Male infertility
MONDO:0005372The inability of the male to effect fertilization of an ovum after a specified period of unprotected intercourse. Male sterility is permanent infertility.
Also known as: infertility disorder of male reproductive system, male reproductive system infertility, male reproductive system infertility disorder
92 clinical trials for this condition and its sub-types, 74 tagged with Male infertility itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Sub-types of Male infertility
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Azoospermia 25 trials
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Oligospermia 20 trials
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Spermatogenic failure 1 trial · 12 incl. sub-types
113 sub-types
- Spermatogenic failure 3 9 trials
- Spermatogenic failure, Y-linked, 2 5 trials
- Spermatogenic failure 34 1 trial
- Spermatogenic failure 6 1 trial
- X-linked spermatogenic failure 1 0 trials
- Spermatogenic failure 1 0 trials
- Spermatogenic failure 10 0 trials
- Spermatogenic failure 100 0 trials
- Spermatogenic failure 101 0 trials
- Spermatogenic failure 102 0 trials
- Spermatogenic failure 11 0 trials
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- Spermatogenic failure 16 0 trials
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- Spermatogenic failure 2 0 trials
- Spermatogenic failure 20 0 trials
- Spermatogenic failure 21 0 trials
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- Spermatogenic failure 96 0 trials
- Spermatogenic failure 97 0 trials
- Spermatogenic failure 98 0 trials
- Spermatogenic failure 99 0 trials
- Spermatogenic failure, X-linked, 2 0 trials
- Spermatogenic failure, X-linked, 3 0 trials
- Spermatogenic failure, X-linked, 4 0 trials
- Spermatogenic failure, X-linked, 5 0 trials
- Spermatogenic failure, X-linked, 6 0 trials
- Spermatogenic failure, X-linked, 7 0 trials
- Spermatogenic failure, X-linked, 8 0 trials
- Spermatogenic failure, X-linked, 9 0 trials
- Spermatogenic failure, Y-linked, 1 0 trials
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Oligoasthenoteratozoospermia 11 trials
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Partial chromosome Y deletion 0 trials · 5 incl. sub-types
3 sub-types
- Spermatogenic failure, Y-linked, 2 5 trials
- Y chromosome infertility due to DAZ1 deletion 0 trials
- Spermatogenic failure, Y-linked, 1 0 trials
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Male infertility with teratozoospermia due to single gene mutation 0 trials · 1 incl. sub-types
3 sub-types
- Male infertility due to globozoospermia 0 trials · 1 incl. sub-types Sub-types →
- Spermatogenic failure 12 0 trials
- Spermatogenic failure 5 0 trials
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Could immature sperm cells help infertile men become fathers?
Disease control Recruiting nowThis study tests whether round spermatids (immature sperm cells) can be used in IVF to help men with a condition called non-obstructive azoospermia, where no mature sperm are present. Researchers will collect these cells from the testicles and inject them into eggs to see if they…
Sponsor: Wake Forest University Health Sciences • Aim: Disease control
Last updated Sep 19, 2026 00:00 UTC
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New male contraceptive device aims to be reversible
Disease control Recruiting nowThis study is testing a new device called Plan A that blocks sperm from passing through the vas deferens, similar to a vasectomy, but designed to be reversed later. Forty healthy men aged 25 to 65 will receive the device and be monitored for safety and effectiveness. The goal is …
Phase 2 • Sponsor: Next Life Sciences • Aim: Disease control
Last updated Sep 17, 2026 00:00 UTC
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New sperm sorter may boost IVF success for dads over 40
Disease control Recruiting nowThis study tests a new device that sorts sperm without spinning them, which may reduce DNA damage often seen in older men. It involves 378 couples where the male partner is 40 or older and the female partner has at least 5 mature eggs. The goal is to see if this device leads to m…
Sponsor: Vietnam Military Medical University • Aim: Disease control
Last updated Aug 22, 2026 00:00 UTC
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Bee superfood tested as fertility aid for unexplained infertility
Disease control Recruiting nowThis study tests whether taking royal jelly, a bee product, can improve sperm DNA quality and pregnancy rates in couples with unexplained infertility. Eighty men will take either royal jelly or a placebo daily for three months. Researchers will measure sperm damage, hormone level…
Sponsor: Medipol University • Aim: Disease control
Last updated Aug 21, 2026 00:00 UTC
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New gel could boost fertility for couples struggling to conceive
Disease control Recruiting nowThis study tests a gel called PKB171, which contains a drug used to improve blood flow and sperm movement. Couples with mild male infertility who have been trying to conceive for 6 to 24 months apply the gel after sex. The goal is to see if it increases pregnancy rates compared t…
Phase 2/3 • Sponsor: Prokrea BCN, S.L. • Aim: Disease control
Last updated Jun 27, 2026 14:02 UTC
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One cut instead of two: could a single incision improve varicocele surgery recovery?
Disease control Recruiting nowThis study tests whether a single midline incision in the pubic area works as well as the standard two incisions (one on each side) for repairing varicoceles in both testicles. The trial enrolls men aged 18 to 45 with a palpable bilateral varicocele and infertility lasting at lea…
Sponsor: Beni-Suef University • Aim: Disease control
Last updated Jun 27, 2026 14:00 UTC
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Frozen testicle tissue may help men have kids after cancer
Disease control Recruiting nowThis study tests a new way to help men who lost fertility due to cancer or autoimmune treatments. Doctors will transplant the patient's own frozen testicular tissue back into them. The goal is to see if it is safe and can restart sperm production.
Sponsor: University of Pittsburgh • Aim: Disease control
Last updated Jun 27, 2026 12:23 UTC
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Diet over drugs: Low-Carb plan aims to improve sperm in obese men
Disease control Recruiting nowThis study tests whether a strict low-carbohydrate diet combined with lifestyle guidance can help obese men (BMI 30+) lose weight and improve their fertility. Researchers will track weight, semen quality, and reproductive outcomes in 98 men aged 22-40. The goal is to find a non-d…
Sponsor: Third Affiliated Hospital of Zhengzhou University • Aim: Disease control
Last updated Jun 27, 2026 12:06 UTC
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Cold soup, hot sperm: gazpacho diet tested for male fertility
Disease control Recruiting nowThis study looks at whether drinking a daily serving of gazpacho, a cold tomato-based soup, can improve semen quality in men with low sperm counts or poor sperm movement. Eighty men will follow a Mediterranean diet for 12 weeks, with half also drinking gazpacho each day. Research…
Sponsor: Ginefiv • Aim: Disease control
Last updated Jun 27, 2026 11:00 UTC
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Fertility breakthrough? new study tests Sperm-Shape fix for better baby chances
Disease control Recruiting nowThis study compares two IVF methods for couples where the male partner has severe sperm shape issues (teratospermia). One group gets standard ICSI (sperm injected into egg), the other gets ICSI plus a chemical boost to activate the egg. The goal is to see which leads to more live…
Sponsor: ShangHai Ji Ai Genetics & IVF Institute • Aim: Disease control
Last updated Jun 27, 2026 09:01 UTC
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Could probiotics boost sperm quality? new trial aims to find out
Disease control Recruiting nowThis study tests whether taking probiotics daily for about 100 days can improve sperm count, movement, and shape in men with infertility. Sixty men aged 20 to 45 will be randomly assigned to receive either probiotics or a placebo. Researchers will measure sperm quality at the sta…
Sponsor: Mackay Memorial Hospital • Aim: Disease control
Last updated Jun 27, 2026 08:11 UTC
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Could a blood draw help men with no sperm become fathers?
Disease control Recruiting nowThis Stanford study tests whether injecting a man's own platelet-rich plasma (PRP) into his testicles can help produce sperm. Ten men with nonobstructive azoospermia who previously failed sperm retrieval will receive the injection. Three months later, doctors will check for sperm…
Sponsor: Stanford University • Aim: Disease control
Last updated Jun 27, 2026 08:10 UTC
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Spinal cord injury infertility: could a common drug boost sperm movement?
Symptom relief Recruiting nowThis study tests a medicine called probenecid to see if it can improve sperm movement in men with spinal cord injury. Many of these men have normal sperm counts, but their sperm don't swim well, causing infertility. The trial will enroll 90 men and measure changes in sperm qualit…
Phase 3 • Sponsor: University of Miami • Aim: Symptom relief
Last updated Jun 27, 2026 09:09 UTC
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Could freezing sperm outsmart father time?
Knowledge-focused Recruiting nowResearchers at IVI Murcia are studying whether freezing sperm can preserve its quality and molecular features that may decline with age. Men aged 18 to 65 provide a semen sample and a blood sample. Each semen sample is split into fresh, slow-frozen, and vitrified portions. The te…
Sponsor: IVI Murcia • Aim: Knowledge-focused
Last updated Sep 12, 2026 00:00 UTC
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New sperm-boosting method tested in 300 men
Knowledge-focused Recruiting nowThis study tests a new lab technique called HyperSperm to see if it can make sperm move better and stay healthy. Researchers will collect semen samples from 300 men with different fertility issues and compare the new method to the standard one. The goal is to find a safer and mor…
Sponsor: Fecundis Lab SL • Aim: Knowledge-focused
Last updated Sep 03, 2026 00:00 UTC
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Mitochondrial DNA mutation may be a hidden cause of male infertility
Knowledge-focused Recruiting nowThis study investigates whether a specific mitochondrial DNA variant (MT-ND1 m.3700G>A) is associated with severe male infertility, specifically conditions where sperm production is absent or extremely low. Researchers analyzed existing medical records and biological samples from…
Sponsor: The Third Affiliated Hospital of Guangzhou Medical University • Aim: Knowledge-focused
Last updated Jul 11, 2026 00:00 UTC
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Sperm protein could be key to unlocking male infertility
Knowledge-focused Recruiting nowThis study looks at whether levels of a sperm protein called PLCZeta are linked to semen quality and fertility outcomes. Researchers will measure PLCZeta in sperm samples from couples undergoing IVF or routine semen analysis. The goal is to see if low or abnormal PLCZeta predicts…
Sponsor: Fakih IVF Fertility Center • Aim: Knowledge-focused
Last updated Jul 08, 2026 00:00 UTC
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AI could predict which sperm will lead to a baby
Knowledge-focused Recruiting nowThis study is developing an artificial intelligence (AI) platform to analyze sperm samples and predict how likely they are to lead to a successful pregnancy during IVF. Researchers will collect and study 500 semen samples from men undergoing IVF, using AI to look for patterns tha…
Sponsor: Fecundis Lab SL • Aim: Knowledge-focused
Last updated Jun 27, 2026 13:07 UTC
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New biobank aims to unlock secrets of male infertility
Knowledge-focused Recruiting nowThis study is creating a biobank of male biological samples, such as sperm and testicular tissue, from men undergoing fertility treatments. The goal is to collect and store these samples for future research on male infertility and assisted reproductive technologies. Up to 1,000 p…
Sponsor: Reproductive Medicine Associates of New Jersey • Aim: Knowledge-focused
Last updated Jun 27, 2026 13:02 UTC
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Diamonds and sperm: a new way to detect fertility problems?
Knowledge-focused Recruiting nowThis study is testing a new technique called diamond magnetometry to measure free radicals in individual sperm cells and blood. Free radicals are natural but can damage sperm if out of balance. Researchers will also look at the bacteria in semen and how lifestyle and diet affect …
Sponsor: University Medical Center Groningen • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:30 UTC
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Diet change may boost sperm health in IVF couples
Knowledge-focused Recruiting nowThis study looks at whether a short diet change can improve sperm quality in men whose partners are undergoing IVF. One hundred couples in Sweden will take part. Men will follow Nordic dietary guidelines for a few weeks. Researchers will check sperm count, movement, and small RNA…
Sponsor: Ostergotland County Council, Sweden • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:29 UTC
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Fertility study asks: are men still overlooked in IVF clinics?
Knowledge-focused Recruiting nowThis study surveys 400 men undergoing ICSI due to low sperm quality. Researchers want to understand their emotional experiences, social burden, and testosterone levels, and compare results to a similar study from 2008. The goal is to see if men's needs in fertility care have chan…
Sponsor: Peter Humaidan • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:23 UTC
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Researchers decode ancient medicine patterns for male fertility
Knowledge-focused Recruiting nowThis observational study aims to identify and classify Traditional Medicine (TM) syndromes in men aged 18 to 60 with male infertility and oligoasthenoteratozoospermia (OAT) syndrome. Researchers will first review TM literature to list symptoms, then survey 300 participants and us…
Sponsor: University of Medicine and Pharmacy at Ho Chi Minh City • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:07 UTC
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Scientists probe gene behind male infertility and cystic fibrosis
Knowledge-focused Recruiting nowThis observational study aims to understand how the CFTR gene is regulated in epididymal cells, which may help explain male infertility linked to cystic fibrosis. Researchers will collect leftover tissue samples from 20 men already scheduled for surgery. No extra procedures are n…
Sponsor: University Hospital, Brest • Aim: Knowledge-focused
Last updated Jun 27, 2026 11:03 UTC