Gout

This study compares two ways of managing gout: a supported self-management approach where patients monitor their own urate levels with a finger-prick test and adjust medication via a smartphone app, versus usual care where a doctor manages treatment. The goal is to see if the sel…

This Phase 3 trial tests whether a new drug, tigulixostat, is better than the standard gout medication febuxostat at lowering uric acid levels in Chinese adults with gout. About 600 participants will take one of the two drugs for 24 weeks, then switch to tigulixostat for another …

This study tests a new medicine called AR882 to see if it can lower uric acid levels in people with gout. About 750 adults with gout will receive either AR882 or a placebo for 12 months. The main goal is to see if AR882 helps more patients reach a safe uric acid level and reduce …

This early-stage trial is testing a new oral drug called F-02-2-Na in 69 adults with high uric acid levels, with or without gout. The main goal is to check the drug's safety and how the body processes it at different doses. Participants will receive either the drug or a placebo, …

This study tests a new drug called AR882, taken with a standard gout medication (XOI), in 15 people with severe, uncontrolled gout who have already failed uricase therapy. The goal is to see if the combination can lower uric acid levels and shrink painful uric acid crystal deposi…

This trial tests an AI chatbot called Gout Buddy that gives personalized diet advice to people with gout. 110 participants will either use the chatbot or receive standard care. The goal is to see if the chatbot improves dietary knowledge, eating habits, medication adherence, and …

This study tests whether a culturally tailored storytelling video, shown on a tablet, can help 200 gout patients—especially African Americans in the Southeast—better understand their condition and stick with long-term treatments like medication, diet, and exercise. The goal is to…

This study tests whether regular email communication between gout patients and their doctors can help lower uric acid levels more effectively than standard care. 204 adults with confirmed gout will either follow usual care or use a secure messaging system to adjust their medicati…

This study tests whether a pharmacist-led program can help people reduce their risk of heart disease. Over 1,000 adults with conditions like diabetes, high blood pressure, or obesity are taking part. Pharmacists use a step-by-step guide to assess risk and support lifestyle change…

This early-stage study tests a single dose of a new antibody injection in 64 people. Part A includes healthy volunteers to check safety, and Part B includes people with an acute gout flare. The main goal is to see if the drug is safe and how the body processes it.

This study tests if anakinra is better than prednisone for treating gout flares in people with advanced chronic kidney disease or who have had a kidney transplant. Gout causes sudden, severe joint pain. Standard treatments can be risky for these patients. The study measures pain …

This study looked at whether people who donate a kidney have a higher chance of developing gout later in life compared to similar healthy people who did not donate. Researchers reviewed health records from 50,000 donors and matched non-donors in Canada over many years. The goal i…

This study will use a special blood test called mass spectrometry to look at immune cells in 500 people with various autoimmune diseases and healthy volunteers. The goal is to find patterns that could help doctors diagnose these conditions sooner. No treatments are being tested; …

This early-stage trial is testing a new drug called F-02-2-Na, designed to lower uric acid levels in people with gout or high uric acid. The study will give 12 healthy adults a single dose of the drug, once on an empty stomach and once after a meal, to see if food changes how the…

This study planned to use a machine learning algorithm to estimate blood potassium levels from a single-lead ECG in hospitalized patients. It was designed as a retrospective analysis of existing data from a home hospital program. However, the study was withdrawn before enrolling …

This study aimed to see if a computer could learn to predict how long a patient would stay in a home hospital program. Researchers planned to use data from past patients to train the computer. However, the study was withdrawn before any patients were enrolled, so no results are a…

This study is a review of many smaller trials that looked at what happens when people replace animal protein (like meat, dairy, eggs) with plant protein (like beans, nuts, seeds). The goal is to see if this simple swap can improve blood sugar, cholesterol, blood pressure, weight,…

This study follows 21 people with high uric acid but no gout symptoms for up to 5 years. Researchers use ultrasound and CT scans to look for tiny crystal deposits in joints. The goal is to see if these deposits can predict who will later develop painful gout flares.

This study follows 50 adults with tophaceous gout who are starting or adjusting urate-lowering therapy. Researchers use a special CT scan (Dual-Energy CT) to measure how much the uric acid crystals in tophi shrink after 6 and 12 months of treatment. They also check whether bone e…