Male infertility
MONDO:0005372The inability of the male to effect fertilization of an ovum after a specified period of unprotected intercourse. Male sterility is permanent infertility.
Also known as: infertility disorder of male reproductive system, male reproductive system infertility, male reproductive system infertility disorder
92 clinical trials for this condition and its sub-types, 74 tagged with Male infertility itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Sub-types of Male infertility
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Azoospermia 25 trials
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Oligospermia 20 trials
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Spermatogenic failure 1 trial · 12 incl. sub-types
113 sub-types
- Spermatogenic failure 3 9 trials
- Spermatogenic failure, Y-linked, 2 5 trials
- Spermatogenic failure 34 1 trial
- Spermatogenic failure 6 1 trial
- X-linked spermatogenic failure 1 0 trials
- Spermatogenic failure 1 0 trials
- Spermatogenic failure 10 0 trials
- Spermatogenic failure 100 0 trials
- Spermatogenic failure 101 0 trials
- Spermatogenic failure 102 0 trials
- Spermatogenic failure 11 0 trials
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- Spermatogenic failure 2 0 trials
- Spermatogenic failure 20 0 trials
- Spermatogenic failure 21 0 trials
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- Spermatogenic failure 26 0 trials
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- Spermatogenic failure 30 0 trials
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- Spermatogenic failure 95 0 trials
- Spermatogenic failure 96 0 trials
- Spermatogenic failure 97 0 trials
- Spermatogenic failure 98 0 trials
- Spermatogenic failure 99 0 trials
- Spermatogenic failure, X-linked, 2 0 trials
- Spermatogenic failure, X-linked, 3 0 trials
- Spermatogenic failure, X-linked, 4 0 trials
- Spermatogenic failure, X-linked, 5 0 trials
- Spermatogenic failure, X-linked, 6 0 trials
- Spermatogenic failure, X-linked, 7 0 trials
- Spermatogenic failure, X-linked, 8 0 trials
- Spermatogenic failure, X-linked, 9 0 trials
- Spermatogenic failure, Y-linked, 1 0 trials
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Oligoasthenoteratozoospermia 11 trials
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Partial chromosome Y deletion 0 trials · 5 incl. sub-types
3 sub-types
- Spermatogenic failure, Y-linked, 2 5 trials
- Y chromosome infertility due to DAZ1 deletion 0 trials
- Spermatogenic failure, Y-linked, 1 0 trials
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Male infertility with teratozoospermia due to single gene mutation 0 trials · 1 incl. sub-types
3 sub-types
- Male infertility due to globozoospermia 0 trials · 1 incl. sub-types Sub-types →
- Spermatogenic failure 12 0 trials
- Spermatogenic failure 5 0 trials
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Surgery for enlarged scrotum veins may boost sperm health by reducing immature cells
Disease control Not yet recruitingThis study looks at how surgery to fix varicocele—enlarged veins in the scrotum—affects the number of immature sperm cells in semen. Infertile men aged 20 to 45 with varicocele will have a microsurgical procedure to tie off the abnormal veins. Their semen will be tested before su…
Sponsor: Assiut University • Aim: Disease control
Last updated Jul 08, 2026 00:00 UTC
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New surgical twist may boost fertility after varicocele repair
Disease control Not yet recruitingThis study tests a more thorough varicocele surgery that strips away extra veins, compared to the standard method. About 160 infertile men with varicocele will be randomly assigned to one of the two procedures. The goal is to see if the extended stripping reduces the chance of va…
Sponsor: Benha University • Aim: Disease control
Last updated Jun 27, 2026 12:37 UTC
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Could a weekly pill help men with no sperm become fathers?
Disease control Not yet recruitingThis early study tests a drug called leflutrozole in 15 men who have no sperm in their semen due to a blockage-free cause. The drug is taken as a weekly capsule and aims to boost sperm production. Researchers will check if sperm appear in the semen after 12-20 weeks of treatment.
Phase 1/2 • Sponsor: Martin Blomberg Jensen • Aim: Disease control
Last updated Jun 27, 2026 12:29 UTC
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Hormone shots may help infertile men avoid surgery
Disease control Not yet recruitingThis study tests whether giving men with low testosterone and no sperm in their ejaculate a combination of two hormones (hCG and FSH) can help them produce usable sperm for IVF. About 860 men will either receive the hormone therapy or standard care for 16 weeks. The goal is to se…
Sponsor: Indira IVF Hospital Pvt Ltd • Aim: Disease control
Last updated Jun 27, 2026 12:09 UTC
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AI-Powered sperm selection could boost IVF success
Disease control Not yet recruitingThis study tests an AI-driven device called BAIBYS™ that automatically selects sperm based on movement, size, and shape for use in IVF. Half of the eggs from each couple will be fertilized using sperm chosen by the AI, and the other half using the standard manual method. The goal…
Sponsor: BAIBYS Fertility • Aim: Disease control
Last updated Jun 27, 2026 08:11 UTC
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Could ozempic help men become fathers? new trial investigates
Disease control Not yet recruitingThis study tests whether two popular weight-loss drugs, semaglutide and tirzepatide, can improve sperm quality and help obese men have children naturally. About 180 men will receive either lifestyle advice, semaglutide, or tirzepatide for 32 weeks. Researchers will measure change…
Phase 2 • Sponsor: First Affiliated Hospital of Wenzhou Medical University • Aim: Disease control
Last updated Jun 26, 2026 17:30 UTC
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New AI tool could revolutionize male fertility testing for IVF
Diagnosis Not yet recruitingThis study aims to develop and validate an artificial intelligence tool that analyzes sperm quality using microfluidic technology. Researchers will test the tool on 200 men undergoing IVF or artificial insemination. The goal is to provide a more accurate, standardized diagnosis a…
Sponsor: Instituto Valenciano de Infertilidad, IVI VALENCIA • Aim: Diagnosis
Last updated Jun 27, 2026 07:51 UTC
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AI could take the guesswork out of sperm selection for IVF
Diagnosis Not yet recruitingThis study tests an artificial intelligence algorithm called SiDTM v2.0 that helps embryologists choose the best sperm for a procedure called ICSI (a type of IVF). Currently, sperm selection is done by eye, which can vary between experts. The AI scores each sperm based on shape a…
Sponsor: Instituto Valenciano de Infertilidad, IVI VALENCIA • Aim: Diagnosis
Last updated Jun 26, 2026 14:46 UTC
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Could a healthier lifestyle repair sperm DNA and boost fertility?
Knowledge-focused Not yet recruitingThis study looks at whether damage to sperm DNA (called sperm DNA fragmentation) is common in men undergoing fertility treatment and whether it affects the chance of a live birth. About 800 men will provide semen and blood samples. Those with high sperm DNA damage (above 20%) wil…
Sponsor: Regionshospitalet Viborg, Skive • Aim: Knowledge-focused
Last updated Aug 23, 2026 00:00 UTC
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Fertility breakthrough? education on everyday chemicals may boost sperm count
Knowledge-focused Not yet recruitingThis study tests whether a behavioral education program can help men with low sperm quality reduce their exposure to endocrine disrupting chemicals (EDCs) found in everyday products. Participants complete 14 online modules over 8 weeks, and researchers measure changes in environm…
Sponsor: Million Marker Wellness, Inc. • Aim: Knowledge-focused
Last updated Jul 16, 2026 00:00 UTC
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Sperm DNA damage may predict IVF success, new study aims to find thresholds
Knowledge-focused Not yet recruitingThis study will follow about 484 couples undergoing a type of IVF called ICSI to see if sperm DNA damage affects their chances of having a baby. Researchers will measure DNA breaks in sperm before and after a washing step, then track pregnancy and live birth rates. The goal is to…
Sponsor: Indira IVF Hospital Pvt Ltd • Aim: Knowledge-focused
Last updated Jun 27, 2026 13:02 UTC
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Massive study to uncover cancer Therapy's hidden toll on fertility
Knowledge-focused Not yet recruitingThis large observational study will follow 4,000 young cancer survivors (ages 15-39) across Europe to understand how different cancer treatments impact fertility, hormone function, and pregnancy outcomes. Researchers will also evaluate the safety and success of fertility preserva…
Sponsor: Karolinska Institutet • Aim: Knowledge-focused
Last updated Jun 27, 2026 13:02 UTC
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New IVF study tests calcium boosters for fertilization failures
Knowledge-focused Not yet recruitingThis study tests two different calcium treatments (ionophores) to help eggs fertilize during IVF when previous attempts failed. Researchers will compare which treatment works better and check embryo health. The study involves 20 couples with a history of low fertilization.
Sponsor: ART Fertility Clinics LLC • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:31 UTC
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Testicle blood flow may predict fertility surgery success
Knowledge-focused Not yet recruitingThis study looks at 40 infertile men with varicoceles (enlarged veins in the scrotum) to see if blood flow measurements in the testicles can predict how well they will respond to surgery. Participants will have ultrasound and blood tests before and three months after a standard m…
Sponsor: Assiut University • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:05 UTC
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New study maps male infertility across india – no treatment, just answers
Knowledge-focused Not yet recruitingThis study will look at over 1,000 men visiting fertility clinics across India to understand how common male infertility is and what factors like smoking, obesity, and location might play a role. Researchers will use a new system called the Aphrodite Criteria to get a clearer pic…
Sponsor: Indira IVF Hospital Pvt Ltd • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:14 UTC
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Heart drug warfarin under scrutiny for male fertility risks
Knowledge-focused Not yet recruitingThis pilot study will follow 90 men aged 18-50 who need heart surgery, some of whom will take the blood thinner warfarin afterward. Researchers will track changes in sperm count, movement, shape, DNA health, and hormone levels over 12 months. The goal is to see if warfarin harms …
Sponsor: Città di Lecce Hospital, GVM Care & Research • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:10 UTC