Could silkworm pupas be the key to fighting muscle loss in cancer survivors?
NCT ID NCT07554807
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether silkworm pupa tablets can improve nutrition and reduce muscle loss (sarcopenia) in people who have completed cancer treatment. 480 participants will receive either the tablets or a placebo for 3 months. The main goal is to see if muscle strength and mass improve.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- silkworm pupa tablets
- What this could lead to
- If it works, this could offer a simple, natural supplement to help cancer survivors regain muscle strength and improve nutrition.
- What could go wrong
- This is an early-stage test of a supplement, not a proven treatment. The effect may be small or no better than placebo, and results may not apply to all cancer types.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 3
Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.
- Participants
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About 480 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Apr 2026
An estimate. Start dates often move.
- Expected to finish
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Mar 2028
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 80 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. fully understand and sign the Informed Consent Form (ICF); willing to follow and able to complete all trial procedures 2. Any gender, age at ICF signing: ≥ 18 years, ≤ 80 years 3. Confirmed diagnosis of malignancy 4. At screening/ enrollment, meet the definition of sarcopenia according to the 2019 Asian Working Group for Sarcopenia 5. Generally good condition, ECOG performance status ≤ 2 6. Agree to provide peripheral blood, stool, and urine samples for biomarker analysis during the study Exclusion Criteria: 1. Presence of gastrointestinal obstruction preventing oral intake at screening/enrollment 2. Use of immunosuppressants at screening/enrollment 3. Life expectancy ≤ 3 months 4. Presence of malabsorption syndrome or any condition affecting gastrointestinal absorption, e.g., chronic diarrhea (watery stools; daily stool frequency ≥ 5 times) 5. Patients planning pregnancy, pregnant, or breastfeeding 6. Known allergy to any component of the investigational products 7. Presence of severe primary diseases of the heart, brain, lung, liver, kidney, endocrine, blood, nervous systems or other acute/chronic diseases that could significantly affect treatment and prognosis 8. Presence of other severe physical or mental illnesses or laboratory abnormalities that may increase the risk of participating in the study, or patients deemed unsuitable for the study by the investigator
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
4 sites. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Affiliated Hangzhou First People's Hospital, School of Medicine, Westlake University
Hangzhou, Zhejiang, 310000, China
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Hangzhou Institute of Medicine Chinese Academy of Sciences
Hangzhou, China
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The First Affiliated Hospital, College of Medicine, Zhejiang University
Hangzhou, Zhejiang, 310003, China
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The Second Affiliated Hospital, College of Medicine, Zhejiang University
Hangzhou, Zhejiang, 310009, China
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Other studies related to the condition(s) this trial covers.
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