Germ cell tumor
MONDO:0005040A benign or malignant, gonadal or extragonadal neoplasm that originates from germ cells. Representative examples include teratoma, seminoma, embryonal carcinoma, and yolk sac tumor.
Also known as: germ cell neoplasm, germ cell tumor, neoplasm of germ cell, neoplasm of the germ cell, tumor of germ cell, tumor of the germ cell, tumour of germ cell, tumour of the germ cell
1542 clinical trials for this condition and its sub-types, 57 tagged with Germ cell tumor itself.
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Sub-types of Germ cell tumor
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Malignant germ cell tumor 14 trials · 70 incl. sub-types
13 sub-types
- Malignant testicular germ cell tumor 14 trials · 36 incl. sub-types Sub-types →
- Extragonadal germ cell cancer 0 trials · 22 incl. sub-types Sub-types →
- Seminoma 22 trials Sub-types →
- Germinoma 7 trials · 9 incl. sub-types Sub-types →
- Mixed germ cell tumor 3 trials · 5 incl. sub-types Sub-types →
- Malignant germ cell tumor of ovary 2 trials · 4 incl. sub-types Sub-types →
- Malignant childhood germ cell neoplasm 0 trials · 3 incl. sub-types Sub-types →
- Malignant teratoma 1 trial · 3 incl. sub-types Sub-types →
- Dysgerminoma 1 trial Sub-types →
- Malignant germ cell tumor of cervix uteri 0 trials
- Malignant germ cell tumor of corpus uteri 0 trials Sub-types →
- Pulmonary artery choriocarcinoma 0 trials
- Vaginal germ cell malignant tumor 0 trials Sub-types →
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Gonadal germ cell tumor 0 trials · 52 incl. sub-types
3 sub-types
- Testicular germ cell tumor 13 trials · 49 incl. sub-types Sub-types →
- Malignant germ cell tumor of ovary 2 trials · 4 incl. sub-types Sub-types →
- Childhood gonadal germ cell tumor 1 trial · 2 incl. sub-types Sub-types →
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Nongerminomatous germ cell tumor 12 trials · 33 incl. sub-types
3 sub-types
- Extragonadal non-dysgerminomatous germ cell tumor 0 trials · 21 incl. sub-types Sub-types →
- Teratoma 6 trials · 10 incl. sub-types Sub-types →
- Malignant non-dysgerminomatous germ cell tumor of ovary 1 trial · 2 incl. sub-types Sub-types →
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Extragonadal germ cell tumor 2 trials · 29 incl. sub-types
6 sub-types
- Extragonadal germ cell cancer 0 trials · 22 incl. sub-types Sub-types →
- Extragonadal non-dysgerminomatous germ cell tumor 0 trials · 21 incl. sub-types Sub-types →
- Central nervous system germ cell tumor 6 trials · 9 incl. sub-types Sub-types →
- Mediastinal germ cell tumor 0 trials · 2 incl. sub-types Sub-types →
- Cardiac germ cell tumor 0 trials Sub-types →
- Lung germ cell tumor 0 trials
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Germinomatous germ cell tumor 1 trial · 22 incl. sub-types
2 sub-types
- Seminoma 22 trials Sub-types →
- Dysgerminoma 1 trial Sub-types →
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Ovarian germ cell tumor 9 trials · 13 incl. sub-types
4 sub-types
- Malignant germ cell tumor of ovary 2 trials · 4 incl. sub-types Sub-types →
- Ovarian teratoma 0 trials · 3 incl. sub-types Sub-types →
- Pediatric ovarian germ cell tumor 0 trials · 2 incl. sub-types Sub-types →
- Ovarian cystic teratoma 0 trials Sub-types →
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Childhood germ cell tumor 3 trials · 7 incl. sub-types
4 sub-types
- Malignant childhood germ cell neoplasm 0 trials · 3 incl. sub-types Sub-types →
- Childhood central nervous system germ cell tumor 0 trials · 2 incl. sub-types Sub-types →
- Childhood gonadal germ cell tumor 1 trial · 2 incl. sub-types Sub-types →
- Pediatric ovarian germ cell tumor 0 trials · 2 incl. sub-types Sub-types →
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Choriocarcinoma 4 trials · 5 incl. sub-types
8 sub-types
- Choriocarcinoma of ovary 1 trial Sub-types →
- Choriocarcinoma of testis 1 trial Sub-types →
- Gestational choriocarcinoma 0 trials · 1 incl. sub-types Sub-types →
- Choriocarcinoma of the central nervous system 0 trials Sub-types →
- Gastric choriocarcinoma 0 trials
- Non-gestational choriocarcinoma 0 trials
- Placental site trophoblastic tumor 0 trials
- Pulmonary artery choriocarcinoma 0 trials
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Adult germ cell tumor 0 trials
3 sub-types
- Adult central nervous system germ cell tumor 0 trials Sub-types →
- Adult teratoma 0 trials Sub-types →
- Adult yolk sac tumor 0 trials
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Fallopian tube germ cell tumor 0 trials
2 sub-types
- Fallopian tube gestational choriocarcinoma 0 trials
- Fallopian tube teratoma 0 trials
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Germ cell benign neoplasm 0 trials
1 sub-type
- Benign teratoma 0 trials
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Germ cell tumor of the vulva 0 trials
2 sub-types
- Immature teratoma of vulva 0 trials
- Mixed germ cell tumor of vulva 0 trials
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Retroperitoneal germ cell neoplasm 0 trials
Most studied deeper sub-types
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Immunotherapy duo takes on resistant germ cell tumors
Disease control OngoingThis phase 2 trial tests two immunotherapy drugs, durvalumab and tremelimumab, in 30 adults with relapsed or refractory germ cell tumors. The goal is to see if the combination can shrink tumors or lower tumor markers. Participants must have measurable disease and have progressed …
Phase 2 • Sponsor: Memorial Sloan Kettering Cancer Center • Aim: Disease control
Last updated Sep 20, 2026 00:00 UTC
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New chemo combo aims to beat standard treatment for tough germ cell tumors
Disease control OngoingThis trial tests whether a new combination of chemotherapy drugs (paclitaxel, ifosfamide, and cisplatin, or TIP) works better than the current standard treatment (bleomycin, etoposide, and cisplatin, or BEP) for people with intermediate- or poor-risk germ cell tumors. These are c…
Phase 2 • Sponsor: Memorial Sloan Kettering Cancer Center • Aim: Disease control
Last updated Aug 08, 2026 00:03 UTC
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Can a targeted pill slow brain tumor growth after surgery?
Disease control ApprovedThis expanded access program offers vorasidenib, an oral drug, to people aged 12 and older with IDH-mutated glioma who have had surgery. The drug targets specific genetic mutations in tumor cells. The goal is to see if it can help control the disease without immediate need for ra…
Sponsor: Servier • Aim: Disease control
Last updated Jul 26, 2026 00:00 UTC
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Rare cancer hope: immune drug shows promise in phase 2 trial
Disease control OngoingThis study tested a drug called pembrolizumab in 157 people with rare cancers that had spread or couldn't be removed. The drug works by helping the body's immune system attack the cancer. The main goal was to see how many patients were alive and their cancer hadn't grown after 27…
Phase 2 • Sponsor: M.D. Anderson Cancer Center • Aim: Disease control
Last updated Jul 19, 2026 00:00 UTC
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Proton beam may spare healthy brain tissue in young tumor patients
Disease control OngoingThis study is testing whether proton beam radiation can effectively treat germ cell tumors in the brain while causing fewer side effects than standard photon radiation. About 45 participants aged 3 to 25 will receive daily proton radiation for 4 to 8 weeks. Researchers will track…
Sponsor: Massachusetts General Hospital • Aim: Disease control
Last updated Jun 27, 2026 14:00 UTC
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High-Dose chemo with stem cell transplant tested against standard therapy for tough germ cell cancers
Disease control OngoingThis phase 3 trial compares two chemotherapy approaches for people with germ cell tumors that have returned or not responded to initial treatment. One group receives standard-dose chemotherapy with paclitaxel, ifosfamide, and cisplatin (TIP). The other receives high-dose chemothe…
Phase 3 • Sponsor: Alliance for Clinical Trials in Oncology • Aim: Disease control
Last updated Jun 27, 2026 14:00 UTC
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Engineered immune cells take aim at childhood cancers in early trial
Disease control OngoingThis early-phase study tests a personalized cell therapy for children and young adults (up to age 26) with solid tumors that have come back or not responded to standard treatment. The therapy uses the patient's own immune cells, modified to recognize and attack a protein called B…
Phase 1 • Sponsor: Seattle Children's Hospital • Aim: Disease control
Last updated Jun 27, 2026 12:25 UTC
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Can freezing ovarian tissue help girls have babies later?
Disease control OngoingThis study offers girls from birth to age 17 the chance to freeze their ovarian tissue before medical treatments that could harm their fertility, such as chemotherapy or radiation. The tissue is removed surgically and stored. Later, if they want to have children, the tissue can b…
Sponsor: Mayo Clinic • Aim: Disease control
Last updated Jun 27, 2026 12:10 UTC
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New hope for incurable germ cell tumors? cabozantinib trial underway
Disease control OngoingThis phase II trial is testing the drug cabozantinib in 50 patients with germ cell tumors that have not responded to standard chemotherapy. The goal is to see if the drug can stop or slow tumor growth. Patients take cabozantinib daily until the disease worsens or side effects bec…
Phase 2 • Sponsor: Jennifer King • Aim: Disease control
Last updated Jun 27, 2026 08:11 UTC
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Engineered immune cells injected directly into brain show promise for kids with deadly tumors
Disease control OngoingThis early-phase study tests whether specially engineered immune cells (CAR T cells) can be safely given directly into the brain or spinal fluid of children and young adults with HER2-positive brain tumors that have come back or not responded to standard treatments. The therapy a…
Phase 1 • Sponsor: Seattle Children's Hospital • Aim: Disease control
Last updated Jun 27, 2026 08:04 UTC
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Engineered immune cells take on childhood cancers in first human test
Disease control OngoingThis early-stage trial tests a new type of immunotherapy for children and young adults with solid tumors that have not responded to standard treatments. The therapy uses the patient's own immune cells (T cells) that are genetically modified to recognize and attack cancer cells ca…
Phase 1 • Sponsor: Seattle Children's Hospital • Aim: Disease control
Last updated Jun 27, 2026 07:59 UTC
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Hearing loss shield tested in kids with liver cancer
Prevention PausedThis study tests whether sodium thiosulfate can prevent hearing loss in children and young adults (ages 1 month to 39 years) who are receiving cisplatin chemotherapy for relapsed or hard-to-treat liver tumors and other embryonal cancers. Some participants also get vorinostat. The…
Early phase 1 • Sponsor: Children's Hospital Medical Center, Cincinnati • Aim: Prevention
Last updated Jun 27, 2026 07:55 UTC
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New radiation technique aims to protect kids' bones and blood
Symptom relief OngoingThis study tests a special proton radiation method for children with brain tumors that need radiation to the brain and spine. The new approach spares parts of the backbone to reduce side effects like low blood counts and slowed bone growth. About 20 children aged 3 to 18 will rec…
Sponsor: Massachusetts General Hospital • Aim: Symptom relief
Last updated Aug 09, 2026 00:00 UTC
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Blood marker may predict cancer return in testicular tumor patients
Knowledge-focused OngoingThis study is testing whether a blood marker called miRNA 371 can predict if germ cell tumors (a type of cancer) will return after treatment. Researchers will collect blood samples from 956 newly diagnosed patients and track who has a relapse. The goal is to see if this marker ca…
Sponsor: SWOG Cancer Research Network • Aim: Knowledge-focused
Last updated Jun 27, 2026 11:01 UTC
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Chemo's hidden heart risk: study probes Cisplatin's effect on blood vessels
Knowledge-focused OngoingThis pilot study looks at how the chemotherapy drug cisplatin affects the inner lining of blood vessels (the endothelium) in men with germ cell tumors. Researchers will measure blood vessel function in patients receiving cisplatin and compare them to a group who had surgery only.…
Sponsor: Memorial Sloan Kettering Cancer Center • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:56 UTC
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Hidden gene changes could reveal who gets cancer
Knowledge-focused OngoingThis study searches for new gene changes (mutations) that appear in cancer patients but not in their healthy parents. By comparing DNA from 1,275 people with certain cancers and their families, researchers hope to find genetic clues that increase cancer risk. The goal is to bette…
Sponsor: Memorial Sloan Kettering Cancer Center • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:56 UTC
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Surviving rare ovarian cancer: what comes next? new study investigates Long-Term fatigue and health
Knowledge-focused OngoingThis study looks at women who have recovered from rare ovarian cancers (germ cell or sex cord-stromal tumors) to understand how the disease and chemotherapy affect their lives years later. Researchers will use questionnaires to measure chronic fatigue, quality of life, and other …
Sponsor: Centre Francois Baclesse • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:51 UTC