Intestinal infectious disease

This study tests a new vaccine (IP-QSV) designed to protect against four types of Shigella bacteria, which cause severe diarrhea. The trial will include 370 healthy adults, children, and infants in Mali. Researchers will check if the vaccine is safe and triggers a strong immune r…

This early-stage study tests a new oral cholera vaccine called DuoChol in 60 healthy adults aged 18 to 45 in Sweden. Participants will receive two doses of either DuoChol or an existing vaccine (Dukoral) to compare safety and immune response. The goal is to gather initial data to…

This study follows up on African children who received an experimental Shigella vaccine in earlier studies. Researchers will take blood samples 1, 2, and 3 years after the last vaccine dose to see how long the immune protection lasts. No new vaccines are given in this study. The …

This trial tests whether a single oral dose of ondansetron, a drug that curbs vomiting, can help children with cholera keep down oral rehydration solution (ORS). About 120 children aged 6 months to 17 years with suspected or confirmed cholera and active vomiting will receive eith…

This study looks at whether a special oral nutritional supplement, combined with dietary counseling, can improve growth in children who are not growing as expected. About 216 children will be randomly assigned to receive either the supplement plus counseling or counseling alone. …