Heart valve disorder

This trial tests whether empagliflozin, a drug already used for diabetes and heart failure, can prevent the heart muscle from thickening or developing fibrosis in people with moderate aortic stenosis. Participants will receive either empagliflozin or standard care for six months,…

This trial tests whether a prehabilitation program — including exercise, education, and breathing techniques — helps people recover faster after planned heart surgery. The study enrolls adults scheduled for surgery for coronary artery disease, valve problems, or other heart condi…

This study looked at ways to help children aged 5-20 with rheumatic heart disease take their regular antibiotics. Researchers compared having a case manager alone versus a case manager plus a peer support group. The goal was to see if the simpler approach works just as well to ke…

This study tested a new tool called TELLTALE designed to safely cut a heart tissue flap during a valve replacement procedure (TAVR). In some cases, this flap can block blood flow to the heart, which is often fatal. The trial involved 90 adults at high risk of this complication. R…

This study tested a virtual cardiac rehabilitation program using a smartphone app, a fitness wristband, and a blood pressure monitor for people who recently had a heart attack, heart surgery, or a stent. The goal was to see if this home-based program could improve walking ability…

This study looked at how safe and effective Abbott's Regent mechanical heart valve is for Chinese patients needing a new aortic valve. Researchers followed 200 adults who received the valve to track valve-related deaths and the need for repeat surgery. The goal was to confirm the…

This study tested a device called MitraClip, which is a small clip placed through a tube in a vein to repair a leaky mitral valve in the heart. The trial included 304 people with severe mitral regurgitation and heart failure. Half got the clip plus standard medical care, and half…

This trial evaluates an artificial intelligence algorithm, AutoAS, that analyzes ultrasound images of the heart to detect aortic stenosis — a narrowing of the heart's main valve. Researchers will collect images from adults scheduled for a standard echocardiogram and test how well…

This study tested a drug called conestat alfa in 141 people undergoing a minimally invasive heart valve replacement (TAVI) for severe aortic stenosis. The goal was to see if the drug could reduce the risk of small strokes and kidney damage that can happen after the procedure. Par…

Researchers are testing whether a hybrid cardiac rehabilitation programme can help adults recover after heart surgery. Participants start with two weeks of supervised exercise at the hospital, then continue training at home for six weeks using heart-rate monitors, a cloud care pl…

This trial tests whether a stellate ganglion block—an injection near a nerve cluster in the neck—can help people recover faster after heart valve replacement surgery. Half of the 62 participants receive the block with a numbing medication, while the other half gets a placebo. Res…

This pilot trial tests a technique called cryoanalgesia, which uses extreme cold to temporarily freeze nerves in the chest during heart surgery. The goal is to block pain signals, potentially reducing the need for opioid painkillers and improving recovery. The study enrolls adult…

This study tested whether a specific nerve block, called SPSIPB, can reduce pain and the need for strong painkillers after minimally invasive heart surgery. Fifty adults were split into two groups: one got the nerve block plus standard care, the other got standard care alone. Res…

This study looked at whether a short virtual reality mindfulness session could help patients feel less anxious and stressed after heart surgery. 34 adults who had heart bypass or valve repair took part. One group did a 15-minute VR mindfulness exercise, while the other group rece…

This study tested whether special nerve blocks (fascial plane blocks) can improve pain control and reduce time on a breathing machine after open-heart surgery. 206 adults having heart surgery were divided into two groups: one received the nerve blocks plus standard pain care, the…

This study tested whether adding dexmedetomidine to a standard numbing medicine (bupivacaine) in chest nerve blocks could provide better pain relief after heart surgery. Sixty adults having open-heart surgery through a chest incision received the nerve block with or without the e…

This study tested whether virtual reality relaxation or binaural beat stimulation can improve sleep and reduce discomfort in 140 adults who had mechanical heart valve replacement. Many patients struggle with sleep due to the sound of the new valve. Participants were randomly assi…

This study tested whether a nerve block called erector spinae plane block (ESPB) can improve pain control and recovery in adults undergoing open-heart surgery. Sixty-six participants received either the nerve block or standard IV opioids. Researchers measured pain scores, need fo…

This study tested a combination of brain monitoring and specific drugs during heart surgery to see if it could reduce confusion, pain, and blood pressure problems afterward. 70 older adults (60+) having heart bypass or valve surgery took part. The approach used EEG monitoring and…

This study tested whether a nursing approach based on Kolcaba's comfort theory can improve comfort and reduce pain in adults recovering from open heart valve surgery. Fifty-six patients were randomly assigned to receive either standard care or comfort-focused nursing. Their comfo…

This study looked at whether having a nurse talk with patients before and after a heart valve procedure could improve care. About 194 people took part. The nurses helped prepare patients and checked on them afterward, either by phone or in person. The goal was to see if this extr…

This study tested whether Reiki (a light-touch energy therapy) and manual therapy (gentle massage) can improve recovery after open heart surgery. 272 patients were randomly assigned to receive either 20 minutes of these therapies for 3 days after surgery, or usual care with rest.…

This study analyzed health records from over 400,000 adults who had heart surgery to see if the sedative dexmedetomidine helped prevent problems like confusion, kidney injury, or death within 30 days. Researchers compared patients who received the drug around surgery time to thos…

This study tests a hospital-wide treatment guide for people with heart failure and a leaky mitral valve (secondary mitral regurgitation). The goal is to see if the guide helps doctors identify which patients will benefit most from a minimally invasive valve repair procedure calle…

This study follows 200 adults who have elective coronary bypass or heart valve surgery to see how their physical abilities, lung function, and muscle strength change after the operation. Researchers measure walking speed, balance, handgrip strength, and breathing tests before and…

This study looked at whether using a very low flow of the anesthesia gas sevoflurane during heart surgery is safe and reduces environmental impact. 92 adults having planned heart surgery were randomly assigned to receive either ultra-low-flow or normal-flow anesthesia. Researcher…

This completed study looked at whether four easy-to-use nutrition scoring tools (GNRI, MNA-SF, PNI, and NAF) can predict serious lung complications after heart surgery in 217 patients aged 60 and older. Researchers tracked problems like pneumonia, blood clots in the lungs, and ne…

This study tested a simple flowchart to help doctors monitor and manage heart conduction problems after transcatheter aortic valve replacement (TAVR). The goal was to see if this approach could safely reduce the need for intensive care and permanent pacemakers. Researchers follow…

This completed study observed 528 adults who had heart surgery and were admitted to the intensive care unit (ICU). Researchers tracked deaths, serious complications like stroke or infection, and patient details to identify risk factors. The goal is to use this information to impr…

This study looked back at records of 200 adults who had heart valve surgery to see if treating gum disease beforehand lowered their risk of infection or death after the operation. Researchers checked dental X-rays and medical charts from 2015 to 2024. The goal is to understand if…

This study looks at whether bacteria living on heart valves can be detected in the blood. Researchers collected blood, valve tissue, and other samples from 100 patients having aortic valve replacement. The goal is to see if a simple blood test could guide treatment and predict co…

This study looked at how certain natural chemicals in the body affect recovery after heart surgery. Researchers followed 287 adults having open-heart surgery to see if these chemicals are linked to problems like confusion after the operation. The goal was to better understand the…

This study looked at 1,811 patients aged 60-70 who had heart valve replacement surgery. Researchers compared different types of artificial valves to see if the valve type was linked to developing depression, anxiety, or sleep disorders later. The goal was to understand if the cho…

This completed study used artificial intelligence to analyze electrocardiograms (ECGs) and chest X-rays from over 116,000 adults. The goal was to see if combining these routine tests could predict which patients would develop moderate or severe heart valve regurgitation. The rese…

This study looked at 80 adults having heart valve or aortic surgery to find out how long a special heart protection solution (Del Nido cardioplegia) keeps the heart safe during surgery. Researchers took blood samples at set times to see when heart injury began. The goal was to le…

This study looked at two ways to manage breathing during heart surgery that requires one lung to be deflated. Researchers compared using a double-lumen tube versus a bronchial blocker in 66 patients. They checked for lung problems after surgery, how long it took to place the devi…

This study looked at 1,444 adults who had heart valve replacement using a heart-lung machine. Researchers wanted to see if spending more than 120 minutes on the machine raised the chance of gut complications. They compared patients with shorter and longer bypass times and tracked…

This study tested a computer program called naevia medical that helps doctors decide the best treatment for heart valve disease. Researchers looked at 106 past patient cases to see if the tool gave better recommendations than usual care. The goal was to see if the tool could redu…

This study looked at 348 people who had open heart surgery with a heart-lung machine. Researchers wanted to see if the ratio of time on the machine to time the heart was stopped affected complications or death. The goal is to find a better way to predict and improve recovery afte…

This completed study looked at whether removing extra water from the blood just before taking patients off the heart-lung machine could improve blood clotting. It included 39 adults having heart valve surgery. The researchers measured changes in clot strength using a special bloo…