Monkeypox

This large study will test the LC16m8 mpox vaccine in nearly 12,000 people aged one year and older in the Democratic Republic of Congo. Researchers want to see if the vaccine can prevent mpox disease and monitor its safety. Participants will receive the vaccine as part of the gov…

This study tests an experimental mRNA vaccine called BNT166a to see if it is safe and can protect against mpox (monkeypox). About 310 healthy adults in Africa will receive either the vaccine or a placebo. The trial is double-blind, meaning neither participants nor doctors know wh…

This study is testing a new vaccine called JT118 to see if it is safe and triggers an immune response against monkeypox. About 180 healthy adults aged 18 to 59 will receive either the vaccine or a placebo. Researchers will monitor for side effects and measure immune responses ove…

This early-stage trial is testing a new vaccine against monkeypox in 120 healthy adults aged 18 and older. Participants will receive two doses of either a low or high dose of the MVA strain live vaccine, or a placebo. The study aims to check if the vaccine is safe and whether it …

This study tests whether specially grown donor immune cells (viral-specific T-cells) can safely treat viral infections that often occur after a stem cell transplant. These infections can be serious and sometimes don't respond to standard antiviral drugs. The approach aims to boos…

This study tests whether giving patients donor-derived immune cells (VSTs) on a regular schedule can prevent dangerous viral infections after a stem cell transplant. 180 participants will be randomly assigned to receive VSTs either on a fixed schedule or only when a virus is dete…

This trial tests the drug tecovirimat in people who have been exposed to or infected with orthopox viruses, including smallpox, monkeypox, and cowpox. Participants receive oral tecovirimat to see if it can control the infection and prevent serious complications. The study include…

This study tests a new way to collect and transport samples for mpox diagnosis using a special paper strip treated with SDS and EDTA. The strip inactivates the virus, making transport safer, and stabilizes the genetic material so cold storage isn't needed. Researchers will compar…

This study looks at how the monkeypox vaccine (MVA-BN) sparks immune responses in 100 adults at high risk of infection, including those with and without HIV. Researchers will measure antibodies and other immune markers in blood samples taken after vaccination. The goal is to unde…

This study follows 345 people who had mpox or received the smallpox vaccine to see if there are any long-term physical or mental health problems. Researchers will also check how long the body's immune memory lasts by testing blood, saliva, semen, and anal swabs over 5 years. Part…

This early-stage study tests the safety and how the body processes a new drug called BSY001 in 76 healthy adults aged 18 to 50. Participants receive either the drug or a placebo, and researchers monitor side effects and drug levels in the blood. The goal is to gather safety infor…

This study will follow 30 adults who have received vaccines or antibody treatments for COVID-19 or monkeypox. Researchers will take blood and optional nasal swabs over time to measure how well the body's antibodies neutralize these viruses. The goal is to better understand how lo…