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Hereditary spastic paraplegia

MONDO:0019064

Hereditary spastic paraplegias (HSP) comprise a genetically and clinically heterogeneous group of neurodegenerative disorders characterized by progressive spasticity and hyperreflexia of the lower limbs.

Also known as: spastic paraplegia, HSP, SPG, Strümpell-Lorrain disease, familial spastic paraplegia, hereditary spastic paraparesis, FSP, familial spastic paraparesis

33 clinical trials for this condition and its sub-types, 27 tagged with Hereditary spastic paraplegia itself.

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Where it sits in the disease tree

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Part of

↑ Hereditary neuromuscular disease (932) ↑ Inherited neurodegenerative disorder (807) ↑ Paraplegia (68)

Sub-types of Hereditary spastic paraplegia

Complex hereditary spastic paraplegia 1 trial · 7 incl. sub-types
50 sub-types
- Spastic paraplegia, optic atropy, and neuropathy 3 trials
- Hereditary spastic paraplegia 11 1 trial
- Hereditary spastic paraplegia 15 1 trial
- Hereditary spastic paraplegia 26 1 trial
- Hereditary spastic paraplegia 63 1 trial
- MASA syndrome 0 trials
- Troyer syndrome 0 trials
- Autosomal dominant complex spastic paraplegia 0 trials Sub-types →
- Autosomal recessive complex spastic paraplegia due to kennedy pathway dysfunction 0 trials
- Autosomal recessive complex spastic paraplegia type 9B 0 trials
- Autosomal recessive spastic paraplegia type 59 0 trials
- Autosomal recessive spastic paraplegia type 60 0 trials
- Autosomal recessive spastic paraplegia type 66 0 trials
- Autosomal recessive spastic paraplegia type 67 0 trials
- Autosomal recessive spastic paraplegia type 68 0 trials
- Autosomal recessive spastic paraplegia type 69 0 trials
- Autosomal recessive spastic paraplegia type 70 0 trials
- Autosomal recessive spastic paraplegia type 76 0 trials
- Autosomal recessive spastic paraplegia type 78 0 trials
- Fatty acid hydroxylase-associated neurodegeneration 0 trials
- Glutamate pyruvate transaminase 2 deficiency 0 trials
- Hereditary sensory and autonomic neuropathy with spastic paraplegia 0 trials
- Hereditary spastic paraplegia 18 0 trials Sub-types →
- Hereditary spastic paraplegia 23 0 trials
- Hereditary spastic paraplegia 24 0 trials
- Hereditary spastic paraplegia 25 0 trials
- Hereditary spastic paraplegia 27 0 trials
- Hereditary spastic paraplegia 32 0 trials
- Hereditary spastic paraplegia 39 0 trials Sub-types →
- Hereditary spastic paraplegia 43 0 trials
- Hereditary spastic paraplegia 44 0 trials
- Hereditary spastic paraplegia 45 0 trials
- Hereditary spastic paraplegia 46 0 trials
- Hereditary spastic paraplegia 49 0 trials
- Hereditary spastic paraplegia 53 0 trials
- Hereditary spastic paraplegia 54 0 trials
- Hereditary spastic paraplegia 55 0 trials
- Hereditary spastic paraplegia 57 0 trials
- Hereditary spastic paraplegia 61 0 trials
- Hereditary spastic paraplegia 64 0 trials
- Hereditary spastic paraplegia 74 0 trials
- Hereditary spastic paraplegia 75 0 trials
- Kyphoscoliosis-lateral tongue atrophy-hereditary spastic paraplegia syndrome 0 trials
- Maternally-inherited spastic paraplegia 0 trials
- Spastic ataxia 2 0 trials
- Spastic paraplegia 84, autosomal recessive 0 trials
- Spastic paraplegia 85, autosomal recessive 0 trials
- Spastic paraplegia 86, autosomal recessive 0 trials
- Spastic paraplegia-glaucoma-intellectual disability syndrome 0 trials
- Spastic paraplegia-severe developmental delay-epilepsy syndrome 0 trials
Hereditary spastic paraplegia 50 3 trials
Hereditary spastic paraplegia 3A 2 trials
Hereditary spastic paraplegia 4 2 trials
Hereditary spastic paraplegia 5A 2 trials
Hereditary spastic paraplegia 47 1 trial
Hereditary spastic paraplegia 51 1 trial
Hereditary spastic paraplegia 52 1 trial
Hereditary spastic paraplegia 7 1 trial
ADAR-related hereditary spastic paraplegia 0 trials
Charcot-Marie-Tooth disease type 5 0 trials
IFIH1-related hereditary spastic paraplegia 0 trials
RNASEH2B-related hereditary spastic paraplegia 0 trials
Early-onset progressive neurodegeneration-blindness-ataxia-spasticity syndrome 0 trials
Hereditary spastic paraplegia 10 0 trials
Hereditary spastic paraplegia 13 0 trials
Hereditary spastic paraplegia 14 0 trials
Hereditary spastic paraplegia 16 0 trials
Hereditary spastic paraplegia 2 0 trials
Hereditary spastic paraplegia 30 0 trials
2 sub-types
- Spastic paraplegia 30A, autosomal dominant 0 trials
- Spastic paraplegia 30B, autosomal recessive 0 trials
Hereditary spastic paraplegia 31 0 trials
Hereditary spastic paraplegia 33 0 trials
Hereditary spastic paraplegia 35 0 trials
Hereditary spastic paraplegia 48 0 trials
Hereditary spastic paraplegia 56 0 trials
Hereditary spastic paraplegia 6 0 trials
Hereditary spastic paraplegia 77 0 trials
Macrocephaly-spastic paraplegia-dysmorphism syndrome 0 trials
Mast syndrome 0 trials
Pure hereditary spastic paraplegia 0 trials
12 sub-types
- Autosomal recessive spastic paraplegia type 71 0 trials
- Hereditary spastic paraplegia 12 0 trials
- Hereditary spastic paraplegia 19 0 trials
- Hereditary spastic paraplegia 28 0 trials
- Hereditary spastic paraplegia 34 0 trials
- Hereditary spastic paraplegia 37 0 trials
- Hereditary spastic paraplegia 41 0 trials
- Hereditary spastic paraplegia 42 0 trials
- Hereditary spastic paraplegia 62 0 trials
- Hereditary spastic paraplegia 72 0 trials
- Hereditary spastic paraplegia 73 0 trials
- Hereditary spastic paraplegia 8 0 trials
Pure or complex hereditary spastic paraplegia 0 trials
Spastic paraplegia 72b, autosomal recessive 0 trials
Spastic paraplegia 79A, autosomal dominant, with ataxia 0 trials
Spastic paraplegia 80, autosomal dominant 0 trials
Spastic paraplegia 81, autosomal recessive 0 trials
Spastic paraplegia 82, autosomal recessive 0 trials
Spastic paraplegia 83, autosomal recessive 0 trials
Spastic paraplegia 87, autosomal recessive 0 trials
Spastic paraplegia 88, autosomal dominant 0 trials
Spastic paraplegia 89, autosomal recessive 0 trials
Spastic paraplegia 90A, autosomal dominant 0 trials
Spastic paraplegia 90B, autosomal recessive 0 trials
Spastic paraplegia 91, autosomal dominant, with or without cerebellar ataxia 0 trials
Spastic paraplegia 92, autosomal recessive 0 trials
Spastic paraplegia 93, autosomal recessive 0 trials

Most studied deeper sub-types

Autosomal dominant complex spastic paraplegia type 9B (0) Autosomal dominant spastic paraplegia type 9 (0) Hereditary spastic paraplegia 17 (0) Hereditary spastic paraplegia 29 (0) Hereditary spastic paraplegia 36 (0) Hereditary spastic paraplegia 38 (0) Hereditary spastic paraplegia 9A (0) PNPLA6-related spastic paraplegia with or without ataxia (0) Spastic paraplegia 18a, autosomal dominant (0) Spastic paraplegia 18b, autosomal recessive (0) Spastic paraplegia-epilepsy-intellectual disability syndrome (0) Spastic paraplegia-facial-cutaneous lesions syndrome (0) Spastic paraplegia, intellectual disability, nystagmus, and obesity (0) Spastic paraplegia-nephritis-deafness syndrome (0) Spastic paraplegia-neuropathy-poikiloderma syndrome (0) Spastic paraplegia-Paget disease of bone syndrome (0) Spastic paraplegia-precocious puberty syndrome (0)

Including sub-types (33) Tagged with Hereditary spastic paraplegia (27)

Trials to join now! 14 Not yet finished but already full! 7 Completed 10 Terminated 2