Digestive system neoplasm
MONDO:0021223A neoplasm (disease) that involves the digestive system.
Also known as: GI neoplasm, GI system neoplasm, GI system tumor, GI system tumour, GI tumor, GI tumour, digestive neoplasm, digestive system neoplasm (disease)
8712 clinical trials for this condition and its sub-types, 262 tagged with Digestive system neoplasm itself.
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Sub-types of Digestive system neoplasm
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Digestive system cancer 267 trials · 7,080 incl. sub-types
15 sub-types
- Digestive system carcinoma 25 trials · 4,898 incl. sub-types Sub-types →
- Intestinal cancer 25 trials · 2,791 incl. sub-types Sub-types →
- Liver cancer 255 trials · 1,708 incl. sub-types Sub-types →
- Malignant pancreatic neoplasm 903 trials · 1,450 incl. sub-types Sub-types →
- Gastric cancer 724 trials · 1,035 incl. sub-types Sub-types →
- Esophageal cancer 408 trials · 791 incl. sub-types Sub-types →
- Pharynx cancer 10 trials · 497 incl. sub-types Sub-types →
- Oral cavity cancer 42 trials · 290 incl. sub-types Sub-types →
- Gastroesophageal cancer 157 trials
- Gallbladder cancer 75 trials · 109 incl. sub-types Sub-types →
- Gastrointestinal lymphoma 0 trials · 7 incl. sub-types Sub-types →
- Jaw cancer 1 trial · 5 incl. sub-types Sub-types →
- Digestive system melanoma 0 trials · 2 incl. sub-types Sub-types →
- Malignant tumor of floor of mouth 0 trials · 2 incl. sub-types Sub-types →
- Spleen cancer 0 trials · 2 incl. sub-types Sub-types →
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Intestinal neoplasm 4 trials · 3,080 incl. sub-types
6 sub-types
- Colorectal neoplasm 1,495 trials · 2,900 incl. sub-types Sub-types →
- Intestinal cancer 25 trials · 2,791 incl. sub-types Sub-types →
- Small intestine neoplasm 1 trial · 223 incl. sub-types Sub-types →
- Epithelial tumor of anal canal 0 trials · 34 incl. sub-types Sub-types →
- Intestinal neuroendocrine neoplasm 7 trials · 21 incl. sub-types Sub-types →
- Intestinal benign neoplasm 1 trial · 7 incl. sub-types Sub-types →
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Hepatobiliary neoplasm 26 trials · 1,781 incl. sub-types
2 sub-types
- Liver and intrahepatic bile duct neoplasm 78 trials · 1,752 incl. sub-types Sub-types →
- Gallbladder neoplasm 63 trials · 120 incl. sub-types Sub-types →
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Pancreatic neoplasm 929 trials · 1,579 incl. sub-types
7 sub-types
- Malignant pancreatic neoplasm 903 trials · 1,450 incl. sub-types Sub-types →
- Pancreatic exocrine neoplasm 1 trial · 1,072 incl. sub-types Sub-types →
- Pancreatic neuroendocrine neoplasm 9 trials · 85 incl. sub-types Sub-types →
- Benign neoplasm of pancreas 7 trials Sub-types →
- Adenoma of pancreas 1 trial
- GCGR-related hyperglucagonemia 0 trials
- Intraductal tubulopapillary neoplasm of pancreas 0 trials
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Gastric neoplasm 686 trials · 1,102 incl. sub-types
6 sub-types
- Gastric cancer 724 trials · 1,035 incl. sub-types Sub-types →
- Gastric neuroendocrine neoplasm 3 trials · 6 incl. sub-types Sub-types →
- Gastric adenoma 3 trials Sub-types →
- Benign neoplasm of stomach 1 trial · 2 incl. sub-types Sub-types →
- Gastric hamartomatous polyp 0 trials Sub-types →
- Gastric teratoma 0 trials Sub-types →
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Neoplasm of esophagus 34 trials · 800 incl. sub-types
5 sub-types
- Esophageal cancer 408 trials · 791 incl. sub-types Sub-types →
- Benign neoplasm of esophagus 3 trials Sub-types →
- Esophageal neuroendocrine tumor 1 trial · 3 incl. sub-types Sub-types →
- Esophageal granular cell tumor 0 trials
- Neurofibroma of the esophagus 0 trials
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Pharynx neoplasm 1 trial · 506 incl. sub-types
7 sub-types
- Pharynx cancer 10 trials · 497 incl. sub-types Sub-types →
- Carcinoma of pharynx 3 trials · 457 incl. sub-types Sub-types →
- Neoplasm of oropharynx 3 trials · 280 incl. sub-types Sub-types →
- Nasopharyngeal neoplasm 37 trials · 226 incl. sub-types Sub-types →
- Neoplasm of hypopharynx 0 trials · 100 incl. sub-types Sub-types →
- Tonsil neoplasm 0 trials · 8 incl. sub-types Sub-types →
- Benign neoplasm of pharynx 0 trials Sub-types →
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Oral cavity neoplasm 13 trials · 298 incl. sub-types
3 sub-types
- Oral cavity cancer 42 trials · 290 incl. sub-types Sub-types →
- Palatal neoplasm 0 trials · 2 incl. sub-types Sub-types →
- Benign neoplasm of oral cavity 1 trial Sub-types →
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Digestive system neuroendocrine neoplasm 52 trials · 167 incl. sub-types
7 sub-types
- Digestive system neuroendocrine tumor, grade 1/2 66 trials · 145 incl. sub-types Sub-types →
- Pancreatic neuroendocrine neoplasm 9 trials · 85 incl. sub-types Sub-types →
- Intestinal neuroendocrine neoplasm 7 trials · 21 incl. sub-types Sub-types →
- Gastric neuroendocrine neoplasm 3 trials · 6 incl. sub-types Sub-types →
- Liver neuroendocrine carcinoma 3 trials Sub-types →
- Gallbladder neuroendocrine neoplasm 0 trials Sub-types →
- Salivary gland small cell carcinoma 0 trials
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Digestive system adenoma 0 trials · 127 incl. sub-types
6 sub-types
- Colorectal adenoma 96 trials · 120 incl. sub-types Sub-types →
- Adenoma of small intestine 1 trial · 4 incl. sub-types Sub-types →
- Gastric adenoma 3 trials Sub-types →
- Warthin tumor 1 trial
- Bile duct adenoma 0 trials Sub-types →
- Gallbladder adenoma 0 trials
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Tumor of salivary gland 9 trials · 85 incl. sub-types
4 sub-types
- Salivary gland cancer 62 trials · 81 incl. sub-types Sub-types →
- Neoplasm of major salivary gland 0 trials · 17 incl. sub-types Sub-types →
- Benign neoplasm of salivary gland 1 trial · 5 incl. sub-types Sub-types →
- Neoplasm of minor salivary gland 0 trials Sub-types →
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Benign digestive system neoplasm 0 trials · 41 incl. sub-types
10 sub-types
- Pleomorphic adenoma 12 trials
- Hepatobiliary benign neoplasm 2 trials · 8 incl. sub-types Sub-types →
- Benign neoplasm of pancreas 7 trials Sub-types →
- Intestinal benign neoplasm 1 trial · 7 incl. sub-types Sub-types →
- Benign neoplasm of esophagus 3 trials Sub-types →
- Benign neoplasm of stomach 1 trial · 2 incl. sub-types Sub-types →
- Hepatocellular adenoma 2 trials Sub-types →
- Benign neoplasm of gallbladder 0 trials Sub-types →
- Benign neoplasm of oropharynx 0 trials
- Bile duct papillary neoplasm 0 trials Sub-types →
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Tongue neoplasm 2 trials · 35 incl. sub-types
2 sub-types
- Tongue cancer 26 trials · 35 incl. sub-types Sub-types →
- Benign neoplasm of tongue 0 trials
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Lip neoplasm 1 trial · 15 incl. sub-types
2 sub-types
- Lip cancer 12 trials · 15 incl. sub-types Sub-types →
- Benign neoplasm of lip 0 trials
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Benign epithelial tumor of salivary glands 0 trials · 12 incl. sub-types
1 sub-type
- Pleomorphic adenoma 12 trials
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Neoplasm of jaw 1 trial · 9 incl. sub-types
5 sub-types
- Maxillary neoplasm 4 trials · 6 incl. sub-types Sub-types →
- Jaw cancer 1 trial · 5 incl. sub-types Sub-types →
- Benign neoplasm of lower jaw bone 1 trial Sub-types →
- Neoplasm of retromolar area 0 trials · 1 incl. sub-types Sub-types →
- Congenital epulis 0 trials
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Odontogenic neoplasm 0 trials · 5 incl. sub-types
4 sub-types
- Keratocystic odontogenic tumor 3 trials
- Ameloblastoma 2 trials Sub-types →
- Ameloblastic carcinoma 0 trials
- Calcifying epithelial odontogenic tumor 0 trials
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Malignant epithelial tumor of salivary glands 0 trials · 4 incl. sub-types
1 sub-type
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Gastrointestinal hamartoma 0 trials · 3 incl. sub-types
4 sub-types
- Juvenile polyp 3 trials Sub-types →
- Peutz-Jeghers polyp 0 trials Sub-types →
- Colorectal hamartoma 0 trials Sub-types →
- Gastric hamartomatous polyp 0 trials Sub-types →
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Buccal mucosa neoplasm 0 trials · 2 incl. sub-types
2 sub-types
- Cheek mucosa cancer 1 trial · 2 incl. sub-types Sub-types →
- Benign neoplasm of buccal mucosa 0 trials Sub-types →
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Gingival neoplasm 0 trials · 2 incl. sub-types
3 sub-types
- Gingival cancer 1 trial · 2 incl. sub-types Sub-types →
- Benign neoplasm of gum 0 trials Sub-types →
- Congenital epulis 0 trials
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Neoplasm of floor of mouth 0 trials · 2 incl. sub-types
2 sub-types
- Malignant tumor of floor of mouth 0 trials · 2 incl. sub-types Sub-types →
- Benign neoplasm of floor of mouth 0 trials
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Odontoma 0 trials
Most studied deeper sub-types
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Can a targeted pill shrink hard-to-treat bile duct cancers?
Disease control Not yet recruitingThis phase 2 trial tests whether daraxonrasib, an oral drug that targets cancers with a KRAS mutation, can shrink tumors in people with advanced biliary tract cancer that has progressed after first-line treatment. Participants take the drug once daily in 28-day cycles. The main g…
Phase 2 • Sponsor: Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins • Aim: Disease control
Last updated Aug 30, 2026 00:00 UTC
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Can a new drug shrink Hard-to-Treat digestive tumors?
Disease control Not yet recruitingThis study tests an experimental drug called BL-M08D1 in adults with advanced or metastatic digestive tract tumors and other solid tumors. The goal is to find the best dose and see how well it shrinks tumors and slows disease progression. Participants receive the drug by intraven…
Phase 1/2 • Sponsor: Sichuan Baili Pharmaceutical Co., Ltd. • Aim: Disease control
Last updated Aug 29, 2026 00:00 UTC
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Can a new infusion drug shrink Hard-to-Treat tumors?
Disease control Not yet recruitingThis early-stage trial is testing an investigational drug called BL-ARC002 in people with advanced gastrointestinal or other solid tumors that have spread. The main goals are to find a safe dose and to see if the drug shows any signs of shrinking tumors. Participants receive the …
Phase 1 • Sponsor: Sichuan Baili Pharmaceutical Co., Ltd. • Aim: Disease control
Last updated Aug 29, 2026 00:00 UTC
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Personalized cell therapy takes on GI cancers
Disease control Not yet recruitingThis study tests a new treatment for gastrointestinal cancer using a patient's own immune cells, which are engineered in a lab to target cancer. About 100 participants will receive these cells to see if they are safe and can shrink tumors. The trial is currently recruiting and co…
Phase 1/2 • Sponsor: Shenzhen Geno-Immune Medical Institute • Aim: Disease control
Last updated Aug 28, 2026 00:00 UTC
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A future without surgery for stomach and colon cancers?
Disease control Not yet recruitingThis study tests whether people with certain gastrointestinal cancers—like stomach, esophageal, or colorectal—can safely skip radical surgery after responding well to precision therapies such as immunotherapy or targeted drugs. Participants with specific molecular markers will be…
Sponsor: Peking University Cancer Hospital & Institute • Aim: Disease control
Last updated Aug 22, 2026 00:00 UTC
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Can a Patient's own immune cells be trained to fight advanced GI cancers?
Disease control Not yet recruitingThis early trial is testing an experimental cell therapy called cCTL-GL01 in people with advanced stomach, esophageal, colon, or rectal cancers that have not responded to standard treatments. The therapy uses a patient's own immune cells, which are specially trained in the lab to…
Phase 1 • Sponsor: The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School • Aim: Disease control
Last updated Jul 31, 2026 00:00 UTC
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Can a disposable device improve endoscopic tissue closure?
Disease control Not yet recruitingThis trial tests a new disposable endoscopic closing device for sealing gastrointestinal tissue and stopping bleeding. About 60 people needing tissue closure during endoscopy will be randomly assigned to receive either the new device or standard metal clips. The study compares ho…
Sponsor: Jiangsu Vedkang Medical Science and Technology Co., Ltd • Aim: Disease control
Last updated Jul 29, 2026 00:00 UTC
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Immunotherapy may let some GI cancer patients skip the knife
Disease control Not yet recruitingThis study looks at whether immunotherapy can shrink certain gastrointestinal cancers (like colorectal or stomach cancer) enough that some patients may not need major surgery. People whose tumors have specific genetic features (MSI-H/dMMR or POLE mutation) and who respond well to…
Sponsor: Peking University Cancer Hospital & Institute • Aim: Disease control
Last updated Jun 27, 2026 14:00 UTC
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Could some GI cancer patients avoid major surgery? new study explores organ preservation
Disease control Not yet recruitingThis study looks at whether people with certain genetic types of gastrointestinal cancers (stomach, colorectal, or anal) can safely avoid major surgery after immunotherapy. Instead of removing the organ, doctors will monitor closely or do smaller procedures to remove any remainin…
Sponsor: Peking University Cancer Hospital & Institute • Aim: Disease control
Last updated Jun 27, 2026 13:07 UTC
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Experimental combo targets stomach cancer fluid after other treatments fail
Disease control Not yet recruitingThis study tests a three-part treatment for people with advanced digestive tract cancers that have caused fluid buildup in the belly (malignant ascites) and haven't responded to standard therapies. The treatment combines low-dose radiation to the abdomen with two injected drugs: …
Phase 2 • Sponsor: Sun Yat-sen University • Aim: Disease control
Last updated Jun 27, 2026 07:52 UTC
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Radioactive antibody aims to light up hidden solid tumors
Diagnosis Not yet recruitingResearchers are testing a new imaging agent called 111In-TJD-31 that targets placental alkaline phosphatase (ALPP), a protein found on many solid tumor cells but rarely in healthy adult tissue. The study enrolls 8 participants: 2 healthy volunteers who give blood samples and 6 pa…
Phase 1 • Sponsor: Yong He • Aim: Diagnosis
Last updated Sep 13, 2026 00:00 UTC
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Could early palliative care reduce aggressive End-of-Life cancer treatments?
Symptom relief Not yet recruitingThis study looks at whether bringing in palliative care early during an unplanned hospital stay can reduce aggressive treatments at the end of life for people with advanced cancer. About 493 adults with metastatic digestive, gynecological, ENT, or sarcoma cancers will be randomly…
Sponsor: Centre Oscar Lambret • Aim: Symptom relief
Last updated Sep 19, 2026 00:00 UTC
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Yogurt as medicine? Butyrate-Rich formula tested for Cancer-Related constipation
Symptom relief Not yet recruitingThis phase II trial investigates whether a specially formulated yogurt rich in butyrate—a short-chain fatty acid—can relieve constipation in people with gastrointestinal cancer. Constipation is a common and distressing side effect of cancer and its treatments, and current medicat…
Phase 2 • Sponsor: Tianjin Medical University Cancer Institute and Hospital • Aim: Symptom relief
Last updated Jul 25, 2026 00:00 UTC
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Smartphone app aims to uncover food triggers for gut cancer survivors
Symptom relief Not yet recruitingThis study tests a mobile app called GutCheck for people who have survived gastrointestinal cancer. Participants track their diet, stress, and gut symptoms daily. The app analyzes the data to identify potential trigger foods. The goal is to see if the app is feasible and helpful …
Sponsor: Masonic Cancer Center, University of Minnesota • Aim: Symptom relief
Last updated Jun 27, 2026 14:01 UTC
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No opioids, less confusion? new study for seniors having gut surgery
Symptom relief Not yet recruitingThis study looks at whether using a drug combination without opioids during anesthesia can lower the chance of confusion (delirium) after surgery in people 65 and older having gastrointestinal surgery. About 174 participants will be randomly assigned to receive either opioid-free…
Phase 1 • Sponsor: Qianfoshan Hospital • Aim: Symptom relief
Last updated Jun 27, 2026 12:36 UTC
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Could zapping the spleen fix Chemo's side effect?
Symptom relief Not yet recruitingThis pilot study tests a new use of targeted radiation (SIRT) to the spleen in 18 adults with gastrointestinal cancer who have low platelets and an enlarged spleen from chemotherapy. The goal is to see if the procedure is safe and can raise platelet counts, helping patients stay …
Sponsor: Centre Georges Francois Leclerc • Aim: Symptom relief
Last updated Jun 27, 2026 12:34 UTC
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New study tests nutritional supplement to tame chemo side effects
Symptom relief Not yet recruitingThis study tests whether a special nutritional supplement (LH BLU) can reduce serious side effects in people with advanced gastrointestinal cancers who are starting chemotherapy. About 88 participants will either receive the supplement plus nutritional counseling or just counseli…
Sponsor: IRCCS San Raffaele • Aim: Symptom relief
Last updated Jun 27, 2026 12:33 UTC
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Could silkworm pupas be the key to fighting muscle loss in cancer survivors?
Symptom relief Not yet recruitingThis study tests whether silkworm pupa tablets can improve nutrition and reduce muscle loss (sarcopenia) in people who have completed cancer treatment. 480 participants will receive either the tablets or a placebo for 3 months. The main goal is to see if muscle strength and mass …
Phase 3 • Sponsor: First Affiliated Hospital of Zhejiang University • Aim: Symptom relief
Last updated Jun 27, 2026 12:24 UTC
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Can acupuncture needles Kick-Start a paralyzed stomach after cancer surgery?
Symptom relief Not yet recruitingThis study tests whether electroacupuncture (mild electrical pulses through thin needles) can help patients whose stomachs stop working properly after surgery for digestive tract tumors. Seventy-six adults who had such surgery and developed gastroparesis (stomach paralysis) will …
Sponsor: First Teaching Hospital of Tianjin University of Traditional Chinese Medicine • Aim: Symptom relief
Last updated Jun 27, 2026 12:23 UTC
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A simple leg lift could forewarn dangerous blood pressure drops in surgery
Knowledge-focused Not yet recruitingThis study tests whether a simple bedside maneuver—raising the legs—combined with ultrasound of the carotid artery can predict if a patient will experience a sudden drop in blood pressure after anesthesia is given. It involves adults undergoing elective surgery for gastrointestin…
Sponsor: Ankara City Hospital Bilkent • Aim: Knowledge-focused
Last updated Aug 22, 2026 00:00 UTC
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Can artificial intelligence think like a cancer tumor board?
Knowledge-focused Not yet recruitingThis study asks whether an artificial intelligence system can make the same care recommendations as a team of cancer experts for people with stomach, colon, or rectal cancer. About 69 participants will have their medical information reviewed independently by both the AI and a mul…
Sponsor: Shanghai Minimally Invasive Surgery Center • Aim: Knowledge-focused
Last updated Aug 07, 2026 00:00 UTC
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New program aims to make cancer surgery safer for seniors
Knowledge-focused Not yet recruitingThis study looks at how a special program, called the Geriatric Surgery Verification Program, works at the James Cancer Hospital. The program helps doctors and nurses better care for patients aged 65 and older who need cancer surgery. It includes checking for age-related issues l…
Sponsor: Ohio State University Comprehensive Cancer Center • Aim: Knowledge-focused
Last updated Jul 25, 2026 00:00 UTC
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Immunotherapy may change how your body processes other drugs
Knowledge-focused Not yet recruitingThis study will test whether immunotherapy drugs (immune checkpoint inhibitors) change how the liver processes other medications. About 80 adults with various cancers who are starting immunotherapy will take a low-dose cocktail of 7 common drugs. Researchers will measure drug lev…
Early phase 1 • Sponsor: Indiana University • Aim: Knowledge-focused
Last updated Jul 17, 2026 00:00 UTC
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Can a digital Pre-Surgery boost help cancer patients recover faster?
Knowledge-focused Not yet recruitingThis study tests whether a digitally supported prehabilitation program is feasible for patients awaiting major surgery for cancers of the pancreas, liver, stomach, or esophagus. The program includes supervised exercise, nutritional counseling, psychological support, and digital t…
Sponsor: Ludwig Boltzmann Institute for Digital Health and Prevention • Aim: Knowledge-focused
Last updated Jun 27, 2026 14:00 UTC
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Massive cancer registry aims to unlock better GI cancer care
Knowledge-focused Not yet recruitingThis study is a registry that collects medical information and biological samples from up to 100,000 people with gastrointestinal cancers, such as pancreatic or colorectal cancer. No new treatments or drugs are given. The goal is to gather real-world data to help researchers answ…
Sponsor: Canopy Cancer Collective, LLC • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:37 UTC
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New study aims to predict which cancer patients struggle most with eating
Knowledge-focused Not yet recruitingThis study looks at how cancer and its treatments change the way people experience food, including taste, mouth health, and overall eating pleasure. Researchers will ask 180 adults with different cancers to fill out a detailed questionnaire about their eating habits and feelings.…
Sponsor: Hospices Civils de Lyon • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:09 UTC
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AI could help decide when You're ready to recover after surgery
Knowledge-focused Not yet recruitingAfter gastrointestinal or cancer surgery, it's hard to know when it's safe to start rehabilitation. This study tests an AI tool that analyzes hospital data to predict which patients are ready for early rehab. The tool gives a simple yes/no answer to help doctors decide. The study…
Sponsor: Erasmus Medical Center • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:04 UTC
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Gut bacteria may hold key to better nutrition for cancer patients
Knowledge-focused Not yet recruitingThis study looks at how the bacteria in the gut and mouth relate to nutrition in 150 adults with digestive cancer starting chemotherapy. Researchers will collect stool and saliva samples, along with questionnaires and tests, before and after the first chemo cycle. The goal is to …
Sponsor: Hospices Civils de Lyon • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:01 UTC
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Simple Pre-Surgery steps could boost stoma Patients' quality of life
Knowledge-focused Not yet recruitingThis study will follow 100 people who need a stoma (an opening in the belly to pass stool) after surgery. Some will have their stoma site marked and get education before surgery, while others will not. The goal is to see if these steps improve quality of life and reduce problems …
Sponsor: Assistance Publique Hopitaux De Marseille • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:57 UTC
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Kidney trouble may skew chemo safety test – new study aims to fix that
Knowledge-focused Not yet recruitingThis study looks at whether kidney problems interfere with a common blood test used to check how well patients break down certain chemotherapy drugs (fluoropyrimidines). Researchers will measure DPD enzyme activity in about 742 people with breast or digestive cancer, kidney failu…
Sponsor: Centre Hospitalier Universitaire de Besancon • Aim: Knowledge-focused
Last updated Jun 26, 2026 18:38 UTC
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Real-world test of adebrelimab combo for tough cancers
Knowledge-focused Not yet recruitingThis study will observe 300 people with advanced lung or gastrointestinal cancers who receive adebrelimab combined with other treatments. Researchers will track side effects and how well the cancer responds. It is a real-world study, meaning it watches what happens in regular med…
Sponsor: Tianjin First Central Hospital • Aim: Knowledge-focused
Last updated Jun 26, 2026 17:13 UTC