Esophageal varices with bleeding

This study compares two drugs, terlipressin and somatostatin, in 64 adults with liver cirrhosis who have acute gastrointestinal bleeding and acute kidney injury. Both drugs are given intravenously for up to 5 days. The main goal is to see which drug better reverses kidney injury.…

This trial tests whether an absorbable gelatin sponge works as well as cyanoacrylate glue for closing off enlarged stomach veins that can bleed. Both treatments are delivered via endoscopy with small coils. Participants are adults with a history of bleeding from these veins, and …

This trial tests whether applying sucralfate—a medication that forms a protective barrier over wounds—directly onto esophageal ulcers after variceal banding can speed healing and reduce rebleeding. The study includes adults with cirrhosis who have bleeding esophageal varices. Par…

This study tests a new procedure for people with a completely blocked main portal vein who have had at least two episodes of dangerous variceal bleeding. Doctors will use ultrasound to guide a needle into a vein in the gut, then try to reopen the blocked vein or create a new bypa…

This study tests whether the blood thinner rivaroxaban can safely improve outcomes in people with liver cirrhosis who have both a blood clot in the portal vein and a high risk of variceal bleeding. About 175 participants will receive rivaroxaban or standard care starting 48 hours…

This study compares a new procedure using a special stent (underdilated VCX-TIPS) with standard treatment (endoscopic banding plus beta-blockers) to prevent variceal rebleeding in people with cirrhosis. The new approach uses a smaller balloon to expand the stent, aiming to lower …

This study looks at two treatments—endoscopy and a procedure called TIPS—to prevent repeat bleeding from enlarged veins in the stomach or esophagus caused by liver disease. Over 1,000 adults with this condition will be followed for a year to see which approach works better. The g…

This study tests a fiber-optic navigation system that gives doctors a 3D view during a procedure called TIPS, which treats complications of liver cirrhosis like fluid buildup or bleeding. About 30 patients will be enrolled to see if the device reduces the number of needle sticks,…

This phase 3 trial tests whether adding albumin to standard treatment reduces re-bleeding and death in adults with cirrhosis who have acute variceal bleeding. Sixty participants will be randomly assigned to receive either albumin for three days plus standard care, or standard car…

This study tests a new procedure using an endoscopic ultrasound to guide the injection of tiny particles into the spleen, reducing blood flow and lowering the risk of dangerous bleeding in people with liver cirrhosis. The goal is to see if this method is safer and more effective …

This study looks at whether a simple, non-invasive ultrasound can predict the risk of dangerous bleeding from enlarged veins in the esophagus (varices) in people with liver cirrhosis. Researchers will measure spleen size and a key blood vessel diameter on ultrasound and compare t…