Corneal disorder
MONDO:0000942A non-neoplastic or neoplastic disorder that affects the cornea. Representative examples include keratitis, bullous keratopathy, and squamous cell carcinoma.
Also known as: cornea disease, cornea disease or disorder, corneal disease, corneal disorder, disease of cornea, disease or disorder of cornea, disorder of cornea
463 clinical trials for this condition and its sub-types, 46 tagged with Corneal disorder itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
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Sub-types of Corneal disorder
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Keratitis 6 trials · 296 incl. sub-types
11 sub-types
- Keratoconjunctivitis 1 trial · 259 incl. sub-types Sub-types →
- Corneal infection 6 trials · 22 incl. sub-types Sub-types →
- Corneal ulcer 16 trials · 18 incl. sub-types Sub-types →
- Corneal neovascularization 4 trials Sub-types →
- Deep keratitis 0 trials · 1 incl. sub-types Sub-types →
- Autosomal dominant keratitis 0 trials
- Filamentary keratitis 0 trials
- Macular keratitis 0 trials
- Photokeratitis 0 trials
- Scleroperikeratitis 0 trials
- Superficial keratitis 0 trials Sub-types →
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Keratoconus 61 trials
11 sub-types
- Keratoconus, stable condition 2 trials
- Acute hydrops keratoconus 0 trials
- Keratoconus 1 0 trials
- Keratoconus 2 0 trials
- Keratoconus 3 0 trials
- Keratoconus 4 0 trials
- Keratoconus 5 0 trials
- Keratoconus 6 0 trials
- Keratoconus 7 0 trials
- Keratoconus 8 0 trials
- Keratoconus 9 0 trials
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Corneal dystrophy 6 trials · 60 incl. sub-types
13 sub-types
- Corneal endothelial dystrophy 5 trials · 36 incl. sub-types Sub-types →
- Posterior corneal dystrophy 0 trials · 34 incl. sub-types Sub-types →
- Stromal corneal dystrophy 2 trials · 16 incl. sub-types Sub-types →
- Superficial corneal dystrophy 0 trials · 7 incl. sub-types Sub-types →
- Epithelial-stromal TGFBI dystrophy 1 trial · 3 incl. sub-types Sub-types →
- Chandler syndrome 2 trials
- Epithelial and subepithelial corneal dystrophy 0 trials · 2 incl. sub-types Sub-types →
- Finnish type amyloidosis 0 trials
- Judge Misch wright syndrome 0 trials
- Autosomal dominant keratitis 0 trials
- Band keratopathy 0 trials
- Corneal dystrophy, punctiform and polychromatic pre-descemet 0 trials
- Macular dystrophy, fenestrated sheen type 0 trials
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Corneal edema 17 trials · 24 incl. sub-types
4 sub-types
- Bullous keratopathy 12 trials
- Secondary corneal edema 6 trials
- Contact lens corneal edema 0 trials
- Idiopathic corneal edema 0 trials
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Cornea neoplasm 0 trials · 17 incl. sub-types
3 sub-types
- Benign neoplasm of cornea 0 trials · 17 incl. sub-types Sub-types →
- Cornea cancer 0 trials Sub-types →
- Corneal intraepithelial neoplasm 0 trials
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Keratopathy 3 trials · 15 incl. sub-types
2 sub-types
- Bullous keratopathy 12 trials
- Band keratopathy 0 trials
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Corneal ectasia 11 trials
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Limbal stem cell deficiency 10 trials
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Pellucid marginal degeneration 4 trials
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Corneal degeneration 1 trial · 2 incl. sub-types
5 sub-types
- Arcus senilis 1 trial
- Band keratopathy 0 trials
- Nodular degeneration of cornea 0 trials
- Peripheral degeneration of cornea 0 trials
- Phthisical cornea 0 trials
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Cornea plana 0 trials · 2 incl. sub-types
2 sub-types
- Cornea plana 1, autosomal dominant 2 trials
- Cornea plana 2 0 trials
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Peters anomaly 1 trial
2 sub-types
- Peters anomaly-cataract syndrome 0 trials
- Von Hippel anomaly 0 trials
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Pseudopterygium 1 trial
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Arnold stickler bourne syndrome 0 trials
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Bowman's membrane folds or rupture 0 trials
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Terrien marginal degeneration 0 trials
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X-linked corneal dermoid 0 trials
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Brittle cornea syndrome 0 trials
2 sub-types
- Brittle cornea syndrome 1 0 trials
- Brittle cornea syndrome 2 0 trials
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Corneal argyrosis 0 trials
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Corneal deposit 0 trials
3 sub-types
- Anterior corneal pigmentation 0 trials
- Posterior corneal pigmentation 0 trials
- Stromal corneal pigmentation 0 trials
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Corneal staphyloma 0 trials
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Megalocornea 0 trials
1 sub-type
- Isolated congenital megalocornea 0 trials
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Sclerocornea 0 trials
2 sub-types
- Anterior segment dysgenesis 7 0 trials
- Sclerocornea, autosomal dominant 0 trials
Most studied deeper sub-types
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Sjögren's drug trial halted: what happened?
Disease control Stopped earlyThis study tested an experimental drug called HZN-1116 in 209 people with Sjögren's syndrome, an autoimmune disease causing dry eyes and mouth. The goal was to see if the drug could reduce disease activity and symptoms. The trial was terminated early, so results may not be availa…
Phase 2 • Sponsor: Amgen • Aim: Disease control
Last updated Jun 27, 2026 12:30 UTC
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Artificial cornea implant aims to restore sight in the blind
Disease control Stopped earlyThis trial tested a device called the CorNeat KPro, an artificial cornea, in 15 legally blind adults who could not get a standard cornea transplant. The goal was to see if the implant is safe and can improve vision. The study was terminated early, so full results are not availabl…
Sponsor: CorNeat Vision Ltd. • Aim: Disease control
Last updated Jun 27, 2026 12:30 UTC
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Could vitamin B2 and sunlight replace costly eye surgery?
Disease control Stopped earlyThis study tested whether taking vitamin B2 (riboflavin) and getting natural sunlight could strengthen the cornea in people with keratoconus, a condition that causes the cornea to thin and bulge. The approach aimed to be a simpler, cheaper alternative to the standard cross-linkin…
Sponsor: University of Missouri-Columbia • Aim: Disease control
Last updated Jun 27, 2026 08:03 UTC
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New eye drops aim to soothe dry eye inflammation
Symptom relief Stopped earlyThis study tested whether Thealoz Total eye drops can reduce inflammation and improve symptoms in people with chronic dry eye disease. The drops contain hyaluronic acid for lubrication, plus trehalose and NAAGA to fight inflammation. The trial planned to enroll 30 adults with mod…
Phase 4 • Sponsor: Medical University of Vienna • Aim: Symptom relief
Last updated Jun 27, 2026 12:30 UTC
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Dry eye drops duel: which one works better?
Symptom relief Stopped earlyThis study compared two different eye drops (Systane PRO and Refresh Optive Mega-3) to see which one works better for people with dry eye. Twenty adults with moderate dry eye symptoms were enrolled, but the study was stopped early. Participants filled out questionnaires about the…
Phase 4 • Sponsor: Scripps Poway Eyecare and Optometry • Aim: Symptom relief
Last updated Jun 27, 2026 12:07 UTC
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New gel aims to soothe dry eyes in glaucoma patients
Symptom relief Stopped earlyThis study looked at whether a preservative-free eye gel called IRIDIUM® could help relieve dry eye symptoms in people with glaucoma or high eye pressure who were already using multiple eye drop medications. The goal was to see if the gel improved comfort and quality of life. The…
Sponsor: Fidia Farmaceutici s.p.a. • Aim: Symptom relief
Last updated Jun 27, 2026 09:07 UTC
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Warm compress showdown: can a new device beat the old way for dry eye?
Symptom relief Stopped earlyThis study compared the TearCare system, a device that applies heat to the eyelids, to standard warm compresses and lid massage for people with dry eye disease. The goal was to see if TearCare is safe and better at improving tear stability and reducing eye discomfort. The study p…
Sponsor: Sight Sciences, Inc. • Aim: Symptom relief
Last updated Jun 27, 2026 07:52 UTC
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Eye tests may predict dry eye relief from artificial tears
Symptom relief Stopped earlyThis study aimed to see if certain eye tests could predict which people with dry eye disease would get relief from over-the-counter artificial tears. Researchers planned to enroll 66 adults with dry eye, but the study was terminated early with only 36 participants. Participants u…
Phase 4 • Sponsor: Tufts Medical Center • Aim: Symptom relief
Last updated Jun 27, 2026 07:51 UTC
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Contact lens coating replenisher tested for rare eye conditions
Symptom relief Stopped earlyThis study tested a monthly solution called Tangible Boost that is meant to restore a special coating on contact lenses. The goal was to see if it could improve comfort and vision in people with severe dry eye from Stevens-Johnson syndrome, Sjogren's syndrome, or graft-versus-hos…
Sponsor: Tangible Science • Aim: Symptom relief
Last updated Jun 26, 2026 18:06 UTC
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Sjögren's dry eye study probes corneal nerve damage
Knowledge-focused Stopped earlyThis study aimed to find out how many people with Sjögren's dry eye have reduced feeling in their cornea (the clear front part of the eye). Researchers measured corneal sensitivity, tear production, and pain in 103 adults with confirmed Sjögren's syndrome and dry eye. The study w…
Sponsor: Dompé Farmaceutici S.p.A • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:59 UTC