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Hereditary palmoplantar keratoderma
MONDO:0019272An instance of palmoplantar keratosis that is caused by an inherited modification of the individual's genome.
Also known as: hereditary PPK, hereditary keratosis palmoplantaris, hereditary palmoplantar hyperkeratosis, hereditary palmoplantar keratosis
13 clinical trials for this condition and its sub-types, 0 tagged with Hereditary palmoplantar keratoderma itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Sub-types of Hereditary palmoplantar keratoderma
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Diffuse palmoplantar keratoderma 0 trials · 12 incl. sub-types
32 sub-types
- Papillon-Lefevre disease 5 trials
- Corneal intraepithelial dyskeratosis-palmoplantar hyperkeratosis-laryngeal dyskeratosis syndrome 4 trials
- Odonto-onycho-dermal dysplasia 2 trials
- Epidermolytic palmoplantar keratoderma, 1 1 trial
- Bart-Pumphrey syndrome 0 trials
- CEDNIK syndrome 0 trials
- Clouston syndrome 0 trials
- Curly hair - acral keratoderma - caries syndrome 0 trials
- Haim-Munk syndrome 0 trials
- KID syndrome 0 trials Sub-types →
- Naegeli-Franceschetti-Jadassohn syndrome 0 trials
- Schöpf-Schulz-Passarge syndrome 0 trials
- Autosomal dominant palmoplantar keratoderma and congenital alopecia 0 trials
- Autosomal recessive palmoplantar keratoderma and congenital alopecia 0 trials
- Dermatopathia pigmentosa reticularis 0 trials
- Diffuse nonepidermolytic palmoplantar keratoderma 0 trials
- Diffuse palmoplantar keratoderma - acrocyanosis syndrome 0 trials
- Diffuse palmoplantar keratoderma with painful fissures 0 trials
- Erythrokeratodermia variabilis 0 trials Sub-types →
- Hearing loss with skin disease 0 trials
- Hereditary palmoplantar keratoderma, Gamborg-Nielsen type 0 trials
- Hypohidrosis-enamel hypoplasia-palmoplantar keratoderma-intellectual disability syndrome 0 trials
- Keratosis palmaris et plantaris-clinodactyly syndrome 0 trials
- Loricrin keratoderma 0 trials
- Mal de Meleda 0 trials
- Palmoplantar keratoderma, Bothnian type 0 trials
- Palmoplantar keratoderma, Nagashima type 0 trials
- Palmoplantar keratoderma-XX sex reversal-predisposition to squamous cell carcinoma syndrome 0 trials
- Palmoplantar keratoderma-deafness syndrome 0 trials
- Palmoplantar keratoderma-hereditary motor and sensory neuropathy syndrome 0 trials Sub-types →
- Palmoplantar keratoderma-sclerodactyly syndrome 0 trials
- Skin fragility-woolly hair-palmoplantar keratoderma syndrome 0 trials
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Olmsted syndrome 1 trial
3 sub-types
- Olmsted syndrome 1 0 trials
- Olmsted syndrome 2 0 trials
- Olmsted syndrome, X-linked 0 trials
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Focal palmoplantar keratoderma 0 trials · 1 incl. sub-types
12 sub-types
- Pachyonychia congenita 1 trial Sub-types →
- Focal palmoplantar and gingival keratoderma 0 trials
- Focal palmoplantar keratoderma with joint keratoses 0 trials
- Hereditary painful callosities 0 trials
- Hypotrichosis-osteolysis-periodontitis-palmoplantar keratoderma syndrome 0 trials
- Isolated focal non-epidermolytic palmoplantar keratoderma 0 trials
- Nail and teeth abnormalities-marginal palmoplantar keratoderma-oral hyperpigmentation syndrome 0 trials
- Palmoplantar keratoderma, nonepidermolytic, focal 1 0 trials
- Palmoplantar keratoderma-esophageal carcinoma syndrome 0 trials
- Striate palmoplantar keratoderma 0 trials Sub-types →
- Tyrosinemia type II 0 trials
- Wooly hair-palmoplantar keratoderma syndrome 0 trials
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Palmoplantar keratoderma, epidermolytic 0 trials · 1 incl. sub-types
2 sub-types
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Punctate palmoplantar keratoderma 0 trials
4 sub-types
- Focal acral hyperkeratosis 0 trials
- Punctate palmoplantar keratoderma type 1 0 trials Sub-types →
- Punctate palmoplantar keratoderma type 2 0 trials
- Punctate palmoplantar keratoderma type III 0 trials
Most studied deeper sub-types
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Half the dose, same hope? trial tests cutting hormone therapy in prostate cancer
Disease control Recruiting nowThis phase 3 trial is testing whether giving men with metastatic prostate cancer half the standard dose of certain hormone therapies (called ARPIs) can be just as effective as the full dose, while causing less fatigue and fewer treatment stoppages. About 1,500 men with prostate c…
Phase 3 • Sponsor: University College, London • Aim: Disease control
Last updated Sep 06, 2026 00:00 UTC
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New combo aims to keep prostate cancer in check with lower chemo dose
Disease control Recruiting nowThis study tests a combination of darolutamide, hormone therapy, and a lower dose of the chemotherapy drug docetaxel in men with metastatic hormone-sensitive prostate cancer. The goal is to see if this approach can keep PSA levels very low (below 0.2 ng/mL) at 24 weeks while redu…
Phase 2 • Sponsor: Yonghong Li • Aim: Disease control
Last updated Sep 02, 2026 00:00 UTC
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New pill could ease rare skin disease
Disease control Recruiting nowThis early-stage trial tests an oral drug called KM-023 for Olmsted Syndrome, a rare genetic condition causing painful, thick skin on the palms and soles. First, healthy volunteers will receive single or multiple doses to check safety and how the body handles the drug. Then, pati…
Phase 1 • Sponsor: Orvida Pharma (formerly Kamari Pharma) • Aim: Disease control
Last updated Jun 27, 2026 12:36 UTC
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Can advanced imaging reveal hidden swallowing muscle damage in IBM?
Diagnosis Recruiting nowResearchers at Johns Hopkins University are studying whether neuromuscular ultrasound and MRI can serve as reliable markers of swallowing muscle problems in people with inclusion body myositis (IBM). The study compares imaging and clinical findings in 30 participants, including p…
Sponsor: Johns Hopkins University • Aim: Diagnosis
Last updated Sep 18, 2026 00:00 UTC
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Better smiles with 3D printing? new study tests dentures for rare condition
Symptom relief Recruiting nowThis study looks at whether 3D-printed dentures fit better and make patients happier than traditional acrylic dentures in people with ectodermal dysplasia, a rare condition that affects teeth and other body parts. About 11 people aged 10 to 35 who have some remaining teeth will t…
Sponsor: Cairo University • Aim: Symptom relief
Last updated Jun 27, 2026 11:00 UTC
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Massive data bank launched to unlock secrets of ALS and motor neuron diseases
Knowledge-focused Recruiting nowThis study is building a large database of health information from 5,000 people with ALS and other motor neuron diseases. Participants share details like symptoms, test results, and disease progression during regular clinic visits. The de-identified data is then shared with resea…
Sponsor: Massachusetts General Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:35 UTC
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New study to measure hidden toll of rare skin diseases on patients and families
Knowledge-focused Recruiting nowThis study aims to understand the full burden of 9 rare skin diseases—including physical, emotional, social, and financial challenges—on patients and their families. Researchers will use special questionnaires to track how these conditions affect daily life and care needs. About …
Sponsor: Institut National de la Santé Et de la Recherche Médicale, France • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:04 UTC