 75 who hav…

Invasive mold infections are a major threat to liver transplant recipients, with mortality rates as high as 90%. The standard treatment, voriconazole, can interfere with anti-rejection drugs, increasing the risk of graft loss. This trial tests whether liposomal amphotericin B (Am…

This trial tests whether adding a clinical pharmacist to dental care can improve how oral mucosal disorders — such as oral lichen planus, recurrent canker sores, burning mouth syndrome, oral thrush, and herpes infections — are managed. Dentists in some clinics will get pharmacist…

This study looks at whether a lower dose of the antibiotic TMP-SMX works as well as the standard dose for treating a serious lung infection called Pneumocystis pneumonia (PCP) in people who do not have HIV. The standard dose often causes side effects in more than half of patients…

This study tests whether a vaginal ovule device, used alongside standard antibiotics or antifungals, improves vaginal health in women with bacterial vaginosis or yeast infections. Eighty women aged 18 to 60 receive either the active device or a placebo ovule over three treatment …

This study tests whether blue LED light therapy can improve symptoms of common vaginal conditions like menopause-related dryness, bacterial vaginosis, and yeast infections. About 150 women aged 18 to 75 will receive the treatment either at home or in a clinic. Researchers will ch…

This study tests a drug called Sintilimab, which is normally used for cancer, to see if it can help people with HIV who have infections that won't go away with standard treatment. The drug works by 'waking up' exhausted immune cells. Fifty adults with HIV and a hard-to-treat infe…

This study looks at which second-choice treatment works best for a serious lung infection called PCP when the usual antibiotic cannot be used due to allergies, side effects, or failure. About 416 adults with weakened immune systems (from HIV, transplants, cancer, or other causes)…

This study tests a drug called liposomal amphotericin B in 40 ICU patients who have a severe fungal infection (invasive aspergillosis) and liver problems. The drug is given daily for 2 weeks, followed by 4 weeks of monitoring. The goal is to see if it is safe and effective for th…

This study looks at how long steroids should be given to adults with severe Pneumocystis pneumonia (PCP), a serious lung infection common in people with weakened immune systems. About 416 participants who improve within 10 days will either stop steroids early or continue for 21 d…

This study tests whether adding corticosteroids (low or moderate dose) to standard care can reduce deaths from severe Pneumocystis pneumonia (PJP) in non-HIV patients in the ICU. PJP has a very high death rate of 60-80% in this group. The trial will compare two steroid doses agai…

This trial tests whether low or moderate doses of the steroid methylprednisolone can reduce deaths in patients with severe community-acquired pneumonia. It will enroll 1500 ICU patients with pneumonia caused by adenovirus or Pneumocystis jirovecii. The study uses an adaptive desi…

This study tests whether a lower dose of the antibiotic TMP-SMX works as well as the standard dose to prevent a serious lung infection called PJP in people who have just had a kidney transplant. About 1,084 adult first-time kidney transplant recipients will take either a low or s…

This study tests whether a short course of the steroid prednisolone can prevent paradoxical immune reconstitution inflammatory syndrome (IRIS) in people with AIDS who have low CD4 counts and are starting HIV treatment. About 131 participants will receive either prednisolone or no…

This study tests a medical device called Rephegyn vaginal ovules to help treat fungal (candidiasis) and bacterial infections. The device is designed to help heal the vaginal lining and reduce symptoms like discharge, pain, and itching. About 34 adults with recurrent infections wi…

This study looks at how well an inhaled antifungal drug (liposomal amphotericin B) reaches the lungs in people with chronic pulmonary aspergillosis, a long-term lung infection. About 18 adults will inhale two different doses on separate days and then have special scans to see whe…

This study will analyze respiratory samples from 1,000 patients in France to understand why some Aspergillus fungi become resistant to common antifungal drugs. Researchers will test samples for resistance and collect information about patients' environments, jobs, and medication …

This study aims to find the best dose of isavuconazole, an antifungal drug, for patients over 60 with invasive fungal infections. Researchers will monitor drug levels in the blood and adjust doses to improve treatment and reduce side effects. The goal is to create personalized do…

This study will look at Candida fungi from 300 patients in a hematology ICU. Researchers want to see how often these fungi form biofilms (slimy layers that protect them) and whether that makes them resistant to antifungal drugs. The goal is to learn which Candida types are most c…