Neurotrophic keratopathy
MONDO:0015290Neurotrophic keratopathy is a rare degenerative disease of the cornea characterized by reduction or loss of corneal sensitivity that can be asymptomatic or present with red-eye and, during the early stages of the disease, a minor decrease in visual acuity. It eventually leads to loss of vision.
Also known as: neurotrophic keratitis
17 clinical trials for this condition and its sub-types, 17 tagged with Neurotrophic keratopathy itself.
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New eye drops show promise for healing corneal damage
Disease control CompletedThis study tested an experimental eye drop called CSB-001 in 131 people with neurotrophic keratitis, a rare condition where the cornea loses sensation and can develop ulcers. Participants used the drops four times daily for 8 weeks. The goal was to see if the drops could fully he…
Phase 1/2 • Sponsor: Claris Biotherapeutics, Inc. • Aim: Disease control
Last updated Jun 27, 2026 12:34 UTC
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New eye drop shows promise for rare corneal disease
Disease control CompletedThis early-stage trial tested an experimental eye drop called STSP-0902 in 82 healthy volunteers to see if it is safe and how the body processes it. The study involved single and multiple doses, with some participants getting a placebo. The goal is to eventually treat neurotrophi…
Phase 1 • Sponsor: Staidson (Beijing) Biopharmaceuticals Co., Ltd • Aim: Disease control
Last updated Jun 27, 2026 12:06 UTC
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OXERVATE eye drops show promise for Long-Term corneal healing in rare eye disease
Disease control CompletedThis study followed 24 people with stage 1 neurotrophic keratitis, a rare eye condition that can damage the cornea, who had previously used OXERVATE eye drops in an earlier study. Researchers checked if the cornea stayed healed up to 30 months after treatment. The goal was to see…
Sponsor: Dompé Farmaceutici S.p.A • Aim: Disease control
Last updated Jun 27, 2026 08:00 UTC
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New eye drop shows promise for rare corneal disease
Disease control CompletedThis study tested an eye drop called OXERVATE in 37 adults with stage 1 neurotrophic keratitis, a condition where the cornea loses feeling and doesn't heal properly. The treatment was given for 8 weeks, and patients were followed for 24 weeks to see if the cornea healed safely. T…
Phase 4 • Sponsor: Dompé Farmaceutici S.p.A • Aim: Disease control
Last updated Jun 27, 2026 07:57 UTC
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Simple eye test could predict nerve damage in dry eye sufferers
Knowledge-focused CompletedThis completed study looked at 31 people with dry eye to see if measuring corneal sensitivity (how well the eye feels touch) can detect early-stage neurotrophic keratopathy, a condition where the cornea loses sensation. Researchers aimed to find out which dry eye patients might l…
Sponsor: Research Insight LLC • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:01 UTC