Laryngeal disorder

This phase 2 trial tests an experimental drug called ficerafusp alfa, which targets two proteins that help tumors grow, when given with the immunotherapy pembrolizumab. The study enrolls adults with recurrent or metastatic head and neck squamous cell carcinoma that has not been t…

This study tests whether adding an experimental drug called ficerafusp alfa to the immunotherapy pembrolizumab (Keytruda) works better than pembrolizumab alone for people with PD-L1-positive head and neck cancer that has spread or returned. About 650 adults will be randomly assig…

This study tests whether adding petosemtamab to the standard immunotherapy pembrolizumab helps people with advanced head and neck cancer live longer. About 700 adults with PD-L1 positive cancer that has spread or come back will receive either the combination or pembrolizumab alon…

This study compares two ways of giving the chemotherapy drug 5-FU to people with head and neck cancer that has spread or come back after prior treatments. One group gets the drug over two days every two weeks, the other over four days every three weeks. The goal is to see which s…

This study tests which chemotherapy combination works better when given with radiation for advanced head and neck cancer. About 120 adults with stage III or IV disease will receive either cisplatin or a mix of docetaxel and cetuximab. Researchers will also check if a tumor marker…

This study tests whether a new type of radiation machine that uses MRI to guide treatment is safe and practical for people with gastric, breast, or other cancers. About 70 adults will receive radiation guided by real-time MRI, sometimes with chemotherapy. The goal is to see if th…

This study tests an experimental drug called VMD-928, taken as a pill, either alone or with another cancer drug (pembrolizumab). It is for adults with advanced solid tumors or lymphoma that have not responded to or are no longer controlled by available treatments. The goal is to …

This phase II trial compares a new, shorter radiation schedule (LT-SABR, given over 1-2 weeks) to standard radiation (over 5-6 weeks) for early-stage laryngeal cancer. The goal is to see if the shorter schedule causes fewer severe side effects in the first 3 months. About 67 adul…

This study is developing an artificial intelligence system that can recognize different parts of the throat and nasal passages and detect abnormal growths or lesions. Researchers will train the AI using thousands of endoscopy images and then test its accuracy against doctors with…

This study is testing a new device that measures how sensitive the throat is to help diagnose obstructive sleep apnea (OSA). Researchers will compare the results of this test with standard sleep studies in 117 adults. The goal is to see if this simpler, quicker test can accuratel…

This trial investigates whether a single steroid injection into the arm muscle can reduce symptoms of unexplained chronic cough. About 40 adults with chronic cough that has no clear cause will receive either the steroid or a placebo injection. Researchers will track changes in co…

This study tests whether a 20-minute session of passive music therapy, delivered through an app just before entering the operating room, can lower anxiety and pain in adults undergoing ear, nose, or throat surgery. Five hundred participants will be randomly assigned to receive mu…

This study tests whether a numbing injection (nerve block) given during vocal cord surgery can reduce pain, coughing, and improve voice recovery afterward. About 28 adults with benign vocal cord growths will receive either the numbing medicine or a saltwater placebo. Researchers …

This study aims to create a large collection of tissue samples from people with head and neck disorders, such as hearing loss, mouth diseases, and throat cancers. Researchers will use leftover surgical tissue and additional samples like blood, saliva, and cheek swabs to study the…

This early-phase trial tests a fluorescent dye attached to the cancer drug panitumumab to help surgeons see head and neck cancer during surgery. 18 adults with head and neck squamous cell carcinoma will receive the dye before surgery, and a special camera will highlight cancer ti…

This study tests a high-resolution PET-CT scanner that images removed tumors right in the operating room. About 50 adults with solid cancers will get a standard PET tracer before surgery, then the removed tissue is scanned to see if all cancer was taken out. The goal is to see if…

This study looks at the forces applied to the tongue and throat during laryngeal surgery. Researchers will measure these forces in 100 adults and see if they relate to pain, numbness, or tongue movement after surgery. In the second half of the study, surgeons will see real-time f…

This study collects leftover tissue samples and additional blood, saliva, and cheek swabs from up to 1,000 people with hearing, balance, smell, taste, voice, or speech disorders. The samples are stored in a biobank for researchers to study the biology of these conditions. No new …