Hydrocephalus

This program gives children with brain disorders like cerebral palsy or stroke access to umbilical cord blood infusions. The treatment uses donated cord blood cells to help repair brain damage. Kids up to age 26 with normal immune function may qualify. The goal is to improve symp…

This study looks at how safe and well a new adjustable valve system works for people with hydrocephalus, a condition where fluid builds up in the brain. About 126 patients will receive the valve to help drain excess fluid. The main goals are to see if the valve causes serious sid…

This study tests whether a special ultrasound with a contrast dye can safely and effectively measure brain health in infants with hydrocephalus, a condition where fluid builds up in the brain. About 20 infants under 1.5 years old will receive an injection of the contrast agent th…

This study is testing a small, wireless device that sticks to the skin over a shunt tube to see if fluid is flowing inside. It uses gentle warmth to measure temperature changes without breaking the skin. The trial includes 55 children and adults with hydrocephalus who already hav…

This study tests a new MRI technique to measure how cerebrospinal fluid flows in the brain. Researchers will compare 50 healthy volunteers and patients with conditions like Alzheimer's disease or normal pressure hydrocephalus. The goal is to improve diagnosis and understanding of…

This study follows 500 people with neurocysticercosis, a brain infection caused by the pork tapeworm. Participants receive standard antiparasitic drugs and anti-inflammatories. Researchers will track their health over many years to understand what factors lead to better or worse …

This study is testing a new device that aims to measure pressure inside the skull from the outside, avoiding the need for surgery. Currently, doctors must drill a hole in the skull to monitor intracranial pressure (ICP) in patients with conditions like traumatic brain injury or s…

This study tests a wearable device that measures fluid flow in cerebrospinal fluid shunts, which are used to treat hydrocephalus. Participants wear the device at home during normal activities and sleep to see if it can safely and reliably track shunt function. The goal is to deve…

This study looks at whether a standard dose of the antibiotic cefazolin, given before surgery to place a ventricular shunt, reaches high enough levels in the cerebrospinal fluid to prevent infection. Researchers will measure cefazolin in the fluid and blood of 15 adults undergoin…

This study looks at whether giving antibiotics for just 24 hours around the time of placing a special antibiotic-coated brain drain works as well as giving them for the whole time the drain is in place. The goal is to find the best way to prevent serious brain infections in peopl…

This study tests whether using ultrasound to guide placement of a brain drain (external ventricular drain) in adults with hydrocephalus can improve accuracy and reduce the number of needle passes needed. Ten participants will have the drain placed with the SOLOPASS® ultrasound sy…

This study looks at the best way to treat a fluid pocket (pseudomeningocele) that can form under the scalp after brain surgery. It compares doing nothing active (just watching and caring for the wound) with doing a procedure like draining the fluid or another surgery. The goal is…

This study is creating a large database of information about children with hydrocephalus (a condition where fluid builds up in the brain). Researchers will collect details on diagnosis, treatments, and outcomes from multiple hospitals. The goal is to better understand the disease…

This study follows 140 people with early signs of normal pressure hydrocephalus (NPH) to see if brain scans and fluid tests can predict who will get worse and need shunt surgery. Participants include those with mild symptoms, those with clear NPH, and healthy volunteers. The goal…

This study looks at whether certain proteins in spinal fluid can predict which adults with chronic hydrocephalus will improve after a shunt surgery. About 150 participants will have their fluid tested for amyloid and tau proteins, then tracked for changes in thinking, walking, an…

This study is gathering information from 4500 people who have or will have brain surgery for conditions like aneurysms, tumors, epilepsy, and Parkinson's disease. The goal is to find patterns that help doctors predict how well someone will recover. By standardizing how outcomes a…

This study looks at 100 older adults with normal pressure hydrocephalus (NPH) to find out why some get better after a shunt surgery and others do not. Researchers will use brain scans, blood tests, and wearable monitors to check for nerve damage and signs of dementia. The goal is…

This study tests a new wireless sensor called FlowSense, which is placed on the skin like a bandage to measure fluid flow in hydrocephalus patients with external drains. The goal is to see if it can accurately track drainage and pressure without needing X-rays or hospital equipme…

This study tests a non-invasive light-based device to measure blood flow and oxygen use in the brains of premature infants who have bleeding or fluid buildup. Researchers will compare these measurements in affected babies, those with other types of fluid buildup, and healthy newb…

This study is looking at 160 people who had a ruptured brain aneurysm and need a temporary drain. Researchers will measure glucose in their spinal fluid and blood daily for up to 14 days. The goal is to see if higher glucose levels are linked to needing a permanent shunt later. P…

This study watches 148 adults with acute brain injury who have a drain in their head. Researchers will check fluid from the brain to see if changes in a substance called lactate can signal an infection early. The goal is to learn more, not to test a new treatment.