Combat disorder

This trial tests whether propranolol, a blood pressure drug, can reduce PTSD symptoms in women who have experienced severe violence. Participants take propranolol and then revisit their traumatic memories in a structured session with a psychologist. The study compares this approa…

This phase 2 trial is testing whether a one-day treatment combining repetitive transcranial magnetic stimulation (rTMS) with the drug D-cycloserine can help military personnel and veterans with PTSD. The study will enroll 50 participants who will receive either the active treatme…

This phase 2 trial is testing whether a single day of repetitive transcranial magnetic stimulation (rTMS), combined with a dose of D-cycloserine, can help first responders with post-traumatic stress disorder (PTSD). About 50 participants will receive either the active treatment o…

This trial explores whether personalized brain imaging can predict who responds best to three rapid-acting treatments for suicidal ideation in people with depression or PTSD. Participants receive either real-time brain feedback (neurofeedback), a form of magnetic brain stimulatio…

This study tests whether MDMA, combined with a type of talk therapy called Acceptance and Commitment Therapy (ACT), can help treat post-traumatic stress disorder (PTSD) in military service members. Participants receive either a full or low dose of MDMA during therapy sessions. Th…

This study explores whether a non-invasive device that stimulates the vagus nerve through the ear can help people with PTSD learn to dampen fear responses. Participants will receive either active or sham stimulation while their body reactions (heart rate, sweat, startle) are meas…

This pilot study tests a behavioral program called CBITS-RTM, adapted for teens in juvenile detention. The program combines group and individual therapy to address post-traumatic stress and includes a module on racial trauma. Researchers want to see if it reduces PTSD symptoms an…

This study tests whether the blood pressure medication propranolol can prevent post-traumatic stress disorder (PTSD) in women who have experienced sexual violence. 34 women will receive either propranolol or a placebo within 72 hours of the assault, then take it for about three w…

This study tests whether a single dose of psilocybin (the active ingredient in magic mushrooms) combined with talk therapy can reduce PTSD symptoms in adults who have survived intimate partner violence. 76 participants will receive either a high or low dose and complete weekly th…

This study tests an adapted version of a therapy called STAIR-NT, designed to help first responders who have both PTSD and a history of traumatic brain injury. The therapy combines skills training and narrative therapy to address emotional regulation and interpersonal issues. Res…

This study tests whether inhaling high-THC cannabis can safely reduce PTSD symptoms in 320 veterans. Participants will either receive active cannabis or a placebo with almost no THC. The goal is to see if cannabis helps with PTSD severity and daily functioning, providing real-wor…

This trial tests whether a culturally tailored mobile health program, called Self-Compassion, Health, and Empowerment (SHE), can improve mental health in Chinese immigrant women who have experienced intimate partner violence. Participants receive six weekly sessions covering safe…

This study tests whether adding a type of brain stimulation called intermittent theta-burst stimulation (iTBS) can help adults with post-traumatic stress disorder (PTSD) who do not improve enough with standard eye movement desensitization and reprocessing (EMDR) therapy alone. Pa…

This study tests whether adding the sleep medication suvorexant to a shortened form of exposure therapy helps veterans with PTSD and insomnia. Participants take suvorexant or a placebo nightly for 8 weeks while attending weekly therapy sessions. Researchers measure changes in PTS…

This study tests a two-session Zoom-based therapy designed to change beliefs about mental health treatment in Deaf adults who are not currently in care. Researchers will compare those who receive the therapy to a waitlist group to see if it increases treatment-seeking and reduces…

This study looks at two ways to inject botulinum toxin (like Botox) to treat long-term nerve pain from amputation in 100 combat veterans. The goal is to see which method—injecting inside the nerve or around it—works better for reducing pain and improving daily life. Participants …

This study tests whether a type of cognitive training called Action-Based Cognitive Remediation (ABCR) can improve thinking skills in people with various psychiatric conditions like depression, schizophrenia, anxiety, PTSD, and autism. Participants will complete computer exercise…

This study compares a new trauma-focused therapy (MBT-TF) with standard therapy for adults who have both borderline personality disorder and complex PTSD. The goal is to see if the new approach is practical and helpful for reducing symptoms. Forty participants will be followed fo…

This study tests whether EMDR group therapy can help adults who experienced the April 2025 Silivri earthquake in Turkey. Forty participants will be randomly assigned to either the therapy group or a waitlist. Researchers will measure changes in PTSD, depression, anxiety, sleep qu…

This Phase 2a trial will test whether PT150, a drug that blocks a stress-related receptor, can safely reduce PTSD symptoms in 120 US veterans. Participants will receive either PT150 or a placebo for several weeks, and researchers will track changes in PTSD severity and side effec…

This study follows 500 adults with open limb injuries from drone attacks to understand why some develop severe wound infections. Researchers will collect detailed medical data to link the extent of tissue damage with infection outcomes. The goal is to improve early identification…

This study looks at severely injured adults with multiple traumatic injuries who receive one or more nerve blocks for pain. Researchers want to see if having more blocks improves pain control, reduces opioid use, and helps patients regain mobility faster, or if it increases risks…

This study looks back at the medical records of 300 people with arrhythmogenic cardiomyopathy who have an implantable cardioverter-defibrillator (ICD) and have had dangerous heart rhythms. Researchers want to count how often ICD-related problems occur, such as lead failure or ina…

This study follows 300 Ukrainian veterans who lost a limb in combat to see if longer evacuation times or extended tourniquet use increase the risk of developing PTSD. Participants will be monitored for 18 months using PTSD symptom questionnaires. The goal is to identify factors t…

This study follows 150 adults with severe arm or leg injuries that required a tourniquet to stop bleeding. Researchers will track how long the tourniquet was used and check for pain, nerve damage, and recovery over 6 months. The goal is to see if longer tourniquet use increases t…

This study looks at how a brief writing therapy called Written Exposure Therapy (WET) works for people with both PTSD and substance use disorders who are in residential treatment. About 108 participants will either do WET or neutral writing alongside their usual care. Researchers…