Neurodevelopmental disorder
MONDO:0700092A behavioral and cognitive disorder with onset during the developmental period that involves impaired or aberrant development of intellectual, motor, or social functions.
1128 clinical trials for this condition and its sub-types, 161 tagged with Neurodevelopmental disorder itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Sub-types of Neurodevelopmental disorder
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Complex neurodevelopmental disorder 3 trials · 871 incl. sub-types
15 sub-types
- Pervasive developmental disorder 21 trials · 737 incl. sub-types Sub-types →
- Developmental and epileptic encephalopathy 29 trials · 98 incl. sub-types Sub-types →
- Prader-Willi syndrome 31 trials Sub-types →
- Complex neurodevelopmental disorder with motor features 1 trial · 10 incl. sub-types Sub-types →
- GRIN-related complex neurodevelopmental disorder 2 trials Sub-types →
- AFG2B-related complex neurodevelopmental disorder with motor features and hearing loss 0 trials
- DEAF1-associated neurodevelopmental disorder 0 trials Sub-types →
- NACC1-related neurodevelopmental disorder with epilepsy, cataracts and episodic irritability 0 trials
- X-linked complex neurodevelopmental disorder 0 trials Sub-types →
- Complex neurodevelopmental disorder with or without congenital anomalies 0 trials Sub-types →
- Intellectual disability, autosomal dominant 29 0 trials
- Neonatal encephalopathy with non-epileptic myoclonus 0 trials
- Neurodevelopmental disorder with language impairment and behavioral abnormalities 0 trials
- Neurodevelopmental disorder with severe motor impairment and absent language 0 trials
- Syndromic complex neurodevelopmental disorder 0 trials Sub-types →
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Mendelian neurodevelopmental disorder 0 trials · 207 incl. sub-types
275 sub-types
- Genetic developmental and epileptic encephalopathy 2 trials · 83 incl. sub-types Sub-types →
- Prader-Willi syndrome 31 trials Sub-types →
- Rett syndrome 31 trials
- Intellectual disability, autosomal dominant 0 trials · 23 incl. sub-types Sub-types →
- X-linked intellectual disability 1 trial · 15 incl. sub-types Sub-types →
- CACNA1A-related complex neurodevelopmental disorder 1 trial · 9 incl. sub-types Sub-types →
- Autosomal recessive primary microcephaly 0 trials · 8 incl. sub-types Sub-types →
- Smith-Magenis syndrome 5 trials
- Rubinstein-Taybi syndrome 3 trials Sub-types →
- Alternating hemiplegia of childhood 3 trials Sub-types →
- FOXG1 disorder 2 trials
- GRIN-related complex neurodevelopmental disorder 2 trials Sub-types →
- Neurodevelopmental disorder with involuntary movements 2 trials
- CAMK2D-related neurodevelopmental disorder and dilated cardiomyopathy 1 trial
- Dyneinopathy 0 trials · 1 incl. sub-types Sub-types →
- Intellectual disability, autosomal recessive 0 trials · 1 incl. sub-types Sub-types →
- Microcephalic osteodysplastic primordial dwarfism type I 1 trial
- Microcephalic osteodysplastic primordial dwarfism type II 1 trial
- Neurodevelopmental disorder with cerebellar atrophy and motor dysfunction 1 trial
- Neurodevelopmental disorder with or without variable brain abnormalities; NEDBA 1 trial
- Orofaciodigital syndrome I 1 trial
- AFG2B-related complex neurodevelopmental disorder with motor features and hearing loss 0 trials
- AHDC1-related intellectual disability - obstructive sleep apnea - mild dysmorphism syndrome 0 trials
- ARF3-related neurodevelopmental disorder 0 trials
- ATXN7L3-related developmental delay, hypotonia and facial dysmorphism 0 trials
- Alzahrani-Kuwahara syndrome 0 trials
- Amish lethal microcephaly 0 trials
- Au-Kline syndrome 0 trials
- Brunet-Wagner neurodevelopmental syndrome 0 trials
- CBX1-related neurodevelopmental disorder 0 trials
- CK syndrome 0 trials
- CNOT9-related developmental disorder with seizures 0 trials
- CTR9-related neurodevelopmental disorder 0 trials
- Chilton-Okur-Chung neurodevelopmental syndrome 0 trials
- DDX17-related neurodevelopmental disorder 0 trials
- DEAF1-associated neurodevelopmental disorder 0 trials Sub-types →
- DIP2C-related developmental disorder with speech delay 0 trials
- Delpire-McNeill syndrome 0 trials
- Dentici-Novelli neurodevelopmental syndrome 0 trials
- Dursun-Ozgul neurodevelopmental syndrome 0 trials
- Dworschak-Punetha neurodevelopmental syndrome 0 trials
- EPB41L3-related developmental disorder with delayed myelination and seizures 0 trials
- El Hayek-Chahrour neurodevelopmental disorder 0 trials
- FAT4-related neurodevelopmental disorder 0 trials
- FEZF2-related neurodevelopmental disorder 0 trials
- Ferguson-Bonni neurodevelopmental syndrome 0 trials
- GABRA4-related neurodevelopmental disorder with seizures 0 trials
- GABRD-related neurodevelopmental disorder with epilepsy 0 trials
- HDAC3-related neurodevelopmental disorder 0 trials
- HMGB1-related brachyphalangy, polydactyly and tibial aplasia syndrome 0 trials
- HNRNPC-related neurodevelopmental disorder 0 trials Sub-types →
- Hao-Fountain syndrome due to USP7 mutation 0 trials
- Harel-Tora neurodevelopmental syndrome 0 trials
- Harel-Yoon syndrome 0 trials
- Hiatt-Neu-Cooper neurodevelopmental syndrome 0 trials
- Houge-Janssens syndrome 3 0 trials
- Jeffries-Lakhani neurodevelopmental syndrome 0 trials
- KCND2-related neurodevelopmental disorder with or without seizures 0 trials
- KCNH1 associated disorder 0 trials Sub-types →
- KCNK3-related developmental delay with sleep apnea 0 trials
- KDM2B-related neurodevelopmental disorder 0 trials
- Karayol-Borroto-Haghshenas neurodevelopmental syndrome 0 trials
- Kariminejad neurodevelopmental syndrome 0 trials
- Li-Takada-Miyake syndrome 0 trials
- MYCBP2-related developmental delay with corpus callosum defects 0 trials
- MYH10-related neurodevelopmental disorder with congenital anomalies 0 trials
- Marbach-Schaaf neurodevelopmental syndrome 0 trials
- NACC1-related neurodevelopmental disorder with epilepsy, cataracts and episodic irritability 0 trials
- Nil-Deshwar neurodevelopmental syndrome 0 trials
- Okur-Chung neurodevelopmental syndrome 0 trials
- PAX5-related B lymphopenia and autism spectrum disorder 0 trials
- PIP5K1C-related neurodevelopmental disorder 0 trials
- PPFIA3-related neurodevelopmental disorder 0 trials
- PPP2R1A-related intellectual disability 0 trials
- PRPF19-related neurodevelopmental disorder 0 trials
- Pitt-Hopkins-like syndrome 2 0 trials
- Poirier-Bienvenu neurodevelopmental syndrome 0 trials
- Popov-Chang syndrome 0 trials
- RFX3-related neurodevelopmental disorder with autism and other behavioural abnormalities 0 trials
- RFX4-related neurodevelopmental disorder with autism and other behavioural abnormalities 0 trials
- RNU5B-1 related neurodevelopmental disorder with seizures and joint laxity 0 trials
- Ramond-Elliott neurodevelopmental syndrome 0 trials
- SETD2-related neurodevelopmental disorder without or with macrocephaly/overgrowth 0 trials Sub-types →
- SOX11-related complex neurodevelopmental disorder with or without congenital anomalies 0 trials
- SYNCRIP-related neurodevelopmental disorder 0 trials
- Stankiewicz-Isidor syndrome 0 trials
- TRA2B-related neurodevelopmental disorder 0 trials
- WDR5-related neurodevelopmental disorder 0 trials
- Wieacker-Wolff syndrome 0 trials
- X-linked complex neurodevelopmental disorder 0 trials Sub-types →
- Aplasia cutis-enamel dysplasia syndrome 0 trials
- Autosomal dominant primary microcephaly 0 trials Sub-types →
- Cerebellar atrophy, visual impairment, and psychomotor retardation; 0 trials
- Cerebral palsy, spastic quadriplegic, 2 0 trials
- Cerebral palsy, spastic quadriplegic, 3 0 trials
- Complex cortical dysplasia with other brain malformations 5 0 trials
- Developmental delay and seizures with or without movement abnormalities 0 trials
- Developmental delay with autism spectrum disorder and gait instability 0 trials
- Developmental delay with variable intellectual impairment and behavioral abnormalities 0 trials
- Encephalopathy, neonatal severe, with lactic acidosis and brain abnormalities 0 trials
- Intellectual developmental disorder and retinitis pigmentosa; IDDRP 0 trials
- Intellectual developmental disorder with polymicrogyria and seizures 0 trials
- Intellectual disability, autosomal dominant 29 0 trials
- Microcephalic osteodysplastic primordial dwarfism, type 3 0 trials
- Microcephaly and chorioretinopathy 0 trials Sub-types →
- Microcephaly with lissencephaly and/or hydranencephaly 0 trials Sub-types →
- Microcephaly with or without chorioretinopathy, lymphedema, or intellectual disability 0 trials
- Microcephaly, progressive, with simplified gyral pattern and cerebellar hypoplasia 0 trials
- Neurocardiorenal malformation syndrome 0 trials
- Neurodevelopmental disorder and structural brain anomalies with or without seizures and spasticity 0 trials
- Neurodevelopmental disorder plus optic atrophy 0 trials
- Neurodevelopmental disorder with absent language and variable seizures 0 trials
- Neurodevelopmental disorder with absent speech and movement and behavioral abnormalities 0 trials
- Neurodevelopmental disorder with achalasia, polyneuropathy, and alacrima 0 trials
- Neurodevelopmental disorder with alopecia and brain abnormalities 0 trials
- Neurodevelopmental disorder with ataxia and brain abnormalities 0 trials
- Neurodevelopmental disorder with ataxia, hypotonia, and microcephaly 0 trials
- Neurodevelopmental disorder with ataxic gait, absent speech, and decreased cortical white matter 0 trials
- Neurodevelopmental disorder with behavioral abnormalities and childhood-onset spastic paraplegia 0 trials
- Neurodevelopmental disorder with behavioral abnormalities, absent speech, and hypotonia 0 trials
- Neurodevelopmental disorder with behavioral, ear, and skeletal abnormalities 0 trials
- Neurodevelopmental disorder with brain anomalies and with or without vertebral or cardiac anomalies 0 trials
- Neurodevelopmental disorder with cardiomyopathy, spasticity, and brain abnormalities 0 trials
- Neurodevelopmental disorder with cataracts, poor growth, and dysmorphic facies 0 trials
- Neurodevelopmental disorder with central and peripheral motor dysfunction 0 trials
- Neurodevelopmental disorder with central hypotonia and dysmorphic facies 0 trials Sub-types →
- Neurodevelopmental disorder with cerebellar atrophy and with or without seizures 0 trials
- Neurodevelopmental disorder with cerebellar hypoplasia and spasticity 0 trials
- Neurodevelopmental disorder with cerebral atrophy and variable facial dysmorphism 0 trials
- Neurodevelopmental disorder with characteristic facial and ectodermal features and tetraparesis 1 0 trials
- Neurodevelopmental disorder with coarse facies and mild distal skeletal abnormalities 0 trials
- Neurodevelopmental disorder with congenital cardiac defects and variable renal and ocular abnormalities 0 trials
- Neurodevelopmental disorder with craniofacial dysmorphism and skeletal defects 0 trials
- Neurodevelopmental disorder with dysmorphic facies and behavioral abnormalities 0 trials
- Neurodevelopmental disorder with dysmorphic facies and cerebellar hypoplasia 0 trials
- Neurodevelopmental disorder with dysmorphic facies and distal limb anomalies 0 trials
- Neurodevelopmental disorder with dysmorphic facies and distal skeletal anomalies 0 trials
- Neurodevelopmental disorder with dysmorphic facies and ischiopubic hypoplasia 0 trials
- Neurodevelopmental disorder with dysmorphic facies and skeletal and brain abnormalities 0 trials
- Neurodevelopmental disorder with dysmorphic facies and thin corpus callosum 0 trials
- Neurodevelopmental disorder with dysmorphic facies and variable seizures 0 trials
- Neurodevelopmental disorder with dysmorphic facies, absent speech and ambulation, and brain abnormalities 0 trials
- Neurodevelopmental disorder with dysmorphic facies, brain anomalies, and seizures 0 trials
- Neurodevelopmental disorder with dysmorphic facies, impaired speech, and hypotonia 0 trials
- Neurodevelopmental disorder with dysmorphic facies, sleep disturbance, and brain abnormalities 0 trials
- Neurodevelopmental disorder with dystonia and seizures 0 trials
- Neurodevelopmental disorder with early-onset parkinsonism and behavioral abnormalities 0 trials
- Neurodevelopmental disorder with early-onset seizures, facial dysmorphism, and behavioral abnormalities 0 trials
- Neurodevelopmental disorder with epilepsy and brain atrophy 0 trials
- Neurodevelopmental disorder with epilepsy and hypoplasia of the corpus callosum 0 trials
- Neurodevelopmental disorder with epilepsy, cataracts, feeding difficulties, and delayed brain myelination 0 trials
- Neurodevelopmental disorder with epilepsy, spasticity, and brain atrophy 0 trials
- Neurodevelopmental disorder with eye movement abnormalities and ataxia 0 trials
- Neurodevelopmental disorder with facial dysmorphism, absent language, and pseudo-pelger-huet anomaly 0 trials
- Neurodevelopmental disorder with gait disturbance, dysmorphic facies, and behavioral abnormalities, X-linked 0 trials
- Neurodevelopmental disorder with growth impairment, quadriparesis, and poor or absent speech 0 trials
- Neurodevelopmental disorder with growth retardation, dysmorphic facies, and corpus callosum abnormalities 0 trials
- Neurodevelopmental disorder with hearing loss and spasticity 0 trials
- Neurodevelopmental disorder with hyperkinetic movements and dyskinesia 0 trials
- Neurodevelopmental disorder with hyperkinetic movements, seizures, and structural brain abnormalities 0 trials
- Neurodevelopmental disorder with hypotonia and autistic features with or without hyperkinetic movements 0 trials
- Neurodevelopmental disorder with hypotonia and brain abnormalities 0 trials
- Neurodevelopmental disorder with hypotonia and cerebellar atrophy, with or without seizures 0 trials
- Neurodevelopmental disorder with hypotonia and characteristic brain abnormalities 0 trials
- Neurodevelopmental disorder with hypotonia and dysmorphic facies 0 trials
- Neurodevelopmental disorder with hypotonia and gross motor and speech delay 0 trials
- Neurodevelopmental disorder with hypotonia and seizures 0 trials
- Neurodevelopmental disorder with hypotonia and speech delay, with or without seizures 0 trials
- Neurodevelopmental disorder with hypotonia and variable intellectual and behavioral abnormalities 0 trials
- Neurodevelopmental disorder with hypotonia, brain anomalies, distinctive facies, and absent language 0 trials
- Neurodevelopmental disorder with hypotonia, dysmorphic facies, and skeletal anomalies, with or without seizures 0 trials
- Neurodevelopmental disorder with hypotonia, dysmorphic facies, and skin abnormalities 0 trials
- Neurodevelopmental disorder with hypotonia, epilepsy, and absent speech 0 trials
- Neurodevelopmental disorder with hypotonia, facial dysmorphism, and brain abnormalities 0 trials
- Neurodevelopmental disorder with hypotonia, feeding difficulties, facial dysmorphism, and brain abnormalities 0 trials
- Neurodevelopmental disorder with hypotonia, impaired speech, and behavioral abnormalities 0 trials
- Neurodevelopmental disorder with hypotonia, language delay, and skeletal defects with or without seizures 0 trials
- Neurodevelopmental disorder with hypotonia, microcephaly, and seizures 0 trials
- Neurodevelopmental disorder with hypotonia, neonatal respiratory insufficiency, and thermodysregulation 0 trials
- Neurodevelopmental disorder with hypotonia, neuropathy, and deafness 0 trials
- Neurodevelopmental disorder with hypotonia, poor growth, dysmorphic facies, and agammaglobulinemia 0 trials
- Neurodevelopmental disorder with hypotonia, seizures, and absent language 0 trials
- Neurodevelopmental disorder with impaired intellectual development, hypotonia, and ataxia 0 trials
- Neurodevelopmental disorder with impaired language and ataxia and with or without seizures 0 trials
- Neurodevelopmental disorder with impaired language, behavioral abnormalities, and dysmorphic facies 0 trials
- Neurodevelopmental disorder with impaired speech and hyperkinetic movements 0 trials
- Neurodevelopmental disorder with infantile epileptic spasms 0 trials
- Neurodevelopmental disorder with intention tremor, pyramidal signs, dyspraxia, and ocular anomalies 0 trials
- Neurodevelopmental disorder with intracranial hemorrhage, seizures, and spasticity 0 trials
- Neurodevelopmental disorder with language delay and behavioral abnormalities, with or without seizures 0 trials
- Neurodevelopmental disorder with language delay and seizures 0 trials
- Neurodevelopmental disorder with language delay and variable cognitive abnormalities 0 trials
- Neurodevelopmental disorder with language impairment and behavioral abnormalities 0 trials
- Neurodevelopmental disorder with language impairment, autism, and attention deficit-hyperactivity disorder 0 trials
- Neurodevelopmental disorder with microcephaly and dysmorphic facies 0 trials
- Neurodevelopmental disorder with microcephaly and movement abnormalities 0 trials
- Neurodevelopmental disorder with microcephaly and speech delay, with or without brain abnormalities 0 trials
- Neurodevelopmental disorder with microcephaly and structural brain anomalies 0 trials
- Neurodevelopmental disorder with microcephaly, absent speech, and hypotonia 0 trials
- Neurodevelopmental disorder with microcephaly, arthrogryposis, and structural brain anomalies 0 trials
- Neurodevelopmental disorder with microcephaly, ataxia, and seizures 0 trials
- Neurodevelopmental disorder with microcephaly, cataracts, and renal abnormalities 0 trials
- Neurodevelopmental disorder with microcephaly, cerebral atrophy, and visual impairment 0 trials
- Neurodevelopmental disorder with microcephaly, cortical malformations, and spasticity 0 trials
- Neurodevelopmental disorder with microcephaly, epilepsy, and brain atrophy 0 trials
- Neurodevelopmental disorder with microcephaly, epilepsy, and hypomyelination 0 trials
- Neurodevelopmental disorder with microcephaly, hypotonia, and variable brain anomalies 0 trials
- Neurodevelopmental disorder with microcephaly, hypotonia, nystagmus, and seizures 0 trials
- Neurodevelopmental disorder with microcephaly, impaired language, and gait abnormalities 0 trials
- Neurodevelopmental disorder with microcephaly, impaired language, epilepsy, and gait abnormalities 0 trials
- Neurodevelopmental disorder with microcephaly, movement abnormalities, and seizures 0 trials
- Neurodevelopmental disorder with microcephaly, seizures, and brain atrophy 0 trials
- Neurodevelopmental disorder with microcephaly, seizures, and cortical atrophy 0 trials
- Neurodevelopmental disorder with microcephaly, seizures, and neonatal cholestasis 0 trials
- Neurodevelopmental disorder with microcephaly, short stature, and speech delay 0 trials
- Neurodevelopmental disorder with midbrain and hindbrain malformations 0 trials
- Neurodevelopmental disorder with motor abnormalities, seizures, and facial dysmorphism 0 trials
- Neurodevelopmental disorder with motor and language delay, ocular defects, and brain abnormalities 0 trials
- Neurodevelopmental disorder with motor and speech delay and behavioral abnormalities 0 trials
- Neurodevelopmental disorder with motor regression, progressive spastic paraplegia, and oromotor dysfunction 0 trials
- Neurodevelopmental disorder with movement abnormalities, abnormal gait, and autistic features 0 trials
- Neurodevelopmental disorder with neuromuscular and skeletal abnormalities 0 trials
- Neurodevelopmental disorder with nonspecific brain abnormalities and with or without seizures 0 trials
- Neurodevelopmental disorder with or without anomalies of the brain, eye, or heart 0 trials
- Neurodevelopmental disorder with or without autism or seizures 0 trials
- Neurodevelopmental disorder with or without autistic features and/or structural brain abnormalities 0 trials
- Neurodevelopmental disorder with or without early-onset generalized epilepsy 0 trials
- Neurodevelopmental disorder with or without seizures and gait abnormalities 0 trials
- Neurodevelopmental disorder with or without variable movement or behavioral abnormalities 0 trials
- Neurodevelopmental disorder with poor growth and behavioral abnormalities 0 trials
- Neurodevelopmental disorder with poor growth and skeletal anomalies 0 trials
- Neurodevelopmental disorder with poor growth, large ears, and dysmorphic facies 0 trials
- Neurodevelopmental disorder with poor growth, seizures, and brain abnormalities 0 trials
- Neurodevelopmental disorder with poor language and loss of hand skills 0 trials
- Neurodevelopmental disorder with poor or absent speech, dysmorphic facies, and behavioral abnormalities 0 trials
- Neurodevelopmental disorder with progressive microcephaly, spasticity, and brain anomalies 0 trials
- Neurodevelopmental disorder with progressive movement abnormalities 0 trials
- Neurodevelopmental disorder with progressive spasticity and brain abnormalities 0 trials
- Neurodevelopmental disorder with progressive spasticity and brain white matter abnormalities 0 trials
- Neurodevelopmental disorder with regression, abnormal movements, loss of speech, and seizures 0 trials
- Neurodevelopmental disorder with relative macrocephaly and with or without cardiac or endocrine anomalies 0 trials
- Neurodevelopmental disorder with seizures and brain atrophy 0 trials
- Neurodevelopmental disorder with seizures and gingival overgrowth 0 trials
- Neurodevelopmental disorder with seizures and nonepileptic hyperkinetic movements 0 trials
- Neurodevelopmental disorder with seizures and speech and walking impairment 0 trials
- Neurodevelopmental disorder with seizures, hypotonia, and brain imaging abnormalities 0 trials
- Neurodevelopmental disorder with seizures, hypotonia, and variable spasticity 0 trials
- Neurodevelopmental disorder with seizures, microcephaly, and brain abnormalities 0 trials
- Neurodevelopmental disorder with seizures, spasticity, and complete or partial agenesis of the corpus callosum 0 trials
- Neurodevelopmental disorder with severe motor impairment and absent language 0 trials
- Neurodevelopmental disorder with severe motor impairment, absent language, cerebral hypomyelination, and brain atrophy 0 trials
- Neurodevelopmental disorder with short stature, prominent forehead, and feeding difficulties 0 trials
- Neurodevelopmental disorder with spastic quadriplegia and brain abnormalities with or without seizures 0 trials
- Neurodevelopmental disorder with spastic quadriplegia, optic atrophy, seizures, and structural brain anomalies 0 trials
- Neurodevelopmental disorder with spasticity and poor growth 0 trials
- Neurodevelopmental disorder with spasticity, cataracts, and cerebellar hypoplasia 0 trials
- Neurodevelopmental disorder with spasticity, seizures, and brain abnormalities 0 trials
- Neurodevelopmental disorder with spasticity, thin corpus callosum, and decreased brain white matter 0 trials
- Neurodevelopmental disorder with speech delay and behavioral abnormalities 0 trials
- Neurodevelopmental disorder with speech delay and variable ocular anomalies 0 trials
- Neurodevelopmental disorder with speech delay, movement abnormalities, and seizures 0 trials
- Neurodevelopmental disorder with speech impairment and dysmorphic facies 0 trials
- Neurodevelopmental disorder with speech impairment and with or without seizures 0 trials
- Neurodevelopmental disorder with speech or visual impairment and brain hypomyelination 0 trials
- Neurodevelopmental disorder with structural brain abnormalities and craniofacial abnormalities 0 trials
- Neurodevelopmental disorder with structural brain anomalies and dysmorphic facies 0 trials
- Neurodevelopmental disorder with thin corpus callosum, hypotonia, and absent language 0 trials
- Neurodevelopmental disorder with variable familial hypercholanemia 0 trials
- Neurodevelopmental disorder with visual defects and brain anomalies 0 trials
- Neurodevelopmental disorder with white matter abnormalities and gait disturbance 0 trials
- Neurodevelopmental disorder, mitochondrial, with abnormal movements and lactic acidosis, with or without seizures 0 trials
- Neurodevelopmental disorder, nonprogressive, with spasticity and transient opisthotonus 0 trials
- Otofacial neurodevelopmental syndrome 0 trials
- Parenti-mignot neurodevelopmental syndrome 0 trials
- Squalene synthase deficiency 0 trials
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Intellectual disability 137 trials · 174 incl. sub-types
10 sub-types
- Syndromic intellectual disability 2 trials · 38 incl. sub-types Sub-types →
- Intellectual disability, autosomal dominant 0 trials · 23 incl. sub-types Sub-types →
- X-linked intellectual disability 1 trial · 15 incl. sub-types Sub-types →
- Non-syndromic intellectual disability 0 trials · 10 incl. sub-types Sub-types →
- Intellectual disability, autosomal recessive 0 trials · 1 incl. sub-types Sub-types →
- NACC1-related neurodevelopmental disorder with epilepsy, cataracts and episodic irritability 0 trials
- PPP2R1A-related intellectual disability 0 trials
- SETD2-related neurodevelopmental disorder without or with macrocephaly/overgrowth 0 trials Sub-types →
- Intellectual developmental disorder and retinitis pigmentosa; IDDRP 0 trials
- Intellectual developmental disorder with polymicrogyria and seizures 0 trials
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Williams syndrome 18 trials
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Microcephaly 4 trials · 13 incl. sub-types
10 sub-types
- Isolated congenital microcephaly 0 trials · 8 incl. sub-types Sub-types →
- Microcephalic osteodysplastic primordial dwarfism 1 trial Sub-types →
- Amish lethal microcephaly 0 trials
- Isolated microcephaly 0 trials
- Microcephaly and chorioretinopathy 0 trials Sub-types →
- Microcephaly with intellectual disability 0 trials Sub-types →
- Microcephaly with lissencephaly and/or hydranencephaly 0 trials Sub-types →
- Microcephaly with or without chorioretinopathy, lymphedema, or intellectual disability 0 trials
- Microcephaly, progressive, with simplified gyral pattern and cerebellar hypoplasia 0 trials
- Microcephaly, seizures, and developmental delay 0 trials
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Atypical Rett syndrome 0 trials · 12 incl. sub-types
2 sub-types
- Developmental and epileptic encephalopathy, 2 10 trials
- FOXG1 disorder 2 trials
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Alternating hemiplegia 0 trials · 3 incl. sub-types
2 sub-types
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Aicardi syndrome 2 trials
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Hao-Fountain syndrome 0 trials
2 sub-types
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Toluene embryopathy 0 trials
Most studied deeper sub-types
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One-shot gene editor aims to correct a brain disorder at its source
Cure Stopped earlyThis trial tests whether a single injection of a gene-editing tool can safely correct a specific mutation in the CHD3 gene that causes Snijders Blok-Campeau syndrome, a condition marked by developmental delay and intellectual disability. The gene editor is delivered directly into…
Early phase 1 • Sponsor: Yongguo Yu • Aim: Cure
Last updated Aug 01, 2026 00:00 UTC
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Can a new drug tame seizures in two severe epilepsy syndromes?
Disease control Stopped earlyThis phase 3 trial tests whether soticlestat can reduce seizures in people with Dravet syndrome or Lennox-Gastaut syndrome who have already used fenfluramine. Participants take soticlestat as tablets or mini-tablets, and researchers measure changes in seizure frequency over the f…
Phase 3 • Sponsor: Takeda • Aim: Disease control
Last updated Sep 06, 2026 00:00 UTC
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Seizure drug safety trial halted early for dravet and LGS patients
Disease control Stopped earlyThis study looked at the long-term safety of soticlestat when added to standard seizure medicines for people with Dravet syndrome or Lennox-Gastaut syndrome. It included 352 children and adults who had already been in earlier studies. The trial was terminated early, so results ar…
Phase 3 • Sponsor: Takeda • Aim: Disease control
Last updated Sep 06, 2026 00:00 UTC
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New drug shows promise for Tough-to-Treat seizures in kids
Disease control Stopped earlyThis study looked at the long-term safety of soticlestat, an experimental drug, in children and adults with severe forms of epilepsy like Dravet syndrome and Lennox-Gastaut syndrome. Participants took soticlestat twice a day along with their usual seizure medicines. The study was…
Phase 2 • Sponsor: Takeda • Aim: Disease control
Last updated Sep 06, 2026 00:00 UTC
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New nasal spray aims to curb relentless hunger in rare genetic disorder
Disease control Stopped earlyThis study tests the long-term safety of a nasal spray called carbetocin for people with Prader-Willi syndrome who experience severe, constant hunger (hyperphagia). About 160 participants who completed a previous study will receive the spray three times daily. The goal is to see …
Phase 3 • Sponsor: ACADIA Pharmaceuticals Inc. • Aim: Disease control
Last updated Aug 19, 2026 00:00 UTC
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Brain training: behavioral therapy may rewire social circuits in autistic toddlers
Disease control Stopped earlyThis study investigates whether a 10-week behavioral intervention called JASPER can improve early communication skills and alter brain activity in toddlers and preschoolers with autism. Participants aged 18 to 59 months receive twice-weekly sessions focused on joint attention and…
Sponsor: Boston University Charles River Campus • Aim: Disease control
Last updated Jul 19, 2026 00:00 UTC
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Can virtual coaching close the autism care gap for black toddlers?
Disease control Stopped earlyThis trial tests whether a telehealth-based family navigation program helps Black toddlers under age 4 start autism-specific intervention faster after diagnosis. Families in the program receive up to four virtual sessions with a trained navigator who helps them find and enroll in…
Sponsor: University of North Carolina, Chapel Hill • Aim: Disease control
Last updated Jul 12, 2026 00:00 UTC
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New hope for rare hunger disorder: drug shows promise in Long-Term trial
Disease control Stopped earlyThis study tests whether ARD-101 can safely reduce extreme hunger and food-related behaviors in people with Prader-Willi syndrome over 12 months. About 90 participants who completed a prior study will take the drug daily and visit the clinic regularly. The goal is to improve qual…
Phase 3 • Sponsor: Aardvark Therapeutics, Inc. • Aim: Disease control
Last updated Jul 02, 2026 00:00 UTC
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Gene therapy trial for rare childhood epilepsy halted after just one patient
Disease control Stopped earlyThis trial tested a single dose of CAP-002 gene therapy in children aged 18 months to 8 years with STXBP1 encephalopathy, a rare genetic brain disorder causing seizures and developmental delays. The study aimed to check safety and whether it could reduce seizures and improve skil…
Phase 1/2 • Sponsor: Capsida Biotherapeutics, Inc. • Aim: Disease control
Last updated Jun 27, 2026 13:06 UTC
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Promising seizure drug study halted early
Disease control Stopped earlyThis study looked at the long-term safety of the drug NBI-921352 for people with a rare genetic seizure disorder called SCN8A-DEE. It was an extension of an earlier study, and participants took the drug alongside their usual seizure medications. The study was stopped early and on…
Phase 2 • Sponsor: Neurocrine Biosciences • Aim: Disease control
Last updated Jun 27, 2026 12:37 UTC
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Could a repurposed drug tame seizures in adult dravet patients?
Disease control Stopped earlyThis study tested the drug fenfluramine (FINTEPLA) in adults with Dravet syndrome whose seizures were not controlled by other medications. The trial was open-label and added fenfluramine to existing treatments. It aimed to see if the drug could reduce monthly seizures by at least…
Phase 3 • Sponsor: University Health Network, Toronto • Aim: Disease control
Last updated Jun 27, 2026 12:29 UTC
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Virtual coaching for toddlers with autism shows promise but trial cut short
Disease control Stopped earlyThis study tested a completely virtual early intervention program for toddlers with autism, using telehealth coaching to help parents embed learning into daily activities. Researchers planned to enroll 240 children from eight US regions, but the trial was terminated early with on…
Sponsor: Florida State University • Aim: Disease control
Last updated Jun 27, 2026 09:06 UTC
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Epilepsy drug study for kids halted early: what we know
Disease control Stopped earlyThis study looked at the long-term safety of a drug called NBI-827104 in children with a rare epilepsy that causes seizures during sleep. The trial was stopped early and only enrolled 19 children, so the results are limited. The main goal was to see how many children had serious …
Phase 2 • Sponsor: Neurocrine Biosciences • Aim: Disease control
Last updated Jun 27, 2026 09:05 UTC
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Promising epilepsy drug trial halted early – what we know
Disease control Stopped earlyThis study tested an experimental drug called NBI-921352 in people aged 2 to 21 with a rare, severe form of epilepsy caused by a change in the SCN8A gene. The goal was to see if adding this drug to their current seizure medicines could reduce how often they had seizures. The tria…
Phase 2 • Sponsor: Neurocrine Biosciences • Aim: Disease control
Last updated Jun 27, 2026 07:54 UTC
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Dravet syndrome drug trial halted early: did lorcaserin help?
Disease control Stopped earlyThis study tested whether lorcaserin, when added to current medications, could reduce convulsive seizures in people with Dravet syndrome, a severe form of epilepsy. The trial planned to enroll about 22 participants aged 2 and older, but it was terminated early. The main goal was …
Phase 3 • Sponsor: Eisai Inc. • Aim: Disease control
Last updated Jun 27, 2026 07:53 UTC
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Can a gut microbe ease Autism's social struggles?
Symptom relief Stopped earlyThis trial tests whether a daily probiotic supplement called Lactobacillus plantarum PS128 can improve social and behavioral symptoms in children with autism spectrum disorder. School-aged children (7-12 years) will receive either the probiotic or a placebo for a period, and rese…
Sponsor: Chang Gung Memorial Hospital • Aim: Symptom relief
Last updated Aug 26, 2026 00:00 UTC
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Hope for rare hunger disorder: new drug enters final testing phase
Symptom relief Stopped earlyThis phase 3 trial tests whether ARD-101 can reduce the intense, constant hunger (hyperphagia) seen in Prader-Willi syndrome. About 90 participants will take either ARD-101 or a placebo daily for 12 weeks. Caregivers will track changes in hunger-related behaviors using a standard…
Phase 3 • Sponsor: Aardvark Therapeutics, Inc. • Aim: Symptom relief
Last updated Jul 02, 2026 00:00 UTC
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CBDV study for Prader-Willi syndrome halted early
Symptom relief Stopped earlyThis study tested whether a cannabis-derived compound called CBDV could safely reduce irritability in children and young adults with Prader-Willi syndrome. Only 6 people enrolled before the study was stopped early. The goal was to see if CBDV helped with mood and behavior problem…
Phase 2 • Sponsor: Eric Hollander • Aim: Symptom relief
Last updated Jun 27, 2026 12:30 UTC
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Autism social trial halted: memantine shows no promise
Symptom relief Stopped earlyThis study tested whether memantine, a medication for Alzheimer's, could improve social skills in youth aged 8-18 with autism or nonverbal learning disability. The trial was stopped early after enrolling only 25 participants. The main goal was to measure changes in social functio…
Phase 3 • Sponsor: Massachusetts General Hospital • Aim: Symptom relief
Last updated Jun 27, 2026 09:08 UTC
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Autism irritability drug trial ends early: what happened?
Symptom relief Stopped earlyThis study looked at the long-term safety of pimavanserin for treating irritability in children and teens (ages 5-17) with autism. It was an extension of an earlier 6-week study, lasting 52 weeks. The trial was terminated early, and results are not yet fully available.
Phase 2/3 • Sponsor: ACADIA Pharmaceuticals Inc. • Aim: Symptom relief
Last updated Jun 27, 2026 08:01 UTC
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CBD study for baby seizures halted early
Symptom relief Stopped earlyThis study tested a cannabidiol (CBD) oral solution in children under 2 years old with tuberous sclerosis complex, Dravet syndrome, or Lennox-Gastaut syndrome who had uncontrolled seizures. The goal was to see if CBD is safe and can reduce seizures. However, the study was termina…
Phase 3 • Sponsor: Jazz Pharmaceuticals • Aim: Symptom relief
Last updated Jun 27, 2026 07:56 UTC
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5-Minute wellness program for caregivers shows promise, study cut short
Symptom relief Stopped earlyThis study tested a program called 5Minutes4Myself, designed to help caregivers of autistic children (ages 8-21) manage stress and improve their well-being. Participants worked with a coach to create a personalized wellness plan and used a phone app with reminders and mindfulness…
Sponsor: University of Wisconsin, Madison • Aim: Symptom relief
Last updated Jun 27, 2026 07:55 UTC
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Glutathione study for autism fizzles out early
Symptom relief Stopped earlyThis study aimed to see if taking glutathione by mouth is safe and practical for children and teens with autism. Researchers planned to enroll 24 participants but stopped early with only 6. The goal was to measure changes in behavior and social skills over 12 weeks.
Phase 4 • Sponsor: University of Chicago • Aim: Symptom relief
Last updated Jun 26, 2026 18:02 UTC
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Sibling power: could brothers and sisters be the key to autism therapy?
Symptom relief Stopped earlyThis study explored whether training typically developing siblings to teach reading and social skills can help children with autism. The approach used a simple teaching method called model-lead-test, where the sibling shows, practices, and gives feedback. Only 8 families took par…
Sponsor: Arizona State University • Aim: Symptom relief
Last updated Jun 26, 2026 16:44 UTC
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Zapping the brain to unravel OCD in kids
Knowledge-focused Stopped earlyThis study looked at how a gentle brain stimulation technique called tDCS affects thinking and behavior in children aged 10-17 with obsessive-compulsive disorder (OCD). The goal was to understand brain processes linked to OCD, not to treat the condition. Only 6 participants were …
Sponsor: Massachusetts General Hospital • Aim: Knowledge-focused
Last updated Jul 12, 2026 00:00 UTC
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Brain and eye clues to emotion recognition in autism and psychosis
Knowledge-focused Stopped earlyThis study aimed to understand why people with autism or schizophrenia sometimes struggle to recognize emotions on faces. Researchers used brain wave recordings (EEG) and eye-tracking to see how participants processed facial expressions. The study included people with autism, sch…
Sponsor: Hôpital le Vinatier • Aim: Knowledge-focused
Last updated Jun 27, 2026 13:07 UTC
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Brain scans reveal how autistic people process sensory overload
Knowledge-focused Stopped earlyThis study aimed to understand why people with autism often feel overwhelmed by sensory input like bright lights or loud noises. Researchers planned to use virtual reality and brain scans to see how the brain reacts to unpleasant visual stimuli. The study was terminated early and…
Sponsor: University of Nebraska • Aim: Knowledge-focused
Last updated Jun 27, 2026 13:00 UTC
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Scientists hunt for clues in rare genetic brain disorder
Knowledge-focused Stopped earlyThis study aimed to observe how MECP2 duplication syndrome progresses over time by measuring biological markers in spinal fluid and blood, and by tracking changes in development, behavior, and seizures. It enrolled 29 males aged 1 month to 65 years with a confirmed genetic diagno…
Sponsor: Ionis Pharmaceuticals, Inc. • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:05 UTC
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Rare disease study aims to map MLIV's natural course
Knowledge-focused Stopped earlyThis study followed 7 people with Mucolipidosis Type IV (MLIV) to learn how the disease naturally progresses. Researchers used tests like neuropsychological exams, blood and urine tests, and brain MRIs to find better ways to measure the disease. The goal was to improve future cli…
Sponsor: Baylor Research Institute • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:14 UTC
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Can an eHealth program help teachers support kids with ADHD, autism, and learning disabilities?
Knowledge-focused Stopped earlyThis study tested an online program called Teacher Help, designed to train teachers in evidence-based strategies for students with ADHD, autism spectrum disorder, or learning disabilities. Teachers worked through six online sessions with support from school psychologists. The goa…
Sponsor: IWK Health Centre • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:51 UTC