Diarrheal disease

This study follows up on African children who received an experimental Shigella vaccine in earlier studies. Researchers will take blood samples 1, 2, and 3 years after the last vaccine dose to see how long the immune protection lasts. No new vaccines are given in this study. The …

This trial tests whether a standardized nursing care pathway, guided by the Bristol Stool Form Scale, can reduce the severity of diarrhea in critically ill patients receiving tube feeding. The pathway involves regular stool assessments and step-by-step interventions such as adjus…

This study tests whether an artificial intelligence (AI) tool can help doctors spot precancerous growths in the upper part of the colon during a colonoscopy. About 1,200 people with symptoms like belly pain, constipation, or black stools will take part. The goal is to see if usin…

This study looks at whether a fast PCR test on stool samples can help doctors make better treatment decisions for children with stomach symptoms like diarrhea, vomiting, or belly pain. About 526 children visiting the emergency room will be randomly assigned to get either immediat…

Many homes in rural Central Appalachia rely on private wells and springs rather than treated utility water. Researchers are testing whether giving households a multi-stage point-of-use water filter reduces acute gastrointestinal illness and waterborne infections. The trial enroll…

This study tests a device that automatically adds chlorine to community water systems in rural Nigeria, without needing electricity or daily effort. The goal is to see if it makes drinking water cleaner and reduces diarrhea, especially in children under five. About 2,655 adults a…

This trial is testing whether a postbiotic supplement called Lactobacillus LB (Lactéol®) is safe for hospitalized children under 18 with weakened immune systems who have diarrhea. Participants receive the supplement twice daily for 14 to 28 days alongside standard rehydration and…

This early-phase study tests whether a mixture of 157 live bacteria from healthy stool, called MITI 001, is safe for people with diarrhea-predominant irritable bowel syndrome (IBS-D). The goal is to restore healthy gut function and ease symptoms. Only 13 adults with specific sign…

This study will follow 100 people with severe obesity who are starting a GLP-1 drug (like Ozempic or Wegovy) to see if it causes new anal or rectal problems within the first 3 months. Participants will have a check-up before starting the drug and again after 3 months to look for …

This study in Côte d'Ivoire tests whether giving mothers a cash reward for breastfeeding until their child is 24 months old increases breastfeeding rates and improves child and maternal health. About 1,040 mothers will either receive the cash incentive or just educational materia…