Heart surgery gut risk: longer bypass time may raise complications
NCT ID NCT06697405
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study looked at 1,444 adults who had heart valve replacement using a heart-lung machine. Researchers wanted to see if spending more than 120 minutes on the machine raised the chance of gut complications. They compared patients with shorter and longer bypass times and tracked gut issues like bowel function and injury scores. The goal is to better understand risks and improve recovery after surgery.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- What this could lead to
- If it succeeds, this could help doctors identify patients at higher risk for gut problems after heart valve surgery and improve recovery care.
- What could go wrong
- This is a retrospective study, so it can only show links, not cause and effect. Results may not apply to all patients or hospitals.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Participants
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1,444 people
The number who actually took part.
- Started
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Dec 2024
- Finished
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Dec 2025
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
Patients undergoing heart valve replacement with differ CPB durations.
- Ages
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18 to 75 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Patients undergoing heart valve replacement with CPB * Age ≥ 18 years and ≤ 75 years Exclusion Criteria: * Have received major gastrointestinal surgery within 5 years. * History of severe infection (e.g., pneumonia, urinary tract infection) requiring hospitalization within 1 month prior to surgery. * Inflammatory bowel disease (IBD), including ulcerative colitis, Crohn's disease, or colitis. * Acute gastroenteritis. * Clostridium difficile or Helicobacter pylori infection. * Chronic constipation. * Peptic ulcer. * Polyps in the stomach or intestines. * Gastrointestinal neoplasms. * Abdominal hernia. * Irritable bowel syndrome. * Acute or chronic cholecystitis, hepatitis. * Patients who died intraoperatively or within 24 hours postoperatively. * Patients with digestive system tumors. * Pregnancy or breastfeeding could affect postoperative medication use and study observations. * Involvement in other studies that may interfere with the objective results of this study.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Hepatopancreatobiliary Surgery Institute of Gansu Province
Lanzhou, Gansu, 730000, China
More trials for these conditions
Other studies related to the condition(s) this trial covers.