Obesity due to leptin receptor gene deficiency

This study looks at whether improving sleep habits can help teenagers with overweight or obesity better regulate blood sugar and energy. Researchers will enroll 60 teens aged 14-19 who get less than 7 hours of sleep on school nights. For two weeks, participants will follow a slee…

This study looks at whether giving people feedback on their metabolic profile (blood test results) halfway through a 3-month low-starch, low-sugar diet helps them lose more weight. 300 overweight adults (BMI over 25) will follow the diet, and half will learn their metabolic impro…

This early-stage study tests an experimental drug called CMS-D008 in 110 healthy and overweight or obese adults. The main goal is to check safety and how the body processes the drug, not weight loss. Participants will receive either the drug or a placebo as injections, and resear…

This study will compare two ultrasound-guided nerve blocks—the external oblique intercostal plane block and the subcostal transversus abdominis plane block—for controlling pain after laparoscopic sleeve gastrectomy. Ninety adults aged 18–65 will receive one of the blocks plus sta…

This study will compare two devices that blow gas into the belly during laparoscopic sleeve gastrectomy (a weight-loss surgery). The goal is to see if one device causes less pain after surgery than the other. About 74 adults aged 22 to 65 having planned sleeve gastrectomy will be…

This study looks at how having extra body fat and being resistant to insulin can change the way your brain learns to like or want certain foods. Researchers will give 50 adults flavored drinks with sweetener, sometimes with extra calories, to see how their preferences shift. The …

This study looks at how two common medications, rosuvastatin (a cholesterol drug) and losartan (a blood pressure drug), are absorbed in people who have had weight-loss surgery. Sixty adults scheduled for either Roux-en-Y gastric bypass or sleeve gastrectomy will take a single dos…

This study looks at how different types of obesity—central (belly fat) versus peripheral (fat elsewhere)—affect blood loss and complications during major lower back surgery. Researchers will measure pressure inside the abdomen and blood loss in 90 adults having lumbar spine surge…

This pilot study tests whether patients having laparoscopic gastric bypass can safely go home the same day if they use a remote monitoring device. Forty adults will be randomly assigned to either same-day discharge with remote monitoring or an overnight hospital stay. The study w…

This study watches how body fat and muscle affect the way anesthetic drugs work in overweight and obese patients. Researchers will measure body composition and drug levels in 2,100 adults during surgery. The goal is to understand why heavier patients may have more complications, …

This observational study will examine how posture habits and body awareness relate to physical function in 80 women aged 18-65 across different BMI categories (normal weight to obesity). Participants will fill out questionnaires and perform simple movement tests. The goal is to u…

This study watches how carbon dioxide gas, used to inflate the belly during laparoscopic weight-loss surgery, changes blood bicarbonate levels. Researchers will track 85 adults having sleeve gastrectomy or gastric bypass to see if these changes relate to how long the gas is used …