Hypoparathyroidism

This phase 3 trial tests an oral drug called encaleret in about 160 adults with chronic hypoparathyroidism, a condition where the body makes too little parathyroid hormone, leading to low blood calcium and high urine calcium. Participants receive either encaleret or a placebo for…

This Phase 3 trial tests whether a once-weekly injection of canvuparatide (MBX 2109) can help adults with hypoparathyroidism reduce their daily calcium and vitamin D supplements while keeping blood calcium in a healthy range. The study includes 160 participants who will receive e…

This phase 3 trial tests higher daily doses (over 30 mcg) of palopegteriparatide (Yorvipath) in 36 adults with chronic hypoparathyroidism. Participants already on the drug will have their dose adjusted to find the best level for controlling calcium without needing extra vitamin D…

This study tests a daily injection called palopegteriparatide (Yorvipath) in adolescents aged 12 to 18 with chronic hypoparathyroidism, a condition where the body cannot regulate calcium levels. The goal is to see if the drug can safely bring calcium into the normal range while a…

This early-phase trial tests an mRNA drug called XH02 in 6 adults with hypoparathyroidism, a condition where the body lacks parathyroid hormone (PTH). The drug is designed to instruct cells to produce PTH after being given through a vein. The main goal is to check safety, while a…

This study tests an mRNA drug called XH-02 that helps the body produce parathyroid hormone (PTH) in adults with hypoparathyroidism, a condition where PTH levels are too low. The drug is given as a shot under the skin. The goal is to see if it safely improves calcium and phosphoru…

This study looks at whether taking a lower dose of calcium (twice a day) works as well as a higher dose (four times a day) to prevent low calcium symptoms in the two weeks after thyroid surgery. About 50 adults who develop mild low calcium after surgery will be split into two gro…

This study tests a simple injection of mashed parathyroid tissue into the forearm during thyroid surgery. The goal is to prevent permanent low calcium levels that require lifelong medication. About 100 adults having thyroid surgery will receive this injection, and researchers wil…

This early-stage trial tests an mRNA drug called XH-02 in 15 adults with hypoparathyroidism, a condition where the body doesn't make enough parathyroid hormone. The drug is injected under the skin to help replace the missing hormone and control calcium levels. The main goal is to…

This early-phase study tests whether transplanting donated parathyroid tissue into the forearm can help people with hypoparathyroidism achieve normal calcium and phosphorus levels. The trial enrolls 3 adults who have low parathyroid hormone after surgery. Participants will receiv…

This study tests a device called PTeye™ that uses near-infrared light to help surgeons see and protect tiny parathyroid glands during total thyroid removal. About 210 adults in Hong Kong will be randomly assigned to standard surgery or PTeye™-assisted surgery. The goal is to see …

This study tests whether using a special camera (autofluorescence imaging) during thyroid cancer surgery can lower the risk of hypoparathyroidism, a condition where the parathyroid glands stop working properly. About 160 adults having their thyroid removed will be randomly assign…

This study tests whether a device called PTeye, which uses near-infrared light to make parathyroid glands glow, helps surgeons find and protect these tiny glands during thyroid surgery. The trial will compare outcomes in 154 patients who have their first total thyroidectomy, with…

This study tests whether measuring parathyroid hormone (PTH) soon after thyroid removal can prevent symptomatic hypoparathyroidism, a condition causing low calcium and uncomfortable symptoms. About 336 adults having thyroid surgery will be monitored. If early PTH testing works, i…

This study tests whether using a special dye (indocyanine green) during total thyroidectomy helps surgeons see and protect the parathyroid glands, reducing the risk of permanent hypoparathyroidism. About 242 adults scheduled for total thyroid removal will be randomly assigned to …

This study reviews 10 years of medical records from 600 adults who had thyroid surgery at Minia University Hospital. The goal is to find out which patients are most likely to develop low calcium levels after surgery, a common complication. By identifying key risk factors, doctors…

This study looks at how much of the drug palopegteriparatide (YORVIPATH) gets into breast milk. It involves 10 women with hypoparathyroidism who are already taking the drug and breastfeeding. Researchers will collect milk samples to measure drug levels, helping understand safety …

This study follows 300 adults in Estonia who have their entire thyroid gland removed. The goal is to find out who is most likely to develop hypoparathyroidism—a condition where calcium levels drop after surgery—and whether low magnesium plays a role. Participants answer a questio…

This study is not testing a new drug or treatment. Instead, researchers want to make sure their lab tests and equipment give accurate and repeatable results when studying conditions like obesity, diabetes, heart disease, and bone loss. Up to 100 healthy volunteers and people with…

This registry study is collecting data from 50 women aged 15–50 who took YORVIPATH (palopegteriparatide) for hypoparathyroidism around the time of pregnancy or while breastfeeding. Researchers will monitor pregnancy complications, birth outcomes, and infant health through the fir…

This study follows 106 adults with hypoparathyroidism for three years to see how the disease affects organs like the kidneys and brain. Researchers will measure kidney function and look for calcium buildup in the kidneys and brain using optional CT scans. The goal is to better un…