Combined immunodeficiency
MONDO:0015131A broad classification of inherited disorders presenting at birth that affect both the cell-mediated and humoral aspects of the immune response. Circulating numbers of B lymphocytes, T lymphocytes and NK cells are variable but where present do not function properly. Susceptibility to infection is the primary concern.
Also known as: CID, congenital combined immunodeficiency, X-linked combined immunodeficiency, combined T and B cell immunodeficiency, combined T cell and B cell immunodeficiency
57 clinical trials for this condition and its sub-types, 3 tagged with Combined immunodeficiency itself.
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Sub-types of Combined immunodeficiency
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Severe combined immunodeficiency 24 trials · 37 incl. sub-types
11 sub-types
- Familial severe combined immunodeficiency 0 trials · 22 incl. sub-types Sub-types →
- T-B- severe combined immunodeficiency 0 trials · 14 incl. sub-types Sub-types →
- T-B+ severe combined immunodeficiency 0 trials · 10 incl. sub-types Sub-types →
- T+ B+ severe combined immunodeficiency 0 trials Sub-types →
- T-cell immunodeficiency, congenital alopecia, and nail dystrophy 0 trials
- Immunodeficiency 79 0 trials
- Janus kinase-3 deficiency 0 trials
- Recombinase activating gene 1 deficiency 0 trials
- Recombinase activating gene 2 deficiency 0 trials
- Severe combined immunodeficiency due to CARMIL2 deficiency 0 trials
- Severe combined immunodeficiency due to CD70 deficiency 0 trials
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Ataxia telangiectasia 11 trials
1 sub-type
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Wiskott-Aldrich syndrome 10 trials
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2 sub-types
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Non-SCID combined immunodeficiency 0 trials · 1 incl. sub-types
7 sub-types
- TCR-alpha-beta-positive T-cell deficiency 1 trial
- HELIOS deficiency 0 trials
- ITPKB deficiency 0 trials
- MAN2B2 deficiency 0 trials
- NIK deficiency 0 trials
- Non-severe combined immunodeficiency due to COPG1 deficiency 0 trials
- Non-severe combined immunodeficiency due to polymerase delta deficiency 0 trials Sub-types →
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MHC class I deficiency 0 trials
3 sub-types
- MHC class I deficiency 1 0 trials
- MHC class I deficiency 2 0 trials
- MHC class I deficiency 3 0 trials
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Combined immunodeficiency syndrome 0 trials
2 sub-types
Most studied deeper sub-types
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Continued EryDex treatment studied in rare neurological disorder
Disease control Stopped earlyThis study offered continued treatment with EryDex to 101 people with ataxia telangiectasia (A-T) who had finished a previous trial. The main goal was to monitor safety, including side effects and serious events. The study was terminated early, and it did not aim to cure the dise…
Phase 3 • Sponsor: Quince Therapeutics S.p.A. • Aim: Disease control
Last updated Jun 27, 2026 12:29 UTC
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New stem cell method aims to protect kids with rare immune disease
Disease control Stopped earlyThis study tested a way to improve stem cell transplants for children with combined immunodeficiency (CID), a condition where the immune system doesn't work properly. The approach removed certain naive cells from the donor stem cells to try to prevent graft-versus-host disease (a…
Phase 2 • Sponsor: Assistance Publique - Hôpitaux de Paris • Aim: Disease control
Last updated Jun 27, 2026 12:02 UTC
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Experimental drug shows promise for rare genetic disorder
Disease control Stopped earlyThis Phase II trial tested a drug called N-Acetyl-L-Leucine (IB1001) in 17 people with Ataxia-Telangiectasia, a rare genetic disease that affects movement and immunity. The study aimed to see if the drug could improve symptoms and slow the disease over time. The trial was termina…
Phase 2 • Sponsor: IntraBio Inc • Aim: Disease control
Last updated Jun 27, 2026 12:00 UTC