Diabetes mellitus

This study compares continuing oral diabetes medications (like metformin) versus switching to insulin in hospitalized adults with type 2 diabetes. About 255 participants will be randomly assigned to either stay on their usual pills or receive insulin injections. The goal is to se…

This study tests a drug called Diamyd in people aged 12 to 29 who were recently diagnosed with type 1 diabetes and have a specific genetic type (HLA DR3-DQ2). The goal is to see if Diamyd can help the body keep making its own insulin, which could improve blood sugar control and r…

This study tested an experimental drug called TOL-3021 in people with type 1 diabetes to see if it could help preserve the body's ability to produce insulin. The trial enrolled 78 participants aged 12 to 41 who had been diagnosed within the last 5 years. The study was terminated …

This early-stage study tested a new treatment called VCTX211 for people with type 1 diabetes. The goal was to see if implanting these special cells could help the body make insulin and reduce the need for insulin shots. Only 5 people took part, and the study was stopped early. Th…

This study tested a community-based program called Meals 4 Moms for pregnant women with gestational diabetes. Participants received tailored meals, education, and activity monitoring. The goal was to see if the program was practical and acceptable. Only 8 women were enrolled befo…

This small pilot study tested whether a low-carb diet (50-100 grams of carbs per day) combined with the diabetes drug dapagliflozin could improve blood sugar control in people with chronic kidney disease and prediabetes or type 2 diabetes. Four participants were split into two gr…

This study looked at whether taking probiotics alongside regular treatment could help lower blood sugar and improve lung function in people with both type 2 diabetes and chronic obstructive pulmonary disease (COPD). The trial planned to enroll 30 adults aged 50-85, but it was ter…

This early-phase trial tested whether nicotinamide riboside (a form of vitamin B3 sold as Niagen) could help repair nerve damage in people with type 2 diabetes or prediabetes. Only 10 participants were enrolled before the study was terminated. The main goal was to measure changes…

This study tests whether an artificial intelligence program called NeoRetina can accurately detect diabetic retinopathy and diabetic macular edema from simple eye photographs. Researchers will compare the AI's analysis to standard exams by eye doctors. The goal is to see if this …

This Mayo Clinic study tested a special smartwatch that uses light sensors to measure blood glucose, blood pressure, and heart signals. The goal was to see if the watch could give accurate readings compared to standard methods like finger-stick tests and blood pressure cuffs. The…

This study tested whether a five-week culturally tailored diabetes education program could help Hispanic men aged 18-64 with type 2 diabetes improve their self-management behaviors like healthy eating, physical activity, and medication use. The program was designed specifically f…

This study tested whether hospitalized adults with type 2 diabetes or prediabetes could safely do 30 minutes of resistance training each day. The goal was to see if this exercise routine is feasible and if it helps control blood sugar and prevent muscle loss during a hospital sta…

This study tested an experimental drug called GSK3858279 in 147 adults with chronic nerve pain from diabetes. The goal was to see if it could reduce pain better than a placebo. However, the trial was terminated early, so we have less information than planned.

This study investigates whether MRI can detect early signs of pancreatic damage linked to obesity and metabolic syndrome, which are risk factors for pancreatic cancer. Researchers will compare MRI images with tissue samples from patients undergoing pancreatic surgery, as well as …

This study looked at whether people with type 2 diabetes who have a chronic cough also have damage to small nerves in their skin. Researchers compared diabetic patients with and without chronic cough using nerve tests and skin biopsies. The study was terminated early with only 7 …

This study looked at why people with type 1 diabetes often fail to sense dangerously low blood sugar (hypoglycemia). Researchers tested how opioid drugs like morphine and naloxone affect the body's ability to respond to low sugar. The goal was to better understand the problem, no…

This study followed 167 adults with mental health issues like anxiety, depression, or sleep problems who visited their primary care doctor. Researchers used health conversations and a blood test to track lifestyle changes and heart disease risks over up to 20 years. The goal was …

This study looked at whether small, hard-to-see fat lumps under the skin (called subclinical lipohypertrophy) change how insulin is absorbed in people with diabetes. Researchers planned to enroll 20 adults with type 1 or type 2 diabetes who use insulin and had these hidden lumps.…

This study looked at Latino adults with diabetes who attended free education classes. Researchers collected information about their health habits, blood sugar levels, and barriers to medical care. The goal was to better understand the needs of this community, not to test a new tr…

This study is for people with cystic fibrosis and their family members. Its goal is to collect medical information and biological samples during regular clinic visits. These will be stored and used by researchers to learn more about how cystic fibrosis affects the body and how it…

This pilot study tested whether continuous glucose monitors (CGMs) could be used in the days before and after surgery to track blood sugar in people with diabetes. Researchers placed a CGM sensor on 22 patients during a preoperative visit and compared its readings to standard fin…

This pilot study tested an e-health system that uses tele-monitoring, tele-notification, and tele-coaching to help manage adults with at least two chronic conditions like heart failure, COPD, or diabetes. The goal was to see how well the system could detect health problems early.…

This study tested whether two medications, naloxone (a nasal spray) and diazoxide (an oral pill), could prevent the body from losing its ability to sense low blood sugar—a condition called hypoglycemia unawareness. Only 4 healthy volunteers were enrolled before the trial was stop…