New CT scan reveals how gout treatments melt crystal deposits
NCT ID NCT03965676
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This study follows 50 adults with tophaceous gout who are starting or adjusting urate-lowering therapy. Researchers use a special CT scan (Dual-Energy CT) to measure how much the uric acid crystals in tophi shrink after 6 and 12 months of treatment. They also check whether bone erosions heal as the tophi get smaller. The goal is to better understand why some tophi dissolve faster than others and which locations respond best.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- urate-lowering therapy
- What this could lead to
- If successful, this could help doctors predict which gout patients will respond best to treatment and whether tophus shrinkage can repair bone damage.
- What could go wrong
- This is a small observational study (50 people) with no control group, so results may not apply broadly. It measures imaging changes, not direct patient outcomes like pain or quality of life.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 50 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Jul 2019
- Expected to finish
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Oct 2025
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 100 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Age greater than or equal to 18 years * Patient with a tophaceous gout * Without urate-lowering treatment or with treatment but uricemia not at target * Having given its free and informed consent to participate in this study * Affiliated with a social security system Exclusion Criteria: * Pregnant or breastfeeding woman * Participation in another intervention research or period of exclusion due to a previous research. * Impossibility to position oneself in ventral position (position for hands/wrists DECT acquisition).
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Radiology Department Lariboisière Hospital
Paris, Île-de-France Region, 75010, France
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Reumatology Department Lariboisière Hospital
Paris, Île-de-France Region, 75010, France
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