End stage renal failure

This phase 2 study tests whether a drug called TCD601 (siplizumab), combined with donor bone marrow cells and mild chemotherapy, can train the immune system to accept a new kidney without needing lifelong anti-rejection drugs. The trial involves 18 adults receiving a kidney from …

This study tested a liquid medicine called paricalcitol in children aged 0 to 9 years with severe kidney failure who are on dialysis. The goal was to see if it safely lowers high parathyroid hormone levels, a common complication. The trial was stopped early after enrolling only 2…

This pilot study tested two diuretics (furosemide and chlorthalidone) in people on dialysis who still had some kidney function. The goal was to see if these water pills could help preserve remaining kidney function, increase urine output, and reduce weight gain between dialysis s…

This trial tested a smartphone app (SKI App) that uses blockchain and AI to help dialysis patients track their health data and get personalized care tips. The goal was to see if the app could reduce emergency room visits and hospital stays compared to a basic health app. The stud…

This phase 2 study tested a weekly extended-release capsule of calcifediol (CTAP101) in 44 adults with chronic kidney disease on hemodialysis who also had vitamin D insufficiency and secondary hyperparathyroidism. The goal was to see if the drug could raise vitamin D levels and l…

This study looked at whether a blood test called ImmuKnow can help doctors better manage anti-rejection drugs in kidney transplant patients. The goal was to reduce infections while still preventing organ rejection. Only 4 patients were enrolled before the study was stopped early,…

This study tested a drug called siplizumab combined with donor bone marrow cells to help kidney transplant patients potentially stop taking anti-rejection drugs long-term. Only 4 people took part before the study was ended early. The goal was to find the best dose to safely allow…

This study tested two drugs, daratumumab and belatacept, in 5 highly sensitized dialysis patients waiting for a kidney transplant. The goal was to safely reduce the antibodies that make it very hard to find a compatible donor kidney. The trial was stopped early, but it aimed to h…

This study tested whether the drug heme arginate can help transplanted kidneys work right away, instead of being slow to start. It included 47 adults receiving a kidney from a deceased donor. Participants got either the drug or a salt water solution at transplant and 24 hours lat…

This study investigates why people with advanced chronic kidney disease (stages 3b to 5) often feel tired and weak. Researchers measure handgrip strength and muscle electrical signals in patients aged 60 and older, comparing them to healthy individuals of the same age and sex. Th…

This study looked at how the drug tacrolimus, often used after kidney transplants, affects blood sugar and insulin in people with kidney failure who are waiting for a transplant. Researchers wanted to find early signs of diabetes risk so doctors could adjust treatment. The study …

This study compared survival in people with end-stage kidney disease who were randomly assigned to either peritoneal dialysis or hemodialysis. The goal was to see which type of dialysis leads to longer life and fewer complications. The study was conducted in China and was termina…

This study aimed to see if teaching chronic kidney disease patients about their condition in a pharmacy could help them choose a dialysis type or consider a transplant. It was designed for adults in Arkansas who were not yet on dialysis. The study was stopped early after only one…

This pilot study aimed to compare two standard surgical methods for creating an arteriovenous (AV) fistula in the arm for dialysis patients with kidney failure. The goal was to see if a single procedure or two separate procedures leads to better outcomes and quality of life. Howe…