Dry eye drops duel: which one works better?
NCT ID NCT06975891
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study compared two different eye drops (Systane PRO and Refresh Optive Mega-3) to see which one works better for people with dry eye. Twenty adults with moderate dry eye symptoms were enrolled, but the study was stopped early. Participants filled out questionnaires about their eye comfort and symptoms.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Phase 4
Runs after approval, following long-term safety and how well the treatment works in everyday use.
- Participants
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20 people
The number who actually took part.
- Started
-
May 2025
- Finished
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Sep 2025
- Lead sponsor
-
Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 65 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Subjects who currently have moderate symptoms of dry eye as defined by a baseline OSDI score of 23-32 inclusive. * Subjects between ages of 18-65 inclusive. * Subjects who do not currently wear contact lenses. * Subjects willing to fill out a daily diary during the duration of the study. * Subjects willing to comply with the prescribed regimen and schedule of eye drops. * Subjects willing to attend all study visits. Exclusion Criteria: * Have an ophthalmologic diagnosis of: allergy, viral or bacterial conjunctivitis, anterior blepharitis, parasitic infestations in any ocular structure or its adnexa, unresolved ocular trauma, ocular surface scarring diseases, corneal or conjunctival ulcers, filamentous keratitis, neurotrophic keratitis, bulous keratopathy, neoplastic diseases on the ocular surface or adnexa, diseases with fibrovascular proliferations on the conjunctival and/or corneal surface, retinal and/or posterior diseases that require treatment or threaten the visual prognosis, or glaucoma. * Eyelid disorders that cause eyelid malposition, limit adequate eyelid closure or opening or cause epiphora. * History of herpetic keratitis or ocular surgery. * Have dry eye management that requires the implementation of any treatments (except artificial tears) of stage 2 of the recommendations in the treatment and management by stages for the dry eye disease of the TFOS DEWS I\| (Tear Film and Ocular Surface Society Dry Eye Workshop I). * Have a history of drug addiction or drug dependence currently or within the last two years before signing the ICF. * Have another medical condition, acute or chronic, that in the opinion of the investigator could increase the risk associated with participation in the study or the administration of the investigational product, or that could interfere with the interpretation of the results of the study. * Pregnant or lactating. * Current use of contact lenses. * Have participated in another clinical research study ≤30 days before screening visit. * Any use of eye drops, whether OTC or Rx, in last 14 days. * Subjects who have previously used either investigational product in the past. * Have known hypersensitivity to the components of the investigational product.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Scripps Poway Eyecare & Optometry
San Diego, California, 92131, United States
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