Combined immunodeficiency due to ORAI1 deficiency

MONDO:0013007

A form of combined immunodeficiency due to Calcium release activated Ca2+ (CRAC) channel dysfunction characterized by recurrent infections, congenital myopathy, ectodermal dysplasia and anhydrosis.

Also known as: CID due to ORAI1 deficiency, immunodeficiency type 9, IMD9, immune dysfunction with T-cell inactivation due to calcium entry defect 1, immunodeficiency 9

1 clinical trial for this condition and its sub-types, 0 tagged with Combined immunodeficiency due to ORAI1 deficiency itself.

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Where it sits in the disease tree

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↑ Combined immunodeficiency due to CRAC channel dysfunction (1)

Including sub-types (1) Tagged with Combined immunodeficiency due to ORAI1 deficiency (0)

Terminated 1

New stem cell method aims to protect kids with rare immune disease

Disease control Stopped early

This study tested a way to improve stem cell transplants for children with combined immunodeficiency (CID), a condition where the immune system doesn't work properly. The approach removed certain naive cells from the donor stem cells to try to prevent graft-versus-host disease (a…

Phase 2 • Sponsor: Assistance Publique - Hôpitaux de Paris • Aim: Disease control

Last updated Jun 27, 2026 12:02 UTC

Combined immunodeficiency due to ORAI1 deficiency

Where it sits in the disease tree

New stem cell method aims to protect kids with rare immune disease