Diaphragm disorder

This trial tests whether a newer ventilation method, called flow-controlled ventilation, keeps the lungs and diaphragm in better shape than the standard pressure-controlled method during elective heart bypass surgery. About 154 adults scheduled for on-pump coronary artery bypass …

This pilot trial tests a procedure called FETO for fetuses with severe congenital diaphragmatic hernia (CDH), a condition where the diaphragm has a hole and the lungs don't develop fully. In FETO, a balloon is temporarily placed in the fetal windpipe to encourage lung growth, the…

This study looks at whether inhaled nitric oxide can help newborns with a hole in their diaphragm (congenital diaphragmatic hernia) who also have high blood pressure in their lungs. About 40 babies will receive the gas, and doctors will check if their oxygen levels improve within…

This phase III trial tests a procedure called FETO for severe congenital diaphragmatic hernia (CDH), where the diaphragm is incomplete and organs move into the chest. Doctors place a temporary balloon in the baby's windpipe before birth to help the lungs grow. The study will comp…

This study tests a new way to measure diaphragm activity using ultrasound in patients on a breathing machine (ventilator). The goal is to see if this measurement can help doctors identify when the lungs are not fully emptying and adjust ventilator pressure accordingly. The study …

This study will compare two types of nerve blocks for pain relief after shoulder surgery. One is a standard block that can sometimes weaken breathing; the other is a newer block that may avoid that side effect. 120 adults having shoulder arthroscopy will be randomly assigned to o…

This study looks at whether a special breathing exercise (threshold inspiratory muscle training) can make the diaphragm thicker and move better in people with stable COPD. Fifteen participants aged 40-59 with moderate COPD will do the training. The goal is to see if this exercise…

This study tests two types of nerve blocks for shoulder surgery to see which one is less likely to temporarily paralyze the diaphragm, the main muscle for breathing. About 70 adults having elective shoulder surgery will be randomly assigned to receive either a standard interscale…

Researchers at Radboud University Medical Center are studying whether the diaphragm, the main breathing muscle, enters a hibernation-like state in ICU patients who need a breathing machine. The study follows 112 adults on invasive mechanical ventilation for at least three days. S…

Researchers are studying whether repeated bedside ultrasound scans of the diaphragm can predict breathing failure in adults with septic shock. The study follows 120 patients in intensive care for up to 72 hours, measuring how far the diaphragm moves and how thick it is. The team …

This study looks at whether diaphragm ultrasound gives consistent results when performed by different anesthesiologists. Two doctors will each scan the diaphragm using three different methods, and their measurements will be compared to see which method is most reliable. The goal …

This study tests whether a new ultrasound-based index, called the Regional Diaphragmatic Synchrony Index (RDSI), can predict if patients on ventilators will succeed when their breathing tube is removed. Researchers will measure diaphragm movement and thickness in 110 adults durin…

This study tests a more sensitive ultrasound method called speckle tracking echocardiography (STE) to check heart function in newborns. Researchers will scan healthy babies and those with conditions like lung disease or oxygen deprivation to establish normal values and track chan…

This study compares three types of nerve blocks used for pain relief during shoulder surgery. The goal is to see which block is least likely to temporarily paralyze the diaphragm, the main muscle used for breathing. Seventy-five adults having shoulder surgery will be randomly ass…

This study compares two types of nerve blocks used during shoulder surgery to see which one causes less diaphragm paralysis (temporary trouble breathing). Sixty adults scheduled for shoulder surgery will receive either a standard interscalene block or a combination block. Researc…

This study checks if a special ultrasound technique (shear-wave elastography) can accurately measure diaphragm pressure without needles or tubes. Twelve healthy adults will perform breathing exercises while researchers compare ultrasound readings to standard pressure measurements…

This study looks at how long-term use of a BiPAP machine affects the diaphragm—the main breathing muscle—in people with advanced COPD. Researchers will use ultrasound to measure diaphragm thickness and movement over 6 weeks and 12 months in 30 patients. The goal is to learn wheth…