Combined immunodeficiency
MONDO:0015131A broad classification of inherited disorders presenting at birth that affect both the cell-mediated and humoral aspects of the immune response. Circulating numbers of B lymphocytes, T lymphocytes and NK cells are variable but where present do not function properly. Susceptibility to infection is the primary concern.
Also known as: CID, congenital combined immunodeficiency, X-linked combined immunodeficiency, combined T and B cell immunodeficiency, combined T cell and B cell immunodeficiency
57 clinical trials for this condition and its sub-types, 3 tagged with Combined immunodeficiency itself.
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Sub-types of Combined immunodeficiency
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Severe combined immunodeficiency 24 trials · 37 incl. sub-types
11 sub-types
- Familial severe combined immunodeficiency 0 trials · 22 incl. sub-types Sub-types →
- T-B- severe combined immunodeficiency 0 trials · 14 incl. sub-types Sub-types →
- T-B+ severe combined immunodeficiency 0 trials · 10 incl. sub-types Sub-types →
- T+ B+ severe combined immunodeficiency 0 trials Sub-types →
- T-cell immunodeficiency, congenital alopecia, and nail dystrophy 0 trials
- Immunodeficiency 79 0 trials
- Janus kinase-3 deficiency 0 trials
- Recombinase activating gene 1 deficiency 0 trials
- Recombinase activating gene 2 deficiency 0 trials
- Severe combined immunodeficiency due to CARMIL2 deficiency 0 trials
- Severe combined immunodeficiency due to CD70 deficiency 0 trials
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Ataxia telangiectasia 11 trials
1 sub-type
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Wiskott-Aldrich syndrome 10 trials
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2 sub-types
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Non-SCID combined immunodeficiency 0 trials · 1 incl. sub-types
7 sub-types
- TCR-alpha-beta-positive T-cell deficiency 1 trial
- HELIOS deficiency 0 trials
- ITPKB deficiency 0 trials
- MAN2B2 deficiency 0 trials
- NIK deficiency 0 trials
- Non-severe combined immunodeficiency due to COPG1 deficiency 0 trials
- Non-severe combined immunodeficiency due to polymerase delta deficiency 0 trials Sub-types →
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MHC class I deficiency 0 trials
3 sub-types
- MHC class I deficiency 1 0 trials
- MHC class I deficiency 2 0 trials
- MHC class I deficiency 3 0 trials
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Combined immunodeficiency syndrome 0 trials
2 sub-types
Most studied deeper sub-types
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Bubble boy disease gene therapy trial launches
Disease control Not yet recruitingThis trial tests a gene therapy given by IV for X-linked severe combined immunodeficiency (SCID-X1), a rare immune disorder. Ten participants with no matched donor will receive a lentiviral vector to correct the genetic defect. The goal is to restore immune function and improve s…
Phase 1/2 • Sponsor: Shenzhen Geno-Immune Medical Institute • Aim: Disease control
Last updated Aug 29, 2026 00:00 UTC
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One-Time gene fix could rescue 'Bubble Boy' disease
Disease control Not yet recruitingThis study tests a gene therapy given by IV for ADA-SCID, a rare and life-threatening immune disorder. The treatment uses a modified virus to deliver a working gene, aiming to restore the immune system. Ten participants will be monitored for safety and immune recovery over one ye…
Sponsor: Shenzhen Geno-Immune Medical Institute • Aim: Disease control
Last updated Aug 28, 2026 00:00 UTC
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Can umbilical cord stem cells help repair spinal cord injuries?
Disease control Not yet recruitingThis trial is testing whether a single injection of stem cells from umbilical cord tissue, given into the spinal fluid, is safe and tolerable for people who have had a traumatic spinal cord injury within the past ten years. The study will monitor participants for side effects and…
Early phase 1 • Sponsor: Cell Therapy LLC • Aim: Disease control
Last updated Aug 02, 2026 00:00 UTC
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Could a chemo drug tame a rare immune disorder?
Disease control Not yet recruitingThis study tests the drug decitabine in 6 boys with XMEN disease, a rare genetic condition that weakens the immune system and damages the liver. The goal is to see if decitabine can improve liver function and immune cell activity. It is a very early, small trial focused on safety…
Phase 4 • Sponsor: Children's Hospital of Fudan University • Aim: Disease control
Last updated Jun 27, 2026 12:25 UTC
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New therapy aims to ease grief after miscarriage or stillbirth
Symptom relief Not yet recruitingThis pilot study tests a 4-week program based on acceptance and commitment therapy (ACT) for women who have experienced a miscarriage, stillbirth, or newborn death within the past year. The program includes six sessions plus a booster, combining in-person and video meetings. Rese…
Sponsor: Second Xiangya Hospital of Central South University • Aim: Symptom relief
Last updated Jun 27, 2026 12:26 UTC
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Could early markers unlock treatments for a rare childhood disease?
Knowledge-focused Not yet recruitingThis study follows babies and young children (up to age 5) who have a genetic diagnosis of ataxia telangiectasia (A-T), a rare disease that affects movement and immunity. Researchers use brain and lung scans, blood tests, and movement analysis to spot early signs of disease progr…
Sponsor: University of Nottingham • Aim: Knowledge-focused
Last updated Jul 18, 2026 00:00 UTC
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Newborn SCID screening study aims to unlock secrets of immune disorders
Knowledge-focused Not yet recruitingThis study follows infants who had a positive newborn screening test for severe combined immunodeficiency (SCID), a group of genetic disorders that leave babies vulnerable to life-threatening infections. Researchers will track these children to identify the underlying causes of t…
Sponsor: Nantes University Hospital • Aim: Knowledge-focused
Last updated Jul 17, 2026 00:00 UTC